Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist

ACS Medicinal Chemistry Letters

Volumn 2, Issue 12, 2011, Pages 913-918

  Xue, Chu Biao ^a   Wang, Anlai ^a   Han, Qi ^a   Zhang, Yingxin ^a   Cao, Ganfeng ^a   Feng, Hao ^a   Huang, Taisheng ^a   Zheng, Changsheng ^a   Xia, Michael ^a   Zhang, Ke ^a   Kong, Lingquan ^a   Glenn, Joseph ^a   Anand, Rajan ^a   Meloni, David ^a   Robinson, D J ^a   Shao, Lixin ^a   Storace, Lou ^a   Li, Mei ^a   Hughes, Robert O ^b   Devraj, Rajesh ^b   Morton, Philip A ^b   Rogier, D Joseph ^b   Covington, Maryanne ^a   Scherle, Peggy ^a   Diamond, Sharon ^a   Emm, Tom ^a   Yeleswaram, Swamy ^a   Contel, Nancy ^a   Vaddi, Kris ^a   Newton, Robert ^a   Hollis, Greg ^a   Metcalf, Brian ^a   more..

^a Drug Metabolism Pharmacokinetics Clinical Pharmacology   (United States)

^b PFIZER INC   (United States)

Author keywords

antagonist; CCR2; chemokine; hERG

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; INCB 8761; PF 4136309; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

EID: 83455258270     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200199c     Document Type: Article

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