γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2425-2430

  Cherney, Robert J ^a   Mo, Ruowei ^a   Meyer, Dayton T ^a   Voss, Matthew E ^a   Yang, Michael G ^a   Santella III, Joseph B ^a   Duncia, John V ^a   Lo, Yvonne C ^a   Yang, Gengjie ^a   Miller, Persymphonie B ^a   Scherle, Peggy A ^a   Zhao, Qihong ^a   Mandlekar, Sandhya ^a   Cvijic, Mary Ellen ^a   Barrish, Joel C ^a   Decicco, Carl P ^a   Carter, Percy H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

lactam; CCR2; CCR2 Antagonist; Chemokine antagonist; GPCR

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; CYCLOHEXANE DERIVATIVE; GAMMA LACTAM DERIVATIVE; GLYCINAMIDE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN CACO 2; CHEMOTAXIS; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL;

ANIMALS; CHEMOTAXIS; CYCLOHEXANES; GLYCINE; LACTAMS; MICE; RECEPTORS, CCR2;

EID: 77950042517     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.035     Document Type: Article

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