Identification of a sulfonamide series of CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 13, 2010, Pages 3961-3964

  Peace, Simon ^a   Philp, Joanne ^b   Brooks, Carl ^b   Piercy, Val ^a   Moores, Kitty ^a   Smethurst, Chris ^a   Watson, Steve ^a   Gaines, Simon ^a   Zippoli, Mara ^a   Mookherjee, Claudette ^a   Ife, Robert ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

CCR2 antagonists; pKa; Sulfonamides

Indexed keywords

CHEMOKINE RECEPTOR CCR2; PROTEIN INHIBITOR; SULFONAMIDE;

ARTICLE; DRUG IDENTIFICATION; HIGH THROUGHPUT SCREENING; LIPOPHILICITY; MOLECULAR WEIGHT; PKA; PLASMA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MOLECULAR STRUCTURE; RECEPTORS, CCR1; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77954312019     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.142     Document Type: Article

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