Protective effect of new adenosine analog B2 against serum deprivation-induced PC12 cell injury

Yaoxue Xuebao

Volumn 46, Issue 10, 2011, Pages 1199-1203

  Sun, Jing ^a   Li, Min ^a   Kang, Rui Xia ^a   Shi, Jian Gong ^a   Zhang, Jian Jun ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Adenosine A2A receptor; Adenosine analog B2; Oxidative stress; Serum deprivation

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ADENOSINE DERIVATIVE; RADIOLIGAND; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL STRAIN; CELL SURVIVAL; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORPUS STRIATUM; NONHUMAN; OXIDATIVE STRESS; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CELL SURVIVAL; CORPUS STRIATUM; CULTURE MEDIA, SERUM-FREE; FEMALE; MALE; PC12 CELLS; PYRIMIDINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR, ADENOSINE A2A; TRIAZOLES;

EID: 83455258036     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Batistatou A, Greene LA. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity [J]. Cell Biol, 1991, 115: 461-471. (Pubitemid 21926040)
2. Ribeiro JA, Sebastiao AM, de Mendonca A. Adenosine receptors in the nervous system: pathophysiological implications [J]. Prog Neurobiol, 2002, 68: 377-392. (Pubitemid 36165128)
3. 2A receptors regulate oxidative stress formation in rat pheochromocytoma PC12 cells during serum deprivation [J]. Neurosci Lett, 2003, 350: 127-131.
4. Ohnuma K, Hayashi Y, Furue M, et al. Serum-free culture conditions for serial subculture of undifferentiated PC12 cells [J]. J Neurosci Methods, 2006, 151: 250-261.
5. Macdonald NJ, Perez-Polo JR, Bennett AD, et al. NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa [J]. Neurosci Res, 1999, 57: 219-226. (Pubitemid 29300324)
6. Dermitzaki E, Chatzaki E, Gravanis A, et al. Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal [J]. Neurochemistry, 2000, 74: 960-969. (Pubitemid 30104291)
7. Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets [J]. Nat Rev Drug Discov, 2006, 5: 247-264. (Pubitemid 43336037)
8. 2A receptors in Jurkat cells and PC12 cells using adenosine receptor agonists [J]. Naunyn Schmiedebergs Arch Pharmacol, 1996, 353: 250-260.
9. Huang NK, Lin YW, Huang CL, et al. Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells [J]. J Biol Chem, 2001, 276: 13838-13846.
10. Wadia JS, Chalmers-Redman RM, Ju WJ, et al. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl [J]. J Neurosci, 1998, 18: 932-947. (Pubitemid 28112916)