Multifunctional mesoporous silica nanospheres with cleavable Gd(III) chelates as MRI contrast agents: Synthesis, characterization, target-specificity, and renal clearance

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Volumn 7, Issue 24, 2011, Pages 3519-3528

  Lin, Wenbin ^a   Vivero Escoto, Juan L ^a   Taylor Pashow, Kathryn M L ^b   Huxford, Rachel C ^a   Della Rocca, Joseph ^a   Okoruwa, Christie ^a   An, Hongyu ^c   Lin, Weili ^c  

^a University of North Carolina at Chapel Hill   (United States)

^b SAVANNAH RIVER NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

biodegradable; contrast agents; magnetic resonance imaging; silica nanospheres; target specific nanoparticles

Indexed keywords

BIODEGRADABLE; BLOOD POOL; CONTRAST AGENT; FUNCTIONALIZED; HUMAN COLON; IMAGING CONTRAST; IN-VITRO; IN-VIVO; MAGNETIC RESONANCE IMAGING CONTRAST AGENTS; MESOPOROUS SILICA; MRI CONTRAST AGENTS; PANCREATIC CANCERS; RELEASE KINETICS; RENAL CLEARANCE; RENAL EXCRETION; SILICA NANOSPHERES;

BIOCOMPATIBILITY; CHELATION; GADOLINIUM; GLYCOLS; NANOSPHERES; POLYETHYLENE GLYCOLS; SILICA;

MAGNETIC RESONANCE IMAGING;

BENZAMIDE DERIVATIVE; CHELATING AGENT; CONTRAST MEDIUM; GADOLINIUM; MACROGOL DERIVATIVE; NANOSPHERE; SILICON DIOXIDE;

ANIMAL; ARTICLE; CELL STRAIN HT29; CHEMISTRY; CONFOCAL MICROSCOPY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; METABOLISM; METHODOLOGY; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; OXIDATION REDUCTION REACTION; POROSITY; SYNTHESIS; ULTRASTRUCTURE;

ANIMALS; BENZAMIDES; CHELATING AGENTS; CONTRAST MEDIA; FEMALE; GADOLINIUM; HT29 CELLS; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; NANOSPHERES; OXIDATION-REDUCTION; POLYETHYLENE GLYCOLS; POROSITY; SILICON DIOXIDE;

EID: 83455247330     PISSN: 16136810     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.201100521     Document Type: Article

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