Effect of size and charge on pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide Gd(III) complexes

Journal of Controlled Release

Volumn 112, Issue 3, 2006, Pages 350-356

  Zong, Yuda ^a   Guo, Junyu ^b   Ke, Tianyi ^a   Mohs, Aaron M ^a   Parker, Dennis L ^b   Lu, Zheng Rong ^a  

^a University of UT   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Biodegradable macromolecular contrast agents; Blood pool contrast agents; Gadolinium; MRI; Polydisulfide

Indexed keywords

BIODEGRADATION; BLOOD; COMPLEXATION; COPOLYMERS; GADOLINIUM; MAGNETIC RESONANCE IMAGING;

BIODEGRADABLE MACROMOLECULAR CONTRAST AGENTS; BLOOD POOL CONTRAST AGENTS; IN VIVO CONTRAST ENHANCEMENT; POLYDISULFIDE;

PHARMACOKINETICS;

GADOLINIUM; GADOLINIUM CYSTINE COPOLYMER; GADOLINIUM CYSTINE DIETHYL ESTER COPOLYMER; GADOLINIUM PENTETATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG LIVER LEVEL; DRUG STRUCTURE; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

ANIMALS; CONTRAST MEDIA; DISULFIDES; ELECTROSTATICS; FEMALE; GADOLINIUM; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33646689144     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.03.006     Document Type: Article

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