Current computer modeling cannot explain why two highly similar sequences fold into different structures

Biochemistry

Volumn 50, Issue 50, 2011, Pages 10965-10973

  Allison, Jane R ^a   Bergeler, Maike ^a   Hansen, Niels ^a   Van Gunsteren, Wilfred F ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER MODELING; DIFFERENT STRUCTURE; FORCE FIELDS; FREE-ENERGY DIFFERENCE; MOLECULAR DYNAMICS SIMULATIONS; NATIVE STRUCTURES; PROTEIN STRUCTURES; SINGLE STRUCTURE; STABILITY RESULTS; STABLE STRUCTURES; STRUCTURE ANALYSIS;

AMINO ACIDS; COMPUTER SIMULATION; FREE ENERGY; MODEL STRUCTURES; MOLECULAR DYNAMICS;

PROTEINS;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER MODEL; ENERGY YIELD; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DATABASES, PROTEIN; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERUM ALBUMIN; THERMODYNAMICS;

EID: 83455221631     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2015663     Document Type: Article

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