Commentary: Liver enzymes and the risk of adverse cardiovascular outcomes-the lower, the better?

International Journal of Epidemiology

Volumn 40, Issue 6, 2011, Pages 1539-1541

  Marchesini, Giulio ^a   Targher, Giovanni ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; LIVER ENZYME;

ADVERSE OUTCOME; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHRONIC LIVER DISEASE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEALTH SURVEY; HEPATITIS C; ISCHEMIC HEART DISEASE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NOTE; PRIORITY JOURNAL; STROKE; VASCULAR DISEASE;

ALANINE TRANSAMINASE; CARDIOVASCULAR DISEASES; FEMALE; HUMANS; MALE;

EID: 83455213413     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyr187     Document Type: Note

References (20)

1. Marchesini G, Bugianesi E, Forlani G et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23.
2. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010;363:1341-50.
3. Ekstedt M, Franzen LE, Mathiesen UL et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865-73.
4. Pratt DS, Kaplan MM. Evaluation of abnormal liverenzyme results in asymptomatic patients. N Engl J Med 2000;342:1266-71.
5. Fraser A, Harris R, Sattar N, Ebrahim S, Davey Smith G, Lawlor DA. Alanine aminotransferase, gammaglutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. Diabetes Care 2009;32:741-50.
6. Fraser A, Harris R, Sattar N, Ebrahim S, Davey Smith G, Lawlor DA. Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis. Arterioscler Thromb Vasc Biol 2007;27:2729-35.
7. Lee DH, Buijsse B, Steffen L, Holtzman J, Luepker R, Jacobs DR Jr. Association between serum gammaglutamyltransferase and cardiovascular mortality varies by age: the Minnesota Heart Survey. Eur J Cardiovasc Prev Rehabil 2009;16:16-20.
8. Bedogni G, Bellentani S, Miglioli L et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006;6:33.
9. Liangpunsakul S, Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 2005;329:111-16.
10. Ioannou GN, Weiss NS, Boyko EJ, Mozaffarian D, Lee SP. Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States. Hepatology 2006;43:1145-51.
11. Ford I, Mooijart SP, Lloyd S et al. The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovasciular and non-cardiovascuilar outcomes. Int J Epidemiol 2011;40:1530-38.
12. Prati D, Taioli E, Zanella A et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002;137:1-10.
13. Lippi G, Franchini M, Favaloro EJ, Targher G. Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox". Semin Thromb Hemost 2010;36:59-70.
14. Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 2007;298:2028-37.
15. Le Couteur DG, Blyth FM, Creasey HM et al. The association of alanine transaminase with aging, frailty, and mortality. J Gerontol A Biol Sci Med Sci 2010;65:712-17.
16. Elinav E, Ben-Dov IZ, Ackerman E et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 2005;100: 2201-04.
17. Hall KE, Proctor DD, Fisher L, Rose S. American Gastroenterological Association Future Trends Committee report: effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology 2005;129:1305-38.
18. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003;124: 71-79.
19. Dong MH, Bettencourt R, Barrett-Connor E, Loomba R. Alanine aminotransferase decreases with age: the Rancho Bernardo Study. PLoS One 2010;5:e14254.
20. Wakabayashi H, Nishiyama Y, Ushiyama T, Maeba T, Maeta H. Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: comparison with CT volumetry. J Surg Res 2002;106: 246-53.