Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course

Neuropathology

Volumn 32, Issue 1, 2012, Pages 69-76

  Masui, Kenta ^a   Nakata, Yukako ^b   Fujii, Naoki ^b   Iwaki, Toru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Omuta National Hospital   (Japan)

Author keywords

synuclein; Glial cytoplasmic inclusion; Multiple system atrophy; Prolonged clinical course; Ubiquitin

Indexed keywords

ALPHA SYNUCLEIN; PROTEIN P62; UBIQUITIN;

ADULT; ARTICLE; AUTOPSY; BRAIN REGION; CASE REPORT; CELL INCLUSION; CLINICAL FEATURE; DISEASE COURSE; FEMALE; GLIA CELL; HUMAN; IMAGING; NERVE DEGENERATION; PRIORITY JOURNAL; SHY DRAGER SYNDROME; TRACHEOSTOMY;

AGE OF ONSET; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; BRAIN; FEMALE; HUMANS; INCLUSION BODIES; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; NERVE DEGENERATION; NEUROGLIA; UBIQUITIN;

EID: 83455210612     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2011.01222.x     Document Type: Article

References (29)

1. Gilman S, Wenning GK, Low PA etal. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 2008; 71: 670-676.
2. Lantos PL, Quinn N. Multiple system atrophy. In: Dickson DW, ed. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. Basel: ISN Neuropath Press, 2003; 203-214.
3. Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989; 94: 79-100.
4. Nakazato Y, Yamazaki H, Hirato J, Ishida Y, Yamaguchi H. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol 1990; 49: 521-530.
5. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H. Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998; 249: 180-182.
6. Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ. Alpha synuclein in neurodegenerative disorders: murderer or accomplice? Nat Med 1998; 4: 755-757.
7. Gai WP, Power JH, Blumbergs PC, Blessing WW. Multiple-system atrophy: a new alpha-synuclein disease? Lancet 1998; 352: 547-548.
8. Wenning GK, Stefanova N. Recent developments in multiple system atrophy. J Neurol 2009; 256: 1791-1808.
9. Stefanova N, Bücke P, Duerr S, Wenning GK. Multiple system atrophy: an update. Lancet Neurol 2009; 8: 1172-1178.
10. Ben-Shlomo Y, Wenning GK, Tison F, Quinn NP. Survival of patients with pathologically proven multiple system atrophy: a meta-analysis. Neurology 1997; 48: 384-393.
11. Watanabe H, Saito Y, Terao S etal. Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain 2002; 125: 1070-1083.
12. Papp MI, Lantos PL. The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Brain 1994; 117: 235-243.
13. Sakamoto M, Uchihara T, Nakamura A, Mizutani T, Mizusawa H. Progressive accumulation of ubiquitin and disappearance of alpha-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: triple fluorescence study combined with Gallyas-Braak method. Acta Neuropathol 2005; 110: 417-425.
14. Ozawa T, Paviour D, Quinn NP etal. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 2004; 127: 2657-2671.
15. Wakabayashi K, Ikeuchi T, Ishikawa A, Takahashi H. Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter. J Neurol Sci 1998; 156: 114-117.
16. Piao YS, Hayashi S, Hasegawa M etal. Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 2001; 101: 285-293.
17. Wakabayashi K, Mori F, Nishie M etal. An autopsy case of early ("minimal change") olivopontocerebellar atrophy (multiple system atrophy-cerebellar). Acta Neuropathol 2005; 110: 185-190.
18. Fujishiro H, Ahn TB, Frigerio R etal. Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy? Acta Neuropathol 2008; 116: 269-275.
19. Inoue M, Yagishita S, Ryo M, Hasegawa K, Amano N, Matsushita M. The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 1997; 93: 585-591.
20. Jellinger KA, Seppi K, Wenning GK. Grading of neuropathology in multiple system atrophy: proposal for a novel scale. Mov Disord 2005; 20: S29-S36.
21. Pankiv S, Clausen TH, Lamark T etal. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282: 24131-24145.
22. Schrag A, Wenning GK, Quinn N, Ben-Shlomo Y. Survival in multiple system atrophy. Mov Disord 2008; 23: 294-296.
23. Testa D, Filippini G, Farinotti M, Palazzini E, Caraceni T. Survival in multiple system atrophy: a study of prognostic factors in 59 cases. J Neurol 1996; 243: 401-404.
24. Saito Y, Matsuoka Y, Takahashi A, Ohno Y. Survival of patients with multiple system atrophy. Intern Med 1994; 33: 321-325.
25. Kume A, Takahashi A, Hashizume Y, Asai J. A histometrical and comparative study on Purkinje cell loss and olivary nucleus cell loss in multiple system atrophy. J Neurol Sci 1991; 101: 178-186.
26. Tsuchiya K, Watabiki S, Sano M etal. Distribution of cerebellar cortical lesions in multiple system atrophy: a topographic neuropathological study of three autopsy cases in Japan. J Neurol Sci 1998; 155: 80-85.
27. Fujita T, Doi M, Ogata T, Kanazawa I, Mizusawa H. Cerebral cortical pathology of sporadic olivopontocerebellar atrophy. J Neurol Sci 1993; 116: 41-46.
28. Mizutani T, Aki M, Shiozawa R etal. Development of ophthalmoplegia in amyotrophic lateral sclerosis during long-term use of respirators. J Neurol Sci 1990; 99: 311-319.
29. Nakajima M, Kojima H, Takazawa Y etal. An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan. J Clin Pathol 2009; 62: 1029-1033.