Targeting expression of the leukemogenic PML-RARα fusion protein by lentiviral vector-mediated small interfering RNA results in leukemic cell differentiation and apoptosis

Human Gene Therapy

Volumn 22, Issue 12, 2011, Pages 1593-1598

  Ward, Simone V ^a,b   Sternsdorf, Thomas ^a,c   Woods, Niels Bjarne ^a,d  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Forschungsinstitut Kinderkrebs Zentrum Hamburg   (Germany)

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; LENTIVIRUS VECTOR; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; FEMALE; GENE SILENCING; LEUKEMIA CELL; LEUKEMIA REMISSION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; SCID MOUSE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAPERITONEAL; LENTIVIRUS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; ONCOGENE PROTEINS, FUSION; RNA, SMALL INTERFERING; TRETINOIN;

EID: 83455206230     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2011.079     Document Type: Article

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