-
1
-
-
58149340104
-
Renin inhibition: Should it supplant ACE inhibitors and ARBS in high risk patients?
-
Gaddam KK, Oparil S. Renin inhibition: should it supplant ACE inhibitors and ARBS in high risk patients?. Curr Opin Nephrol Hypertens. 2008 ; 17: 484-490
-
(2008)
Curr Opin Nephrol Hypertens
, vol.17
, pp. 484-490
-
-
Gaddam, K.K.1
Oparil, S.2
-
2
-
-
0030892406
-
Angiotensin II signal transduction in vascular smooth muscle: Role of tyrosine kinases
-
Berk BC, Corson MA. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res. 1997 ; 80: 607-616 (Pubitemid 27181343)
-
(1997)
Circulation Research
, vol.80
, Issue.5
, pp. 607-616
-
-
Berk, B.C.1
Corson, M.A.2
-
3
-
-
0036840510
-
The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease
-
Volpe M, Savoia C, De Paolis P, Ostrowska B, Tarasi D, Rubattu S. The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease. J Am Soc Nephrol. 2002 ; 13: S173 - S178
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Volpe, M.1
Savoia, C.2
De Paolis, P.3
Ostrowska, B.4
Tarasi, D.5
Rubattu, S.6
-
4
-
-
53249125114
-
Renin inhibitors: Novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?
-
Pimenta E, Oparil S. Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?. Cardiol Clin. 2008 ; 26: 527-535
-
(2008)
Cardiol Clin
, vol.26
, pp. 527-535
-
-
Pimenta, E.1
Oparil, S.2
-
5
-
-
0030273707
-
The renin-angiotensin system and vascular hypertrophy
-
DOI 10.1016/S0735-1097(96)00251-3
-
Rosendorff C. The renin-angiotensin system and vascular hypertrophy. J Am Coll Cardiol. 1996 ; 28: 803-812 (Pubitemid 26348140)
-
(1996)
Journal of the American College of Cardiology
, vol.28
, Issue.4
, pp. 803-812
-
-
Rosendorff, C.1
-
6
-
-
38349128448
-
Renin inhibition in hypertension
-
Gradman AH, Kad R. Renin inhibition in hypertension. J Am Coll Cardiol. 2008 ; 51: 519-528
-
(2008)
J Am Coll Cardiol
, vol.51
, pp. 519-528
-
-
Gradman, A.H.1
Kad, R.2
-
7
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
DOI 10.1016/S0006-291X(03)01451-7
-
Wood JM, Maibaum J, Rahuel J, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003 ; 308: 698-705 (Pubitemid 36976519)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.308
, Issue.4
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
Grutter, M.G.4
Cohen, N.-C.5
Rasetti, V.6
Ruger, H.7
Goschke, R.8
Stutz, S.9
Fuhrer, W.10
Schilling, W.11
Rigollier, P.12
Yamaguchi, Y.13
Cumin, F.14
Baum, H.-P.15
Schnell, C.R.16
Herold, P.17
Mah, R.18
Jensen, C.19
O'Brien, E.20
Stanton, A.21
Bedigian, M.P.22
more..
-
8
-
-
42349086752
-
Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine
-
DOI 10.1161/HYPERTENSIONAHA.108.110932, PII 0000426820080500000012
-
Nussberger J, Aubert JF, Bouzourene K, Pellegrin M, Hayoz D, Mazzolai L. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension. 2008 ; 51: 1306-1311 (Pubitemid 351555942)
-
(2008)
Hypertension
, vol.51
, Issue.5
, pp. 1306-1311
-
-
Nussberger, J.1
Aubert, J.-F.2
Bouzourene, K.3
Pellegrin, M.4
Hayoz, D.5
Mazzolai, L.6
-
9
-
-
73949092078
-
Dynamic observation of mechanically injured mouse femoral artery reveals an antiinflammatory effect of renin inhibitor
-
Ino J, Kojima C, Osaka M, Nitta K, Yoshida M. Dynamic observation of mechanically injured mouse femoral artery reveals an antiinflammatory effect of renin inhibitor. Arterioscler Thromb Vasc Biol. 2009 ; 29: 1858-1863
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1858-1863
-
-
Ino, J.1
Kojima, C.2
Osaka, M.3
Nitta, K.4
Yoshida, M.5
-
10
-
-
40549106756
-
Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
-
DOI 10.1172/JCI32970
-
Lu H, Rateri DL, Feldman DL, et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest. 2008 ; 118: 984-993 (Pubitemid 351364606)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.3
, pp. 984-993
-
-
Lu, H.1
Rateri, D.L.2
Feldman, D.L.3
Charnigo Jr., R.J.4
Fukamizu, A.5
Ishida, J.6
Oesterling, E.G.7
Cassis, L.A.8
Daugherty, A.9
-
11
-
-
75149139972
-
Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: A pilot study
-
Cherney DZ, Lai V, Scholey JW, Miller JA, Zinman B, Reich HN. Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study. Diabetes Care. 33: 361-365
-
Diabetes Care
, vol.33
, pp. 361-365
-
-
Cherney, D.Z.1
Lai, V.2
Scholey, J.W.3
Miller, J.A.4
Zinman, B.5
Reich, H.N.6
-
12
-
-
46449118638
-
Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
-
Feldman DL, Jin L, Xuan H, et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension. 2008 ; 52: 130-136
-
(2008)
Hypertension
, vol.52
, pp. 130-136
-
-
Feldman, D.L.1
Jin, L.2
Xuan, H.3
-
13
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
DOI 10.1172/JCI200214276
-
Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002 ; 109: 1417-1427 (Pubitemid 34596167)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.11
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.-D.6
-
14
-
-
33750600468
-
Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system
-
Nabi AH, Kageshima A, Uddin MN, Nakagawa T, Park EY, Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med. 2006 ; 18: 483-488
-
(2006)
Int J Mol Med
, vol.18
, pp. 483-488
-
-
Nabi, A.H.1
Kageshima, A.2
Uddin, M.N.3
Nakagawa, T.4
Park, E.Y.5
Suzuki, F.6
-
15
-
-
35848948398
-
Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor
-
DOI 10.1097/HJH.0b013e3282f05bae, PII 0000487220071200000013
-
Batenburg WW, Krop M, Garrelds IM, et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens. 2007 ; 25: 2441-2453 (Pubitemid 350060383)
-
(2007)
Journal of Hypertension
, vol.25
, Issue.12
, pp. 2441-2453
-
-
Batenburg, W.W.1
Krop, M.2
Garrelds, I.M.3
De Vries, R.4
De Bruin, R.J.A.5
Burckle, C.A.6
Muller, D.N.7
Bader, M.8
Nguyen, G.9
Danser, A.H.J.10
-
16
-
-
39749098706
-
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
-
DOI 10.1161/HYPERTENSIONAHA.107.101444
-
Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension. 2008 ; 51: 682-688 (Pubitemid 351301521)
-
(2008)
Hypertension
, vol.51
, Issue.3
, pp. 682-688
-
-
Feldt, S.1
Batenburg, W.W.2
Mazak, I.3
Maschke, U.4
Wellner, M.5
Kvakan, H.6
Dechend, R.7
Fiebeler, A.8
Burckle, C.9
Contrepas, A.10
Danser, A.H.J.11
Bader, M.12
Nguyen, G.13
Luft, F.C.14
Muller, D.N.15
-
17
-
-
56049114004
-
Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells
-
Zhang J, Noble NA, Border WA, Owens RT, Huang Y. Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells. Am J Physiol Endocrinol Metab. 2008 ; 295: E810 - E819
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Zhang, J.1
Noble, N.A.2
Border, W.A.3
Owens, R.T.4
Huang, Y.5
-
18
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
DOI 10.1038/sj.ki.5000011, PII 5000011
-
Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006 ; 69: 105-113 (Pubitemid 43117745)
-
(2006)
Kidney International
, vol.69
, Issue.1
, pp. 105-113
-
-
Huang, Y.1
Wongamorntham, S.2
Kasting, J.3
McQuillan, D.4
Owens, R.T.5
Yu, L.6
Noble, N.A.7
Border, W.8
-
19
-
-
0033941893
-
Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
-
DOI 10.1016/S1074-5521(00)00134-4
-
Rahuel J, Rasetti V, Maibaum J, et al. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem Biol. 2000 ; 7: 493-504 (Pubitemid 30466984)
-
(2000)
Chemistry and Biology
, vol.7
, Issue.7
, pp. 493-504
-
-
Rahuel, J.1
Rasetti, V.2
Maibaum, J.3
Rueger, H.4
Goschke, R.5
Cohen, N.-C.6
Stutz, S.7
Cumin, F.8
Fuhrer, W.9
Wood, J.10
Grutter, M.G.11
-
20
-
-
70349578365
-
Fibrillar collagen inhibits cholesterol biosynthesis in human aortic smooth muscle cells
-
Ferri N, Roncalli E, Arnaboldi L, et al. Fibrillar collagen inhibits cholesterol biosynthesis in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2009 ; 29: 1631-1637
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1631-1637
-
-
Ferri, N.1
Roncalli, E.2
Arnaboldi, L.3
-
21
-
-
46449129469
-
Antihypertensive and renoprotective mechanisms of renin inhibition in diabetic rats
-
Carey RM. Antihypertensive and renoprotective mechanisms of renin inhibition in diabetic rats. Hypertension. 2008 ; 52: 63-64
-
(2008)
Hypertension
, vol.52
, pp. 63-64
-
-
Carey, R.M.1
-
22
-
-
56749090710
-
Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
-
Schefe JH, Neumann C, Goebel M, et al. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens. 2008 ; 26: 1787-1794
-
(2008)
J Hypertens
, vol.26
, pp. 1787-1794
-
-
Schefe, J.H.1
Neumann, C.2
Goebel, M.3
-
23
-
-
50349094508
-
Aliskiren
-
Brown MJ. Aliskiren. Circulation. 2008 ; 118: 773-784
-
(2008)
Circulation
, vol.118
, pp. 773-784
-
-
Brown, M.J.1
-
24
-
-
0029853814
-
Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
-
Nguyen G, Delarue F, Berrou J, Rondeau E, Sraer JD. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int. 1996 ; 50: 1897-1903 (Pubitemid 26417532)
-
(1996)
Kidney International
, vol.50
, Issue.6
, pp. 1897-1903
-
-
Nguyen, G.1
Delarue, F.2
Berrou, J.3
Rondeau, E.4
Sraer, J.-D.5
-
25
-
-
11144328072
-
1A receptor
-
DOI 10.1161/01.CIR.0000150540.54220.C4
-
Daugherty A, Rateri DL, Lu H, Inagami T, Cassis LA. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation. 2004 ; 110: 3849-3857 (Pubitemid 40023984)
-
(2004)
Circulation
, vol.110
, Issue.25
, pp. 3849-3857
-
-
Daugherty, A.1
Rateri, D.L.2
Lu, H.3
Inagami, T.4
Cassis, L.A.5
-
26
-
-
77958076732
-
Aliskiren, a renin inhibitor, downregulates TNF-alpha-induced tissue factor expression in HUVECS
-
Del Fiorentino A, Cianchetti S, Celi A, Pedrinelli R. Aliskiren, a renin inhibitor, downregulates TNF-alpha-induced tissue factor expression in HUVECS. J Renin Angiotensin Aldosterone Syst. 2010 ; 11: 243-247
-
(2010)
J Renin Angiotensin Aldosterone Syst
, vol.11
, pp. 243-247
-
-
Del Fiorentino, A.1
Cianchetti, S.2
Celi, A.3
Pedrinelli, R.4
|