메뉴 건너뛰기




Volumn 26, Issue 4, 2008, Pages 527-535

Renin Inhibitors: Novel Agents for Renoprotection or a Better Angiotensin Receptor Blocker for Blood Pressure Lowering?

Author keywords

Hypertension; Renin inhibitors; Renin angiotensin aldosterone system

Indexed keywords

ALDOSTERONE; ALISKIREN; AMLODIPINE; ANGIOTENSIN; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ATENOLOL; ATORVASTATIN; CAPTOPRIL; CELECOXIB; CGP 38560; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENALAPRILAT; ENALKIREN; HYDROCHLOROTHIAZIDE; IRBESARTAN; METFORMIN; MEVINOLIN; PEPSTATIN; RAMIPRIL; REMIKIREN; RENIN; RENIN INHIBITOR; VALSARTAN; WARFARIN; ZANKIREN;

EID: 53249125114     PISSN: 07338651     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccl.2008.06.003     Document Type: Review
Times cited : (7)

References (50)
  • 1
    • 53249135823 scopus 로고    scopus 로고
    • Pimenta E, Oparil S. Etiology and pathogenesis of systemic hypertension. In: Crawford MH, DiMarco JP, Paulus WJ, editors. Cardiology, 3rd edition. London: Mosby, in press.
    • Pimenta E, Oparil S. Etiology and pathogenesis of systemic hypertension. In: Crawford MH, DiMarco JP, Paulus WJ, editors. Cardiology, 3rd edition. London: Mosby, in press.
  • 2
    • 27444447364 scopus 로고    scopus 로고
    • Renin, pro-renin and putative (Pro)renin receptor
    • Danser A.H., and Denium J. Renin, pro-renin and putative (Pro)renin receptor. Hypertension 46 (2005) 1069-1076
    • (2005) Hypertension , vol.46 , pp. 1069-1076
    • Danser, A.H.1    Denium, J.2
  • 3
    • 0027946713 scopus 로고
    • Proteolytic processing of human pro-renin in renal and non-renal tissues
    • Reudelhuber T.L., Ramla D., Chiu L., et al. Proteolytic processing of human pro-renin in renal and non-renal tissues. Kidney Int 46 (1994) 1522-1524
    • (1994) Kidney Int , vol.46 , pp. 1522-1524
    • Reudelhuber, T.L.1    Ramla, D.2    Chiu, L.3
  • 4
    • 15144347939 scopus 로고    scopus 로고
    • Determinants of interindividual variation of renin and pro-renin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans
    • Danser A.H., Derkx F.H., Schalekamp M.A., et al. Determinants of interindividual variation of renin and pro-renin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. J Hypertens 16 (1998) 853-862
    • (1998) J Hypertens , vol.16 , pp. 853-862
    • Danser, A.H.1    Derkx, F.H.2    Schalekamp, M.A.3
  • 5
    • 0021889169 scopus 로고
    • Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complication
    • Luetscher J.A., Kraemer F.B., Wilson D.M., et al. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complication. N Engl J Med 312 (1985) 1412-1417
    • (1985) N Engl J Med , vol.312 , pp. 1412-1417
    • Luetscher, J.A.1    Kraemer, F.B.2    Wilson, D.M.3
  • 6
    • 0032709804 scopus 로고    scopus 로고
    • The paradox of the low-renin state in diabetic nephropaty
    • Price D.A., Porter L.E., Gordon M., et al. The paradox of the low-renin state in diabetic nephropaty. J Am Soc Nephrol 10 (1999) 2382-2391
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2382-2391
    • Price, D.A.1    Porter, L.E.2    Gordon, M.3
  • 7
    • 0015810741 scopus 로고
    • Antihypertensive action of propranolol: specific anti-renin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension
    • Bühler F.R., Laragh J.H., Vaughan E.D., et al. Antihypertensive action of propranolol: specific anti-renin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension. Am J Cardiol 32 (1973) 511-522
    • (1973) Am J Cardiol , vol.32 , pp. 511-522
    • Bühler, F.R.1    Laragh, J.H.2    Vaughan, E.D.3
  • 8
    • 0015289080 scopus 로고
    • The effect of chronic adrenergic receptor blockade on plasma renin activity in man
    • Michelakis A.M., and McAllister R.G. The effect of chronic adrenergic receptor blockade on plasma renin activity in man. J Clin Endocrinol Metab 34 (1972) 386-394
    • (1972) J Clin Endocrinol Metab , vol.34 , pp. 386-394
    • Michelakis, A.M.1    McAllister, R.G.2
  • 9
    • 0017578611 scopus 로고
    • Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents
    • Ondetti M.A. Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196 (1977) 441-444
    • (1977) Science , vol.196 , pp. 441-444
    • Ondetti, M.A.1
  • 10
    • 84873780743 scopus 로고
    • A bradykinin-potentiating factor present in the venom of Bothrops jararaca
    • Ferreira S.H. A bradykinin-potentiating factor present in the venom of Bothrops jararaca. Br J Pharmacol 24 (1965) 163-169
    • (1965) Br J Pharmacol , vol.24 , pp. 163-169
    • Ferreira, S.H.1
  • 11
    • 0014959663 scopus 로고
    • Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom
    • Ferreira S.H., and Greene X. Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry 9 (1970) 2583-2593
    • (1970) Biochemistry , vol.9 , pp. 2583-2593
    • Ferreira, S.H.1    Greene, X.2
  • 13
    • 38349128448 scopus 로고    scopus 로고
    • Renin inhibition in hypertension
    • Gradman A.H., and Kad R. Renin inhibition in hypertension. J Am Coll Cardiol 51 (2008) 519-528
    • (2008) J Am Coll Cardiol , vol.51 , pp. 519-528
    • Gradman, A.H.1    Kad, R.2
  • 14
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    • Pils B., Shagdarsuren E., Wellner M., et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 46 (2005) 569-576
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pils, B.1    Shagdarsuren, E.2    Wellner, M.3
  • 15
    • 33644789557 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren: where are we now, and where are we going?
    • Azizi M., Webb R., Nussberger J., et al. Renin inhibition with aliskiren: where are we now, and where are we going?. J Hypertens 24 (2006) 243-256
    • (2006) J Hypertens , vol.24 , pp. 243-256
    • Azizi, M.1    Webb, R.2    Nussberger, J.3
  • 16
    • 0024652377 scopus 로고
    • Immunological approach to blockade of the renin-substrate reaction
    • Michel J.B., Galen F.X., Guettier C., et al. Immunological approach to blockade of the renin-substrate reaction. J Hypertens 7 (1989) S63-S70
    • (1989) J Hypertens , vol.7
    • Michel, J.B.1    Galen, F.X.2    Guettier, C.3
  • 17
    • 37049229035 scopus 로고
    • Inhbition of the renin-angiotensinogen reaction by pepstatin
    • Gross F., Lazar J., and Orth H. Inhbition of the renin-angiotensinogen reaction by pepstatin. Science 175 (1972) 656
    • (1972) Science , vol.175 , pp. 656
    • Gross, F.1    Lazar, J.2    Orth, H.3
  • 18
    • 0018257849 scopus 로고
    • Soluble pepstatins: a new approach to blockade in vivo of the renin angiotensin system
    • Evin G., Gardes J., Kreft C., et al. Soluble pepstatins: a new approach to blockade in vivo of the renin angiotensin system. Clin Sci 55 (1978) 167s-171s
    • (1978) Clin Sci , vol.55
    • Evin, G.1    Gardes, J.2    Kreft, C.3
  • 19
    • 0019402245 scopus 로고
    • New renin inhibitors homologous with pepstatin
    • Eid M., Evin G., Castro B., et al. New renin inhibitors homologous with pepstatin. Biochem J 197 (1981) 465-471
    • (1981) Biochem J , vol.197 , pp. 465-471
    • Eid, M.1    Evin, G.2    Castro, B.3
  • 20
    • 0020541678 scopus 로고
    • Novel renin inhibitors containing the amino acid statine
    • Boger J., Lohr N.S., Ulm E.H., et al. Novel renin inhibitors containing the amino acid statine. Nature 303 (1983) 81-84
    • (1983) Nature , vol.303 , pp. 81-84
    • Boger, J.1    Lohr, N.S.2    Ulm, E.H.3
  • 21
    • 0020929501 scopus 로고
    • Hemodynamic effects of a competitive renin in inhibitory peptide in humans. Evidence for multiple mechanisms of action
    • Zusman R.M., Burton J., Christensen D., et al. Hemodynamic effects of a competitive renin in inhibitory peptide in humans. Evidence for multiple mechanisms of action. Trans Assoc Am Physicians 96 (1983) 365-374
    • (1983) Trans Assoc Am Physicians , vol.96 , pp. 365-374
    • Zusman, R.M.1    Burton, J.2    Christensen, D.3
  • 22
    • 0028956273 scopus 로고
    • Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans
    • Macfayden R.J., Jones C.R., Doig J.K., et al. Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans. J Cardiovasc Pharmacol 25 (1995) 347-353
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 347-353
    • Macfayden, R.J.1    Jones, C.R.2    Doig, J.K.3
  • 23
    • 0029017662 scopus 로고
    • Clinical pharamacokinetics and efficacy of renin inhibitors
    • Rongen G.A., Lenders J.W., Smits P., et al. Clinical pharamacokinetics and efficacy of renin inhibitors. Clin Pharmacokinet 29 (1995) 6-14
    • (1995) Clin Pharmacokinet , vol.29 , pp. 6-14
    • Rongen, G.A.1    Lenders, J.W.2    Smits, P.3
  • 24
    • 0030176075 scopus 로고    scopus 로고
    • Remikiren (Ro 42-5892)-an orally active renin inhibitor in essential hypertension. Effects on blood pressure and the renin-angiotensin-aldosterone system
    • Himmelmann A., Bergbrant A., Svensson A., et al. Remikiren (Ro 42-5892)-an orally active renin inhibitor in essential hypertension. Effects on blood pressure and the renin-angiotensin-aldosterone system. Am J Hypertens 9 (1996) 517-522
    • (1996) Am J Hypertens , vol.9 , pp. 517-522
    • Himmelmann, A.1    Bergbrant, A.2    Svensson, A.3
  • 25
    • 0028895715 scopus 로고
    • Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects
    • Ménard J., Boger R.S., Moyse D.M., et al. Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects. Circulation 91 (1995) 330-338
    • (1995) Circulation , vol.91 , pp. 330-338
    • Ménard, J.1    Boger, R.S.2    Moyse, D.M.3
  • 26
    • 0027381605 scopus 로고
    • Efficacy and tolerability of the renin inhibitor Ro 42-5892 in patients with hypertension
    • Rongen G.A., Lenders J.W., Kleinbloesem C.H., et al. Efficacy and tolerability of the renin inhibitor Ro 42-5892 in patients with hypertension. Clin Pharmacol Ther 54 (1993) 567-577
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 567-577
    • Rongen, G.A.1    Lenders, J.W.2    Kleinbloesem, C.H.3
  • 27
    • 0025938930 scopus 로고
    • Effect of the renin response during renin inhibition: oral Ro 42-5892 in normal humans
    • Camenzind E., Nussberger J., Juillerat L., et al. Effect of the renin response during renin inhibition: oral Ro 42-5892 in normal humans. J Cardiovasc Pharmacol 18 (1991) 299-307
    • (1991) J Cardiovasc Pharmacol , vol.18 , pp. 299-307
    • Camenzind, E.1    Nussberger, J.2    Juillerat, L.3
  • 28
    • 0024369806 scopus 로고
    • Hemodynamic and humoral effects of the new renin inhibitior enalkiren in normal humans
    • Delabays A., Nussberger J., Porchet M., et al. Hemodynamic and humoral effects of the new renin inhibitior enalkiren in normal humans. Hypertension 13 (1989) 941-947
    • (1989) Hypertension , vol.13 , pp. 941-947
    • Delabays, A.1    Nussberger, J.2    Porchet, M.3
  • 29
    • 0025302484 scopus 로고
    • Assessment of renin dependency of hypertension with a dipeptide renin inhibitor
    • Weber M.A., Neutel J.M., Essinger I., et al. Assessment of renin dependency of hypertension with a dipeptide renin inhibitor. Circulation 81 (1990) 1768-1774
    • (1990) Circulation , vol.81 , pp. 1768-1774
    • Weber, M.A.1    Neutel, J.M.2    Essinger, I.3
  • 30
    • 0026010191 scopus 로고
    • Immediate blood pressure effects of the renin inhibitor enalkiren and the ACE inhibitor enalaprilat
    • Neutel J.M., Luther R.R., Boger R.S., et al. Immediate blood pressure effects of the renin inhibitor enalkiren and the ACE inhibitor enalaprilat. Am Heart J 122 (1991) 1094-1100
    • (1991) Am Heart J , vol.122 , pp. 1094-1100
    • Neutel, J.M.1    Luther, R.R.2    Boger, R.S.3
  • 31
    • 0025370062 scopus 로고
    • Prolonged blood pressure reduction by orally active renin inhibitor RO-42-5892 in essential hypertension
    • Van den Meiracker A.H., Admiraal P.J., Man in't Veld A.J., et al. Prolonged blood pressure reduction by orally active renin inhibitor RO-42-5892 in essential hypertension. Br Med J 301 (1990) 205-210
    • (1990) Br Med J , vol.301 , pp. 205-210
    • Van den Meiracker, A.H.1    Admiraal, P.J.2    Man in't Veld, A.J.3
  • 32
    • 0024462425 scopus 로고
    • Plasma angiotensin, renin and blood pressure during acute renin inhibition by GCP 38 560A in hypertensive patients
    • Jeunemaitre X., Menard J., Nussberger J., et al. Plasma angiotensin, renin and blood pressure during acute renin inhibition by GCP 38 560A in hypertensive patients. Am J Hypertens 2 (1989) 819-827
    • (1989) Am J Hypertens , vol.2 , pp. 819-827
    • Jeunemaitre, X.1    Menard, J.2    Nussberger, J.3
  • 33
    • 33749985149 scopus 로고    scopus 로고
    • Oral renin inhibitors
    • Staessen J.A., Li Y., and Richart T. Oral renin inhibitors. Lancet 368 (2006) 1449-1456
    • (2006) Lancet , vol.368 , pp. 1449-1456
    • Staessen, J.A.1    Li, Y.2    Richart, T.3
  • 35
    • 0036372173 scopus 로고    scopus 로고
    • Angiotensin II supression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril
    • Nussberger J., Wuerzner J., Jensen C., et al. Angiotensin II supression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril. Hypertension 39 (2002) e1-e8
    • (2002) Hypertension , vol.39
    • Nussberger, J.1    Wuerzner, J.2    Jensen, C.3
  • 36
    • 4744348177 scopus 로고    scopus 로고
    • Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects
    • Dieterle W., Corynen S., Vaidyanathan S., et al. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects. Br J Clin Pharmacol 58 (2004) 433-436
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 433-436
    • Dieterle, W.1    Corynen, S.2    Vaidyanathan, S.3
  • 37
    • 28044453329 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine
    • Dieterle W., Corynen S., Vaidyanathan S., et al. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. Int J Clin Pharmacol Ther 43 (2005) 527-535
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 527-535
    • Dieterle, W.1    Corynen, S.2    Vaidyanathan, S.3
  • 38
    • 33846295862 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of the oral renin inhibitor aliskiren with hydrochlorothiazide in healthy volunteers
    • [abstract]
    • Dieterich H., Kemp C., Vaidyanathan S., et al. Pharmacokinetic interaction of the oral renin inhibitor aliskiren with hydrochlorothiazide in healthy volunteers. Clin Pharmacol Ther 79 (2006) P12 [abstract]
    • (2006) Clin Pharmacol Ther , vol.79
    • Dieterich, H.1    Kemp, C.2    Vaidyanathan, S.3
  • 39
    • 33749850285 scopus 로고    scopus 로고
    • Aliskiren, the first in a new class or orally effective renin inhibitors, has no clinically significant drug interactions with digoxin in healthy volunteers
    • [abstract]
    • Dieterich H., Kemp C., Vaidyanathan S., et al. Aliskiren, the first in a new class or orally effective renin inhibitors, has no clinically significant drug interactions with digoxin in healthy volunteers. Clin Pharmacol Ther 79 (2006) P64 [abstract]
    • (2006) Clin Pharmacol Ther , vol.79
    • Dieterich, H.1    Kemp, C.2    Vaidyanathan, S.3
  • 40
    • 9644287897 scopus 로고    scopus 로고
    • Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Azizi M., Ménard J., Bissery A., et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 15 (2004) 3126-3133
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3126-3133
    • Azizi, M.1    Ménard, J.2    Bissery, A.3
  • 41
    • 26244440599 scopus 로고    scopus 로고
    • Complement activation in angiotensin II-induced organ damage
    • Shagdarsuren E., Wellner M., Braesen J.H., et al. Complement activation in angiotensin II-induced organ damage. Circ Res 97 (2005) 716-724
    • (2005) Circ Res , vol.97 , pp. 716-724
    • Shagdarsuren, E.1    Wellner, M.2    Braesen, J.H.3
  • 42
    • 34848907212 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropaty in rats
    • Kelly D.J., Zhang Y., Moe G., et al. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropaty in rats. Diabetologia 50 (2007) 2398-2404
    • (2007) Diabetologia , vol.50 , pp. 2398-2404
    • Kelly, D.J.1    Zhang, Y.2    Moe, G.3
  • 43
    • 43449139264 scopus 로고    scopus 로고
    • Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes
    • Persson F., Rossing P., Schjoedt K.J., et al. Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes. Kidney Int 73 12 (2008) 1419-1425
    • (2008) Kidney Int , vol.73 , Issue.12 , pp. 1419-1425
    • Persson, F.1    Rossing, P.2    Schjoedt, K.J.3
  • 44
    • 14844363404 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective rennin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    • Gradman A.H., Schmieder R.E., Lins R.L., et al. Aliskiren, a novel orally effective rennin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 111 (2005) 1012-1018
    • (2005) Circulation , vol.111 , pp. 1012-1018
    • Gradman, A.H.1    Schmieder, R.E.2    Lins, R.L.3
  • 45
    • 33947182655 scopus 로고    scopus 로고
    • Aliskiren, an oral rennin inhibitor, provides dose-dependent efficacy and sustained 24-h blood pressure control in patients with hypertension
    • Oh B.H., Mitchell J., Herron J.R., et al. Aliskiren, an oral rennin inhibitor, provides dose-dependent efficacy and sustained 24-h blood pressure control in patients with hypertension. J Am Coll Cardiol 49 (2007) 1157-1163
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1157-1163
    • Oh, B.H.1    Mitchell, J.2    Herron, J.R.3
  • 46
    • 36348998335 scopus 로고    scopus 로고
    • Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension
    • [abstract]
    • Dahlöf B., Anderson D.R., Arora V., et al. Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension. J Clin Hypertens 9 (2007) A157 [abstract]
    • (2007) J Clin Hypertens , vol.9
    • Dahlöf, B.1    Anderson, D.R.2    Arora, V.3
  • 47
    • 39849089447 scopus 로고    scopus 로고
    • Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial
    • Andersen K., Weinberger M.H., Egan B., et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens 26 (2008) 589-599
    • (2008) J Hypertens , vol.26 , pp. 589-599
    • Andersen, K.1    Weinberger, M.H.2    Egan, B.3
  • 48
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • Villamil A., Chysant S.G., Calhoun D., et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 25 (2007) 217-226
    • (2007) J Hypertens , vol.25 , pp. 217-226
    • Villamil, A.1    Chysant, S.G.2    Calhoun, D.3
  • 49
    • 34447521458 scopus 로고    scopus 로고
    • Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomized double-blind trial
    • Oparil S., Yarows S.A., Patel S., et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomized double-blind trial. Lancet 370 (2007) 221-229
    • (2007) Lancet , vol.370 , pp. 221-229
    • Oparil, S.1    Yarows, S.A.2    Patel, S.3
  • 50
    • 34247644329 scopus 로고    scopus 로고
    • Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness
    • Sealey J.E., and Laragh J.H. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens 20 (2007) 587-597
    • (2007) Am J Hypertens , vol.20 , pp. 587-597
    • Sealey, J.E.1    Laragh, J.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.