Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's sydrome. A role in the control of vascular tone and implication for hypertension

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 8, 2004, Pages 4153-4157

  Calò, Lorenzo A ^a   Pagnin, Ellsa ^a   Davls, Paul A ^b   Sartori, Michelangelo ^a   Ceolotto, Giulio ^a   Pessina, Achille C ^a   Semplicini, Andrea ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CYCLIC GMP; MESSENGER RNA; NITRIC OXIDE; RGS PROTEIN; RGS2 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BARTTER SYNDROME; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; GITELMAN SYNDROME; HUMAN; HUMAN CELL; HYPERTENSION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; URINARY EXCRETION;

ADULT; ANGIOTENSIN II; BARTTER SYNDROME; CASE-CONTROL STUDIES; COHORT STUDIES; CREATININE; CYCLIC GMP; FEMALE; GENE EXPRESSION; HUMANS; HYPERTENSION; MIDDLE AGED; MONOCYTES; NITRATES; NITRITES; RGS PROTEINS; RNA, MESSENGER; VASOMOTOR SYSTEM;

EID: 4043103612     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0498     Document Type: Article

References (23)

1. Lifton RP, Gharavi AG and Geller DS 2001 Molecular mechanisms of human hypertension. Cell 104:545-556,
2. Hepler RJ 1999 Emerging roles for RGS proteins in cell signalling. TIPS 20:376-382
3. Zhong H and Neubig RR 2001 Regulator of G protein signalling proteins; novel multifunctional drug targets. J Pharmacol Exp Ther 297:837-845
4. Ross EM and Wilkie TM 2000 GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827
5. Heximer SP, Knutsen RH, Sun X, Kaltenbroon KM, Rhee MH, Peng N, Oliveira dos Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wiss JM, Mecham RP and Blumer KJ 2003 Hypertension and prolonged vasoconstrictor signalling in RGS2-deficient mice. J Clin Invest 111:445-452
6. Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME 2003 Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9:1506-1512
7. Calò L, Davis PA, Semplicini A 2000 Control of vascular tone in the syndromes of Bartter and Gitelman. Crit Rev Clin Lab Sci 37:503-522
8. Calò L, Ceolotto G, Milani M, Pagnin E, van den Heuvel LP, Sartori M, Davis PA, Costa R, Semplicini A 2001 Abnormalities of Gq-mediated cell signaling in Bartter and Gitelman syndromes. Kidney Int 60:882-889
9. Calò L, Davis PA, Semplicini A 2002 Reduced content of alpha subunit of Gq protein in monocytes of Bartter and Gitelman syndromes: Relationship with vascular hyporeactivity. Kidney Int 61:353-354
10. Calò LA, Pagnin E, Davis PA, Sartori M and Semplicini A 2003 Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling. Nephrol Dial Transplant 18:1518-1525
11. Calò L, D'Angelo A, Cantaro S, Rizzolo M, Favaro S, Antonello A and Borsatti A 1996 Intracellular calcium signalling and vascular reactivity in Bartter's syndrome. Nephron 72:570-573
12. Di Virgilio F, Calò L, Cantaro S, Favaro S, Piccoli A. and Borsatti A 1987 Resting and stimulated cytosolic free calcium levels in neutrophils from patients with Bartter's syndrome. Clin Sci 72:483-488
13. Calò L, Davis PA, Semplicini A 2003 Bartter's/Gitelman's syndrome: a model for the relationships between hypertension, angiotensin II, oxidative stress and remodeling. Clin Nephrol 59:393-394,
14. Hebert SC 2003 Bartter syndrome. Curr Opin Nephrol Hypertens 12:527-532
15. Beadling C, Druey KM, Richter G, Kehrl JH and Smith KA 1999 Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes. J Immunol 162:2677-2682
16. - evaluation by an ion chromatography system. Biomedical Chromatography 12:97-98
17. Grant SL, Lassegue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander RW 2000 Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells. Mol. Pharmacol 57:460-467
18. Bartter FC 1981 Bartter's syndrome: a disorder of vascular reactivity. Hypertension 3(suppl. I): I-69-I-73
19. Dzau VJ 2001 Tissue angiotensin and pathobiology of vascular disease. A unifying hypothesis. Hypertension 37:1047-1052
20. Calò L, Davis PA, Milani M, Cantaro S, Antonello A, Favaro S, D'Angelo A 1999 Increased endothelial nitric oxide synthase mRNA level in Bartter's and Gitelman's syndrome. Relationship to vascular reactivity. Clin Nephrol 1:10-17
21. Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O, Tetradis S 2002 Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3′, 5′-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 30:677-684
22. Stoff JS, Stemerman M, Steer M, Salzman E, Brown RS 1980 A defect in platelet aggregation in Bartter's syndrome. Am J Med 68:171-180
23. Cunningham ML, Waldo GL, Hollinger S, Helper JR, Harden TK 2001 Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. J Biol Chem 276:5438-5444