Formation of droplet networks that function in aqueous environments

Nature Nanotechnology

Volumn 6, Issue 12, 2011, Pages 803-808

  Villar, Gabriel ^a   Heron, Andrew J ^a,b   Bayley, Hagan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Oxford Nanopore Technologies Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; LIPID BILAYERS; PHASE INTERFACES; PROTEINS; SYNTHETIC BIOLOGY; TISSUE;

AQUEOUS DROPLETS; AQUEOUS ENVIRONMENT; BIOLOGY AND MEDICINE; ELECTRICAL COMPONENTS; FUNCTIONAL NETWORK; LIPID MONOLAYER; MEMBRANE PROTEINS; PHYSIOLOGICAL ENVIRONMENT;

DROPS;

OIL; WATER;

AQUEOUS SOLUTION; ARTICLE; NANOENCAPSULATION; NUCLEAR PORE; PH; PRIORITY JOURNAL; TEMPERATURE;

EID: 83455192382     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2011.183     Document Type: Article

References (35)

1. Funakoshi, K., Suzuki, H. & Takeuchi, S. Lipid bilayer formation by contacting monolayers in a microfluidic device for membrane protein analysis. Anal. Chem. 78, 8169-8174 (2006). (Pubitemid 44927591)
2. Holden, M. A., Needham, D. & Bayley, H. Functional bionetworks from nanoliter water droplets. J. Am. Chem. Soc. 129, 8650-8655 (2007). (Pubitemid 47066529)
3. Heron, A. J., Thompson, J. R., Mason, A. E. & Wallace, M. I. Direct detection of membrane channels from gels using water-in-oil droplet bilayers. J. Am. Chem. Soc. 129, 16042-16047 (2007).
4. Syeda, R., Holden, M. A., Hwang, W. L. & Bayley, H. Screening blockers against a potassium channel with a droplet interface bilayer array. J. Am. Chem. Soc. 130, 15543-15548 (2008).
5. Heron, A. J., Thompson, J. R., Cronin, B., Bayley, H. & Wallace, M. I. Simultaneous measurement of ionic current and fluorescence from single protein pores. J. Am. Chem. Soc. 131, 1652-1653 (2009).
6. Maglia, G. et al. Droplet networks with incorporated protein diodes show collective properties. Nature Nanotech. 4, 437-440 (2009).
7. Woolfson, D. N. & Bromley, E. H. C. Synthetic biology. The Biochemist 19-25 (February 2011).
8. Channon, K., Bromley, E. H. C. & Woolfson, D. N. Synthetic biology through biomolecular design and engineering. Curr. Opin. Struct. Biol. 18, 491-498 (2008).
9. Solé, R. V., Munteanu, A., Rodriguez-Caso, C. & Mac?́a, J. Synthetic protocell biology: from reproduction to computation. Phil. Trans. R. Soc. B 362, 1727-1739 (2007). (Pubitemid 47547180)
10. Walker, S. A., Kennedy, M. T. & Zasadzinski, J. A. Encapsulation of bilayer vesicles by self-assembly. Nature 387, 61-64 (1997). (Pubitemid 27202647)
11. Kim, S., Turker, M. S., Chi, E. Y., Sela, S. & Martin, G. M. Preparation of multivesicular liposomes. Biochim. Biophys. Acta Biomembranes 728, 339-348 (1983).
12. Yue, B. Y., Jackson, C. M., Taylor, J. A. G., Mingins, J. & Pethica, B. A. Phospholipid monolayers at non-polar oil/water interfaces. Part 1-Phase transitions in distearoyl-lecithin films at the n-heptane aqueous sodium chloride interface. J. Chem. Soc. Farad. Trans. I 72, 2685-2693 (1976).
13. Morisaku, T., Yui, H. & Sawada, T. Development of a new experimental system for monitoring biomembrane reactions: combination of laser spectroscopic techniques and biomembrane models formed at an oil/water interface. Anal. Sci. 20, 1605-1608 (2004).
14. Needham, D. & Haydon, D. A. Tensions and free energies of formation of 'solventless' lipid bilayers-measurement of high contact angles. Biophys. J. 41, 251-257 (1983). (Pubitemid 13082068)
15. Stoddart, D., Heron, A. J., Mikhailova, E., Maglia, G. & Bayley, H. Singlenucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc. Natl Acad. Sci. USA 106, 7702-7707 (2009).
16. Gu, L.-Q. & Bayley, H. Interaction of the noncovalent molecular adapter, b-cyclodextrin, with the staphylococcal a-hemolysin pore. Biophys. J. 79, 1967-1975 (2000).
17. Drummond, D. C., Zignani, M. & Leroux, J.-C. Current status of pH-sensitive liposomes in drug delivery. Prog. Lipid Res. 39, 409-460 (2000).
18. Hamilton, J. A. & Cistola, D. P. Transfer of oleic acid between albumin and phospholipid vesicles. Proc. Natl Acad. Sci. USA 83, 82-86 (1986). (Pubitemid 16141619)
19. Small, D. M., Cabral, D. J., Cistola, D. P., Parks, J. S. & Hamilton, J. A. The ionization behavior of fatty acids and bile acids in micelles and membranes. Hepatology 4, 77S-79S (1984). (Pubitemid 14018148)
20. Mills, J. K. & Needham, D. Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. Biochim. Biophys. Acta Biomembranes 1716, 77-96 (2005). (Pubitemid 41532286)
21. Nakagawa, S., Maeda, S. & Tsukihara, T. Structural and functional studies of gap junction channels. Curr. Opin. Struct. Biol. 20, 423-430 (2010).
22. Strambio-De-Castillia, C., Niepel, M. & Rout, M. P. The nuclear pore complex: bridging nuclear transport and gene regulation. Nature Rev. Mol. Cell Biol. 11, 490-501 (2010).
23. Needham, D. & Dewhirst, M. W. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv. Drug Deliv. Rev. 53, 285-305 (2001). (Pubitemid 34024911)
24. Rautio, J. et al. Prodrugs: design and clinical applications. Nature Rev. Drug Discov. 7, 255-270 (2008). (Pubitemid 351324639)
25. Devine, D. V., Wong, K., Serrano, K., Chonn, A. & Cullis, P. R. Liposomecomplement interactions in rat serum: implications for liposome survival studies. Biochim. Biophys. Acta Biomembranes 1191, 43-51 (1994). (Pubitemid 24133527)
26. Okushima, S., Nisisako, T., Torii, T. & Higuchi, T. Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices. Langmuir 20, 9905-9908 (2004).
27. Chu, L.-Y., Utada, A. S., Shah, R. K., Kim, J.-W. & Weitz, D. A. Controllable monodisperse multiple emulsions. Angew. Chem. Int. Ed. 46, 8970-8974 (2007). (Pubitemid 350232746)
28. Seo, M., Paquet, C., Nie, Z., Xu, S. & Kumacheva, E. Microfluidic consecutive flow-focusing droplet generators. Soft Matter 3, 986-992 (2007). (Pubitemid 47118902)
29. Shum, H. C., Zhao, Y., Kim, S.-H. & Weitz, D. A. Multicompartment polymersomes from double emulsions. Angew. Chem. Int. Ed. 50, 1648-1651 (2011).
30. Debinski, W. & Tatter, S. B. Convection-enhanced delivery for the treatment of brain tumors. Exp. Rev. Neurother. 9, 1519-1527 (2009).
31. Larsen, C. et al. Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. J. Pharm. Sci. 97, 4622-4654 (2008).
32. Cheley, S. et al. Spontaneous oligomerization of a staphylococcal a-hemolysin conformationally constrained by removal of residues that form the transmembrane b-barrel. Protein Eng. 10, 1433-1443 (1997). (Pubitemid 28116183)
33. Maglia, G., Heron, A. J., Stoddart, D., Japrung, D. & Bayley, H. Analysis of single nucleic acid molecules with protein nanopores. Methods Enzymol. 475, 591-623 (2010).
34. Maglia, G. et al. DNA strands from denatured duplexes are translocated through engineered protein nanopores at alkaline pH. Nano Lett. 9, 3831-3836 (2009).
35. Abràmoff, M. D., Magalhães, P. J. & Ram, S. J. Image processing with ImageJ. Biophoton. Int. 11, 36-42 (2004).