Discovery of a novel series of CRTH2 (DP2) receptor antagonists devoid of carboxylic acids

ACS Medicinal Chemistry Letters

Volumn 2, Issue 12, 2011, Pages 938-942

  Crosignani, Stefano ^a   Jorand Lebrun, Catherine ^a   Campbell, Gordon ^a   Prêtre, Adeline ^a   Grippi Vallotton, Tania ^a   Quattropani, Anna ^a   Bouscary Desforges, Gwenaelle ^a   Bombrun, Agnes ^a   Missotten, Marc ^a   Humbert, Yves ^a   Frémaux, Christèle ^a   Pâquet, Mikaël ^a   El Harkani, Kamel ^a   Bradshaw, Charles G ^a   Cleva, Christophe ^a   Abla, Nada ^a   Daff, Hamina ^a   Schott, Olivier ^a   Pittet, Pierre André ^a   Arrighi, Jean François ^a   Gaudet, Marilène ^a   Johnson, Zoë ^a   more..

^a MERCK SERONO S A   (Switzerland)

Author keywords

antagonists; asthma; CRTH2 (DP2) receptor; tetrazoles

Indexed keywords

CRTH2 RECEPTOR ANTAGONIST; CYTOCHROME P450 2C9; FLUORINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG CLEARANCE; DRUG EFFECT; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 83455172849     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200223s     Document Type: Article

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