Application of mass spectrometry to the structural identification of the metabolites of the synthetic cannabinoid JWH-018 and the determination of them in human urine

Journal of Analytical Chemistry

Volumn 66, Issue 13, 2011, Pages 1314-1323

  Sobolevskii, T G ^a   Prasolov, I S ^a   Rodchenkov, G M ^a  

^a Antidoping Center   (Russian Federation)

Author keywords

GC MS; HPLC MS; JWH 018; metabolism; smoking mixtures; synthetic cannabinoids

Indexed keywords

CANNABINOIDS; ELECTRON IONIZATION; FORENSIC TOXICOLOGY; GC/MS; GLUCURONIC ACIDS; HPLC/MS; HUMAN URINE; IN-VIVO; INDOLE RINGS; JWH-018; PARENT COMPOUNDS; SIDE-CHAINS; STRUCTURAL IDENTIFICATION; SYNTHETIC CANNABINOID; TANDEM MASS SPECTROMETRY; URINARY METABOLITES;

BIOMOLECULES; BODY FLUIDS; GAS CHROMATOGRAPHY; GLUCOSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IONIZATION OF GASES; MASS SPECTROMETRY; METABOLITES; PHYSIOLOGY;

METABOLISM;

EID: 83455172751     PISSN: 10619348     EISSN: None     Source Type: Journal    
DOI: 10.1134/S1061934811130090     Document Type: Article

References (10)

1. Postanovlenie Pravitel'stva Rossiiskoi Federatsii ot 31 dekabrya 2009 g. No. 1186 "O vnesenii izmenenii v nekotorye postanovleniya Pravitel'stva Rossiiskoi Federatsii po voprosam, svyazannym s oborotom narkoticheskikh sredstv (Resolution of the Government of the Russian Federation no. 1186 of December 31, 2009, 'On Amendments to Some of the Resolutions of the Government of the Russian Federation on Issues Related to Circulation of Drugs'), 2010. http://www.rg.ru/2010/0l/14/narko-dok.html. Accessed March 31, 2010.
2. Understanding the 'spice' Phenomenon, Lisbon: European Monitoring Centre for Drugs and Drug Addiction, 2009. http://www.emcdda.europa.eu/html.cfm/ index90917EN.html. Accessed March 31, 2010.
3. Steup, C.; Untersuchung des Handelsproduktes 'spice'. http://usualredant.de/drogen/download/analyse-thc-pharm-spice-jwh-018.pdf. Accessed March 31, 2010.
4. Synthetic Cannabinoids and 'spice', Lisbon: European Monitoring Centre for Drugs and Drug Addiction, 2009. http://www.emcdda.europa.eu/html.cfm/ index90414EN.html. Accessed March 31, 2010.
5. R. Lindigkeit A. Boehme I. Eiserloh M. Luebbecke M. Wiggermann L. Ernst T. Beuerle 2009 Forensic Sci. Int 191 s.1-3 58 10.1016/j.forsciint.2009.06.008 1:CAS:528:DC%2BD1MXhtFSnsLvJ
6. Q. Zhang P. Ma R.B. Cole 2006 Anal. Bioanal. Chem. 386 1345 10.1007/s00216-006-0717-6 1:CAS:528:DC%2BD28XhtFegtLvJ (Pubitemid 44657764)
7. N. Uchiyama R. Kikura-Hanajiri N. Kawahara Y. Goda 2009 Forensic Toxicol. 27 2 61 10.1007/s11419-009-0069-y 1:CAS:528:DC%2BD1MXos1Cgsrs%3D
8. N. Uchiyama R. Kikura-Hanajiri N. Kawahara Y. Haishima Y. Goda 2009 Chem. Pharm. Bull. 57 4 439 10.1248/cpb.57.439 1:CAS:528:DC%2BD1MXmtl2qu74%3D
9. Rust, K.Y, Meyer, M.R.; Weissenbach, D.K.; Bregel, D.; Hopf, M.; Maurer, H.H.; and Wilske, J.; Proc. 47th Annual Meeting of the Int. Assoc. of Forensic Toxicologists, Geneva, 2009, p. 21. http://www.ata-journal. org/articles/ata/ pdf/2009/02/ata2009s102.pdf. Accessed March 31, 2010.
10. V. Auwarter S. Dresen W. Weinmann M. Muller M. Putz N. Ferreiros 2009 J. Mass Spectrom. 44 5 832 10.1002/jms.1558