Locally applied platelet-derived growth factor accelerates fracture healing

Journal of Bone and Joint Surgery - Series B

Volumn 93 B, Issue 12, 2011, Pages 1653-1659

  Bordei, P ^a  

^a OVIDIUS UNIVERSITY   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; PLATELET DERIVED GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALLUS; CELL PROLIFERATION; CONTROLLED STUDY; FRACTURE HEALING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOGRAPHY; RAT;

ABSORBABLE IMPLANTS; ANIMALS; BROMODEOXYURIDINE; CASE-CONTROL STUDIES; COATED MATERIALS, BIOCOMPATIBLE; DISEASE MODELS, ANIMAL; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; HINDLIMB; MALE; OSTEOBLASTS; PLATELET-DERIVED GROWTH FACTOR; POLYESTERS; RADIATION-SENSITIZING AGENTS; RATS; RATS, SPRAGUE-DAWLEY; TIBIAL FRACTURES; TIME FACTORS;

EID: 83455170754     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.93B12.27244     Document Type: Article

References (28)

1. Tonna EA, Cronkite EP. Cellular response to fracture studied with tritiated thymidine. J Bone Joint Surg [Am] 1961;43-A:352-362.
2. Iwaki A, Jingushi S, Oda Y, et al. Localization and quantification of proliferating cells during rat fracture repair: detection of proliferating cell nuclear antigen by immunohistochemistry. J Bone Miner Res 1997;12:96-102. (Pubitemid 27053617)
3. Trippel S, Coutts R, Einhorn T, Mundy R, Rosenfeld R. Growth factors as therapeutic agents. J Bone Joint Surg [Am] 1996;78-A:1272-1286.
4. Kasperk CH, Wergedal JE, Mohan S, et al. Interactions of growth factors present in bone matrix with bone cells: effects on DNA synthesis and alkaline phosphatase. Growth Factors 1990;3:147-158.
5. Boden SD. Growth factor-based technologies. Procs American Academy of Orthopaedic Surgeons 75th Annual Meeting. San Francisco, March 2008.
6. Bourque WT, Gross M, Hall BK. Expression of four growth factors during fracture repair. Int J Devel Biol 1993;37:573-579. (Pubitemid 24063759)
7. Preilschifter J, Oechsner M, Naumann A, et al. Stimulation of bone matrix apposition in vitro by local growth factors: a comparison between insulin-like growth factor I, platelet-derived growth factor and transforming growth factor beta. Endocrinology 1990;127:69-75. (Pubitemid 20228102)
8. McCarthy HS, Williams JH, Davie MW, Marshall MJ. Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cell. J Cell Physiol 2009;218:350-354.
9. Wildemann B, Schmidmaier G, Ordel S, et al. Cell proliferation and differentiation during fracture healing are influenced by locally applied IGF-I and TGF-β1: comparison of two proliferation markers, PCNA and BrdU. J Biomed Mater Res Part B Appl Biomater 2003;65:150-156. (Pubitemid 37521387)
10. Zegzula HD, Buck DC, Brekke J, et al. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J Bone Joint Surg [Am] 1997;79-A:1778-1790.
11. Zapf J, Hauri C, Waldvogel M, Froesch ER. Acute metabolic effects and halflives of intravenously administered insulin-like growth factors I and II in normal and hypophysectomized rats. J Clin Invest 1986;77:1768-1775. (Pubitemid 16062628)
12. Schmidmaier G, Wildemann B, Bail H, et al. Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-β1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone 2001;28:341-350. (Pubitemid 32390106)
13. Gratzner HG. Monoclonal antibody to 5-bromo- and 5-iodode-oxyuridine: a new reagent for detection of DNA replication. Science 1982;218:474-475. (Pubitemid 12000901)
14. Schmidmaier G, Wildemann B, Cromme F, et al. Bone morphogenetic protein- 2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. Bone 2002;30:816-822. (Pubitemid 34616007)
15. Hoffmann JE, Schmidmaier G, Duda GN, Raschke M. Ein neues standardisiertes Frakturmodell an der Ratte. Der Unfallchirurg 1999;281(Suppl):275 (in German).
16. Biederbick A, Elsasser H. Diurnal pattern of rat pancreatic acinar cell replication. Cell Tissue Res 1998;291:277-283. (Pubitemid 28081851)
17. Gaglia P, Bernardi A, Venesio T, et al. Cell proliferation of breast cancer evaluated by anti-BrdU and anti-Ki-67 antibodies: its prognostic value on short-term recurrences. Eur J Cancer 1993;29:1509-1513. (Pubitemid 23251787)
18. Gerhart TN, Kirker-Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 1993;293:317-326. (Pubitemid 23242887)
19. Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth factor expression in normally healing human fractures. Bone 1995;16:455-460.
20. Rydziel S, Canalis E. Expression and growth factor regulation of platelet-derived growth factor B transcripts in primary osteoblast cell cultures. Endocrinology 1996;137:4115-4119. (Pubitemid 26321854)
21. Yu X, Hsieh SC, Bao W, Graves DT. Temporal expression of PDGF receptors and PDGF regulatory effects on osteoblastic cells in mineralizing cultures. Am J Physiol 1997;272:C1709-C1C16.
22. Nash TJ, Howlett CR, Martin C, et al. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15:203-208. (Pubitemid 24116085)
23. Mitlak BH, Finkelman RD, Hill EL, et al. The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 1996;11:238-247. (Pubitemid 26057432)
24. Welch RD, Jones AL, Bucholz RW, et al. Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J Bone Miner Res 1998;13:1483-1490. (Pubitemid 28418916)
25. Bax BE, Wozney JM, Ashhurst DE. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int 1999;65:83-89. (Pubitemid 29293533)
26. Baltzer AW, Lattermann C, Whalen JD, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 2000;7:734-739. (Pubitemid 30255754)
27. Lieberman JR, Daluiski A, Stevenson S, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg [Am] 1999;81-A:905-917. (Pubitemid 29354999)
28. Zellin G, Linde A. Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes: an experimental study using rhBMP-2 in rat mandibular defects. J Biomed Mater Res 1997;35:181-190. (Pubitemid 27188283)