Regulatory use of (Q)SARs in toxicological hazard assessment strategies

SAR and QSAR in Environmental Research

Volumn 15, Issue 5-6, 2004, Pages 359-366

  Gerner, I ^a   Spielmann, H ^a   Hoefer, T ^a   Liebsch, M ^a   Herzler, M ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

(Q)SARs for assessment of human health hazards; Eye irritation corrosion; Regulatory assessment strategies; Replacement of animal tests; Skin irritation corrosion; Skin sensitisation

Indexed keywords

ANIMALS; CHEMICAL HAZARDS; CLASSIFICATION (OF INFORMATION); DECISION SUPPORT SYSTEMS; EXPERT SYSTEMS; FORECASTING; RISK ASSESSMENT;

(Q)SAR FOR ASSESSMENT OF HUMAN HEALTH HAZARD; ANIMAL TESTS; ASSESSMENT STRATEGIES; EYE IRRITATION/CORROSION; HUMAN HEALTH; REGULATORY ASSESSMENT; REGULATORY ASSESSMENT STRATEGY; REPLACEMENT OF ANIMAL TEST; SKIN IRRITATION; SKIN IRRITATION/CORROSION; SKIN SENSITIZATION;

HEALTH HAZARDS;

ANIMALIA;

EID: 8344287063     PISSN: 1062936X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10629360412331297335     Document Type: Conference Paper

References (15)

1. Cronin, M.T.D., Jaworska, J.S., Walker, J.D., Comber, M.H.I., Watts, C.D. and Worth, A.P. (2003) "Use of QSARs in international decision-making frameworks to predict health effects of chemical substances", Environ. Health Perspect. 111(10), 1391-1401.
2. Schultz, T. W., Cronin, M.T.D. and Netzeva, T.I. (2003) "The present status of QSAR in toxicology", J. Mol. Struct. (Theochem.) 622, 23-38.
3. Combes, R., Barratt, M. and Balls, M. (2003) "An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH system", ATLA 31, 7-19.
4. Hoefer, T., Gerner, I., Gundert-Remy, U., Liebsch, M., Schulte, A., Spielmann, H., Vogel, R. and Wettig, K. (2004) "Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation", Arch. Toxicol., In press.
5. Gerner, I., Graetschel, G., Kahl, J. and Schiede, E. (2000) "Development of a decision support system for the introduction of alternative methods into local irritation/corrosion testing strategies: development of a relational data base", ATLA 28, 11-28.
6. Gerner, I., Zinke, S., Graetschel, G. and Schiede, E. (2000) "Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies: creation of fundamental rules for a decision support system", ATLA 28, 665-698.
7. Gerner, I., Barratt, M.D., Zinke, S., Schlegel, K. and Schiede, E. (2004) "Development and pre-validation of a list of SAR rules to be used in expert systems for the prediction of skin sensitising properties of chemicals", ATLA, In press.
8. Hulzebos, E.T., Walker, J.D., Gerner, I. and Schlegel, K. (2004) "Application of skin irritation and corrosivity (Q)SARs 3. Use of 'structural alerts' to develop rules for identifying chemical substances with skin irritation or corrosion potential", QSAR Comb. Sci., in press.
9. Spielmann, H., Gerner, I., Liebsch, M. (2005) "Assessment of eye irritating properties of chemicals applying alternatives to the Draize rabbit eye test" (Submitted).
10. Gerner, I., Schlegel, K., Walker, J.D. and Hulzebos, E. (2004) "Application of skin irritation and corrosion (Q)SARs 2. Use of physicochemical property limits to develop rules for identifying chemical substances with no skin irritation or corrosion potential", QSAR Comb. Sci., in press.
11. Gerner, I. and Schlede, E. (2002) "Introduction of in vitro data into local irritation/corrosion testing strategies by means of SAR considerations: assessment of chemicals", Toxicol. Lett. 127, 169-175.
12. Walker, J.D., Gerner, I., Hulzebos, E. and Schlegel, K. (2004) "Application of skin irritation and corrosion (Q)SARs 1. Mechanistic and transparency considerations", QSAR Comb. Sci., Submitted.
13. Zinke, S., Gerner, I., Graetschel, G. and Schiede, E. (2000) "Local irritation/corrosion testing strategies: development of a decision support system for the introduction of alternative methods", ATLA 28, 29-40.
14. Balls, M., Blaauboer, B.J., Fentem, J.H., Bruner, L., Combes, R.D., Ekwall, B., Fielder, R.J., Guillouzo, A., Lewis, R.W., Lovell, D.P., Reinhardt, C.A., Repetto, G., Sladowski, D., Spielmann, H. and Zucco, F. (1995) "Practical aspects of the validation of toxicity test procedures. The report and recommendations of ECVAM workshop 5", ATLA 23, 129-147.
15. CEFIC (2002) (European Chemical Industry Council). "Report from the workshop on regulatory acceptance of QSARs for human health and environmental endpoints", Setubal, Portugal, March 4-6, 2002. Report available from rbu@cefic.be