Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 11, 2004, Pages 2149-2154

  Morello, Fulvio ^a   De Bruin, Tjerk W A ^b   Rotter, Jerome I ^c   Pratt, Richard E ^a   Van Der Kallen, Carla J H ^b   Hladik, Gary A ^c   Dzau, Victor J ^a   Liew, Choong Chin ^a,d   Chen, Yii Der I ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Blood cells; Dyslipidemia; Genetics; Genomics; Microarray

Indexed keywords

7 DEHYDROCHOLESTEROL; 7 DEHYDROCHOLESTEROL REDUCTASE; CYTIDINE DIPHOSPHATE DIGLYCERIDE; CYTIDINE DIPHOSPHATE DIGLYCERIDE SYNTHASE 2; EARLY GROWTH RESPONSE FACTOR 1; GANGLIOSIDE GM2; IDITOL DEHYDROGENASE; ISOMERASE; LIPOYLTRANSFERASE; LYSOPHOSPHOLIPASE 3; MANNOSIDASE; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL GLYCAN CLASS C; PHOSPHOPROTEIN PHOSPHATASE 2A; RIBOSE 5 PHOSPHATE; RIBOSE 5 PHOSPHATE ISOMERASE A; TRANSFERASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD CELL; CDS2 GENE; CELL CULTURE; CLINICAL ARTICLE; DCHR 7 GENE; DNA MICROARRAY; EGR1 GENE; FAMILIAL COMBINED HYPERLIPIDEMIA; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GM2A GENE; HUMAN; HYPERLIPIDEMIA; LIPT1 GENE; LYPLA2 GENE; MALE; MAN2C1 GENE; PIGC GENE; PPP2R1B GENE; PRIORITY JOURNAL; RPIA GENE; SORD GENE;

CELLS, CULTURED; CLUSTER ANALYSIS; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES; HUMANS; HYPERLIPIDEMIA, FAMILIAL COMBINED; IMMEDIATE-EARLY PROTEINS; LYMPHOCYTES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTORS;

EID: 8344246114     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000145978.70872.63     Document Type: Article

References (31)

1. Genest JJ Jr, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH, Silberman SR, Wilson PW, Salem DN, Schaefer EJ. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation. 1992;85:2025-2033.
2. Austin MA, McKnight B, Edwards KL, Bradley CM, McNeely MJ, Psaty BM, Brunzell JD, Motulsky AG. Cardiovascular disease mortality in familial forms of hypertriglyceridemia: a 20-year prospective study. Circulation. 2000;101:2777-2782.
3. Voors-Pette C, de Bruin TW. Excess coronary heart disease in familial combined hyperlipidemia, in relation to genetic factors and central obesity. Atherosclerosis. 2001;157:481-489.
4. Hopkins PN, Heiss G, Ellison RC, Province MA, Pankow JS, Eckfeldt JH, Hunt SC. Coronary artery disease risk in familial combined hyperlipidemia and familial bypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation. 2003;108:519-523.
5. de Graaf J, Stalenhoef AF. Defects of lipoprotein metabolism in familial combined hyperlipidaemia. Curr Opin Lipidol. 1998;9:189-196.
6. Vakkilainen J, Porkka KV, Nuotio I, Pajukanta P, Suurinkeroinen L, Ylitalo K, Viikari JS, Ehnholm C, Taskinen MR. Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group. European J Clin Invest. 1998;28:24-32.
7. Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest. 1973;52:1544-1568.
8. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately down-regulated in human diabetes. Nat Genet. 2003;34:267-273.
9. Hwang JJ, Allen PD, Tseng GC, Lam CW, Fananapazir L, Dzau VJ, Liew CC. Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genom. 2002;10:31-44.
10. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bemards R. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002;347:1999-2009.
11. Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, Seilhamer JJ, Vaughan AM, Oram JF. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-R31.
12. van der Kallen CJ, Cantor RM, van Greevenbroek MM, Geurts JM, Bouwman FG, Aouizerat BE, Allayee H, Buurman WA, Lusis AJ, Rotter JI, de Bruin TW. Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. Int J Obesity Related Metab Dis: J Int Assoc Study Obesity. 2000;24:1381-1391.
13. Pressman S, Rotter JI. Epstein-Barr Virus transformation of cryopreserved lymphocytes: prolonged experience with the technique. Am J Hum Genet. 1991;49:467.
14. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001;98:5116-5121.
15. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25:25-29.
16. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol. 2003;4:R70.
17. Eurlings PM, Van Der Kallen CJ, Geurts JM, Kouwenberg P, Boeckx WD, De Bruin TW. Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia. J Lipid Res. 2002;43:930-935.
18. McCaffrey TA. TGF-betas and TGF-beta receptors in atherosclerosis. Cytokine Growth Factor Rev. 2000;11:103-114.
19. Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE. Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene. 2003;315:33-41.
20. Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA. Delayed hepatocellular mitotic progression and impaired liver regeneration in early-growth-response-1 deficient mice. J Biol Chem. 2004.
21. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988;53:37-43.
22. Zhang F, Ahlborn TE, Li C, Kraemer FB, Liu J. Identification of Egr1 as the oncostatin M-induced transcription activator that binds to sterol-independent regulatory element of human LDL receptor promoter. J Lipid Res. 2002;43:1477-1485.
23. Cui L, Schoene NW, Zhu L, Fanzo JC, Alshatwi A, Lei KY. Zinc depletion reduced Egr-1 and HNF-3β expression and apolipoprotein A-I promoter activity in Hep G2 cells. Am Journal of Physiology - Cell Physiology. 2002;283:C623-C630.
24. Kilbourne EJ, Widom R, Harnish DC, Malik S, Karathanasis SK. Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription. J Biol Chem. 1995;270:7004-7010.
25. Naoumova RP, Bonney SA, Eichenbaum-Voline S, Patel HN, Jones B, Jones EL, Amey J, Colilla S, Neuwirth CK, Allotey R, Seed M, Betteridge DJ, Galton DJ, Cox NJ, Bell GI, Scott J, Shoulders CC. Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2003;23:2070-2077.
26. Dallinga-Thie GM, van Linde-Sibenius Trip M, Rotter JI, Cantor RM, Bu X, Lusis AJ, de Bruin TW. Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes. J Clin Invest. 1997;99:953-961.
27. Gagnon F, Jarvik GP, Motulsky AG, Deeb SS, Brunzell JD, Wijsman EM. Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment. Hum Genet. 2003;113:522-533.
28. Fitzky BU, Witsch-Baumgartner M, Erdel M, Lee JN, Paik YK, Glossmann H, Utermann G, Moebius FF. Mutations in the Delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci USA. 1998;95:8181-8186.
29. Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M. Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. Biochem Biophysl Res Commun. 1999;257:50-56.
30. Hiraoka M, Abe A, Shayman JA. Cloning and characterization of a lysosomal phospholipase A2, I-O-acylceramide synthase. J Biol Chem. 2002;277:10090-10099.
31. Georgieva AM, van Greevenbroek MM, Krauss RM, Brouwers MC, Vermeulen VM, Robertus-Teunissen MG, van der Kallen CJ, de Bruin TW. Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype. Arterioscler Thromb Vasc Biol. 2004;24:744-749.