-
1
-
-
0035822038
-
The hemophilias-from royal genes to gene therapy
-
Mannucci P.M., Tuddenham E.G. The hemophilias-from royal genes to gene therapy. N Engl J Med 2001, 344:1773-1779.
-
(2001)
N Engl J Med
, vol.344
, pp. 1773-1779
-
-
Mannucci, P.M.1
Tuddenham, E.G.2
-
2
-
-
8844263239
-
Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX
-
Lollar P. Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX. J Thromb Haemost 2004, 2:1082-1095.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 1082-1095
-
-
Lollar, P.1
-
3
-
-
0032787813
-
Incidence of inhibitors in haemophilia A patients-a review of recent studies of recombinant and plasma-derived factor VIII concentrates
-
Scharrer I., Bray G.L., Neutzling O. Incidence of inhibitors in haemophilia A patients-a review of recent studies of recombinant and plasma-derived factor VIII concentrates. Haemophilia 1999, 5:145-154.
-
(1999)
Haemophilia
, vol.5
, pp. 145-154
-
-
Scharrer, I.1
Bray, G.L.2
Neutzling, O.3
-
4
-
-
34250708408
-
Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A
-
Gouw S.C., van den Berg H.M., le Cessie S., van der Bom J.G. Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A. J Thromb Haemost 2007, 5:1383-1390.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 1383-1390
-
-
Gouw, S.C.1
van den Berg, H.M.2
le Cessie, S.3
van der Bom, J.G.4
-
5
-
-
0029617930
-
Haemophilia A: mutation type determines risk of inhibitor formation
-
Schwaab R., Brackmann H.H., Meyer C., Seehafer J., Kirchgesser M., Haack A., et al. Haemophilia A: mutation type determines risk of inhibitor formation. Thromb Haemost 1995, 74:1402-1406.
-
(1995)
Thromb Haemost
, vol.74
, pp. 1402-1406
-
-
Schwaab, R.1
Brackmann, H.H.2
Meyer, C.3
Seehafer, J.4
Kirchgesser, M.5
Haack, A.6
-
6
-
-
0031856834
-
The genetic basis of inhibitor development in haemophilia A
-
Tuddenham E.G., McVey J.H. The genetic basis of inhibitor development in haemophilia A. Haemophilia 1998, 4:543-545.
-
(1998)
Haemophilia
, vol.4
, pp. 543-545
-
-
Tuddenham, E.G.1
McVey, J.H.2
-
7
-
-
33645751563
-
Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A
-
Astermark J., Oldenburg J., Pavlova A., Berntorp E., Lefvert A.K. Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A. Blood 2006, 107:3167-3172.
-
(2006)
Blood
, vol.107
, pp. 3167-3172
-
-
Astermark, J.1
Oldenburg, J.2
Pavlova, A.3
Berntorp, E.4
Lefvert, A.K.5
-
8
-
-
33845239946
-
Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A
-
Astermark J., Oldenburg J., Carlson J., Pavlova A., Kavakli K., Berntorp E., et al. Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood 2006, 108:3739-3745.
-
(2006)
Blood
, vol.108
, pp. 3739-3745
-
-
Astermark, J.1
Oldenburg, J.2
Carlson, J.3
Pavlova, A.4
Kavakli, K.5
Berntorp, E.6
-
9
-
-
33846420672
-
Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A
-
Astermark J., Wang X., Oldenburg J., Berntorp E., Lefvert A.K. Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A. J Thromb Haemost 2007, 5:263-265.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 263-265
-
-
Astermark, J.1
Wang, X.2
Oldenburg, J.3
Berntorp, E.4
Lefvert, A.K.5
-
10
-
-
0031048881
-
Factor VIII inhibitors in previously treated haemophilia A patients with a double virus-inactivated plasma derived factor VIII concentrate
-
Peerlinck K., Arnout J., Di Giambattista M., Gilles J.G., Laub R., Jacquemin M., et al. Factor VIII inhibitors in previously treated haemophilia A patients with a double virus-inactivated plasma derived factor VIII concentrate. Thromb Haemost 1997, 77:80-86.
-
(1997)
Thromb Haemost
, vol.77
, pp. 80-86
-
-
Peerlinck, K.1
Arnout, J.2
Di Giambattista, M.3
Gilles, J.G.4
Laub, R.5
Jacquemin, M.6
-
11
-
-
34249711370
-
Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
-
Gouw S.C., van der Bom J.G., Auerswald G., Ettinghausen C.E., Tedgard U., van den Berg H.M. Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study. Blood 2007, 109:4693-4697.
-
(2007)
Blood
, vol.109
, pp. 4693-4697
-
-
Gouw, S.C.1
van der Bom, J.G.2
Auerswald, G.3
Ettinghausen, C.E.4
Tedgard, U.5
van den Berg, H.M.6
-
12
-
-
0036797443
-
Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients
-
Reding M.T., Lei S., Lei H., Green D., Gill J., Conti-Fine B.M. Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients. Thromb Haemost 2002, 88:568-575.
-
(2002)
Thromb Haemost
, vol.88
, pp. 568-575
-
-
Reding, M.T.1
Lei, S.2
Lei, H.3
Green, D.4
Gill, J.5
Conti-Fine, B.M.6
-
13
-
-
47649116958
-
IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A
-
van Helden P.M., van den Berg H.M., Gouw S.C., Kaijen P.H., Zuurveld M.G., Mauser-Bunschoten E.P., et al. IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A. Br J Haematol 2008, 142:644-652.
-
(2008)
Br J Haematol
, vol.142
, pp. 644-652
-
-
van Helden, P.M.1
van den Berg, H.M.2
Gouw, S.C.3
Kaijen, P.H.4
Zuurveld, M.G.5
Mauser-Bunschoten, E.P.6
-
14
-
-
0023274159
-
FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting
-
Fulcher C.A., de Graaf M.S., Zimmerman T.S. FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood 1987, 69:1475-1480.
-
(1987)
Blood
, vol.69
, pp. 1475-1480
-
-
Fulcher, C.A.1
de Graaf, M.S.2
Zimmerman, T.S.3
-
15
-
-
0024379471
-
Disappearance of inhibitor to factor VIII in HIV-infected hemophiliacs with progression to AIDS or severe ARC
-
Ragni M.V., Bontempo F.A., Lewis J.H. Disappearance of inhibitor to factor VIII in HIV-infected hemophiliacs with progression to AIDS or severe ARC. Transfusion 1989, 29:447-449.
-
(1989)
Transfusion
, vol.29
, pp. 447-449
-
-
Ragni, M.V.1
Bontempo, F.A.2
Lewis, J.H.3
-
16
-
-
17644370329
-
Cell biology of antigen processing in vitro and in vivo
-
Trombetta E.S., Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 2005, 23:975-1028.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 975-1028
-
-
Trombetta, E.S.1
Mellman, I.2
-
17
-
-
39149120572
-
Endocytosis mechanisms and the cell biology of antigen presentation
-
Burgdorf S., Kurts C. Endocytosis mechanisms and the cell biology of antigen presentation. Curr Opin Immunol 2008, 20:89-95.
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 89-95
-
-
Burgdorf, S.1
Kurts, C.2
-
18
-
-
33644764063
-
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
-
Lakadamyali M., Rust M.J., Zhuang X. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 2006, 124:997-1009.
-
(2006)
Cell
, vol.124
, pp. 997-1009
-
-
Lakadamyali, M.1
Rust, M.J.2
Zhuang, X.3
-
19
-
-
33846244931
-
VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors
-
Dasgupta S., Repesse Y., Bayry J., Navarrete A.M., Wootla B., Delignat S., et al. VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. Blood 2007, 109:610-612.
-
(2007)
Blood
, vol.109
, pp. 610-612
-
-
Dasgupta, S.1
Repesse, Y.2
Bayry, J.3
Navarrete, A.M.4
Wootla, B.5
Delignat, S.6
-
20
-
-
52649093281
-
Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo
-
van Schooten C.J., Shahbazi S., Groot E., Oortwijn B.D., van den Berg H.M., Denis C.V., et al. Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo. Blood 2008, 112:1704-1712.
-
(2008)
Blood
, vol.112
, pp. 1704-1712
-
-
van Schooten, C.J.1
Shahbazi, S.2
Groot, E.3
Oortwijn, B.D.4
van den Berg, H.M.5
Denis, C.V.6
-
21
-
-
70449431508
-
Splenic marginal zone antigen presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A
-
Navarrete A., Dasgupta S., Delignat S., Caligiuri G., Christophe O.D., Bayry J., et al. Splenic marginal zone antigen presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A. J Thromb Haemost 2009, 7:1816-1823.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 1816-1823
-
-
Navarrete, A.1
Dasgupta, S.2
Delignat, S.3
Caligiuri, G.4
Christophe, O.D.5
Bayry, J.6
-
22
-
-
79957975266
-
HLA-DR-presented peptide-repertoires derived from human monocyte-derived dendritic cells pulsed with blood coagulation factor VIII
-
M110.002246
-
van Haren S.D., Herczenik E., Ten Brinke A., Mertens K., Voorberg J., Meijer A.B. HLA-DR-presented peptide-repertoires derived from human monocyte-derived dendritic cells pulsed with blood coagulation factor VIII. Mol Cell Proteomics 2011, 10. M110.002246.
-
(2011)
Mol Cell Proteomics
, vol.10
-
-
van Haren, S.D.1
Herczenik, E.2
Ten Brinke, A.3
Mertens, K.4
Voorberg, J.5
Meijer, A.B.6
-
23
-
-
34547430130
-
A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes
-
Dasgupta S., Navarrete A.M., Bayry J., Delignat S., Wootla B., Andre S., et al. A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes. Proc Natl Acad Sci U S A 2007, 104:8965-8970.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8965-8970
-
-
Dasgupta, S.1
Navarrete, A.M.2
Bayry, J.3
Delignat, S.4
Wootla, B.5
Andre, S.6
-
25
-
-
84856486915
-
-
Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain J Allergy Clin Immunol 2011 Sep 29. [Epub ahead of print].
-
Herczenik E, Van Haren SD, Wroblewska A, Kaijen P, van den Biggelaar M, Meijer A, et al. Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain J Allergy Clin Immunol 2011 Sep 29. [Epub ahead of print].
-
-
-
Herczenik, E.1
Van Haren, S.D.2
Wroblewska, A.3
Kaijen, P.4
Van den Biggelaar, M.5
Meijer, A.6
-
26
-
-
0034161385
-
Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice
-
Schwarz H.P., Lenting P.J., Binder B., Mihaly J., Denis C., Dorner F., et al. Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. Blood 2000, 95:1703-1708.
-
(2000)
Blood
, vol.95
, pp. 1703-1708
-
-
Schwarz, H.P.1
Lenting, P.J.2
Binder, B.3
Mihaly, J.4
Denis, C.5
Dorner, F.6
-
27
-
-
29144495242
-
Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis
-
Cunningham N., Laffan M.A., Manning R.A., O'Donnell J.S. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. Blood Coagul Fibrinolysis 2005, 16:465-468.
-
(2005)
Blood Coagul Fibrinolysis
, vol.16
, pp. 465-468
-
-
Cunningham, N.1
Laffan, M.A.2
Manning, R.A.3
O'Donnell, J.S.4
-
28
-
-
77951036167
-
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4(+) memory T cells
-
Fischer N., Haug M., Kwok W.W., Kalbacher H., Wernet D., Dannecker G.E., et al. Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4(+) memory T cells. Eur J Immunol 2010, 40(4):986-997.
-
(2010)
Eur J Immunol
, vol.40
, Issue.4
, pp. 986-997
-
-
Fischer, N.1
Haug, M.2
Kwok, W.W.3
Kalbacher, H.4
Wernet, D.5
Dannecker, G.E.6
-
29
-
-
70450277084
-
Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation
-
Singh S.K., Stephani J., Schaefer M., Kalay H., Garcia-Vallejo J.J., den Haan J., et al. Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation. Mol Immunol 2009, 47:164-174.
-
(2009)
Mol Immunol
, vol.47
, pp. 164-174
-
-
Singh, S.K.1
Stephani, J.2
Schaefer, M.3
Kalay, H.4
Garcia-Vallejo, J.J.5
den Haan, J.6
-
30
-
-
38549178456
-
Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation
-
Dasgupta S., Navarrete A.M., Andre S., Wootla B., Delignat S., Repesse Y., et al. Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica 2008, 93:83-89.
-
(2008)
Haematologica
, vol.93
, pp. 83-89
-
-
Dasgupta, S.1
Navarrete, A.M.2
Andre, S.3
Wootla, B.4
Delignat, S.5
Repesse, Y.6
-
31
-
-
0035853843
-
Cell surface heparan sulfate proteoglycans participate in factor VIII catabolism mediated by low density lipoprotein receptor-related protein
-
Sarafanov A.G., Ananyeva N.M., Shima M., Saenko E.L. Cell surface heparan sulfate proteoglycans participate in factor VIII catabolism mediated by low density lipoprotein receptor-related protein. J Biol Chem 2001, 276:11970-11979.
-
(2001)
J Biol Chem
, vol.276
, pp. 11970-11979
-
-
Sarafanov, A.G.1
Ananyeva, N.M.2
Shima, M.3
Saenko, E.L.4
-
32
-
-
0033695299
-
Proteolysis in MHC class II antigen presentation: who's in charge?
-
Villadangos J.A., Ploegh H.L. Proteolysis in MHC class II antigen presentation: who's in charge?. Immunity 2000, 12:233-239.
-
(2000)
Immunity
, vol.12
, pp. 233-239
-
-
Villadangos, J.A.1
Ploegh, H.L.2
-
33
-
-
0031568395
-
Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms
-
Griffin J.P., Chu R., Harding C.V. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. J Immunol 1997, 158:1523-1532.
-
(1997)
J Immunol
, vol.158
, pp. 1523-1532
-
-
Griffin, J.P.1
Chu, R.2
Harding, C.V.3
-
34
-
-
0027370367
-
Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment
-
Harding C.V., Geuze H.J. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J Immunol 1993, 151:3988-3998.
-
(1993)
J Immunol
, vol.151
, pp. 3988-3998
-
-
Harding, C.V.1
Geuze, H.J.2
-
35
-
-
34648817211
-
The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization
-
Ten Brinke A., Karsten M.L., Dieker M.C., Zwaginga J.J., van Ham S.M. The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization. Vaccine 2007, 25:7145-7152.
-
(2007)
Vaccine
, vol.25
, pp. 7145-7152
-
-
Ten Brinke, A.1
Karsten, M.L.2
Dieker, M.C.3
Zwaginga, J.J.4
van Ham, S.M.5
-
36
-
-
0033999502
-
Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro
-
Lutz M.B., Kukutsch N.A., Menges M., Rossner S., Schuler G. Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur J Immunol 2000, 30:1048-1052.
-
(2000)
Eur J Immunol
, vol.30
, pp. 1048-1052
-
-
Lutz, M.B.1
Kukutsch, N.A.2
Menges, M.3
Rossner, S.4
Schuler, G.5
-
37
-
-
56749158179
-
Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells
-
Qadura M., Othman M., Waters B., Chegeni R., Walker K., Labelle A., et al. Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemost 2008, 6:2095-2104.
-
(2008)
J Thromb Haemost
, vol.6
, pp. 2095-2104
-
-
Qadura, M.1
Othman, M.2
Waters, B.3
Chegeni, R.4
Walker, K.5
Labelle, A.6
-
38
-
-
0031057651
-
HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A UKHCDO Inhibitor Working Party
-
Hay C.R., Ollier W., Pepper L., Cumming A., Keeney S., Goodeve A.C., et al. HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A UKHCDO Inhibitor Working Party. Thromb Haemost 1997, 77:234-237.
-
(1997)
Thromb Haemost
, vol.77
, pp. 234-237
-
-
Hay, C.R.1
Ollier, W.2
Pepper, L.3
Cumming, A.4
Keeney, S.5
Goodeve, A.C.6
-
39
-
-
0031045680
-
HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII
-
Oldenburg J., Picard J.K., Schwaab R., Brackmann H.H., Tuddenham E.G., Simpson E. HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII. Thromb Haemost 1997, 77:238-242.
-
(1997)
Thromb Haemost
, vol.77
, pp. 238-242
-
-
Oldenburg, J.1
Picard, J.K.2
Schwaab, R.3
Brackmann, H.H.4
Tuddenham, E.G.5
Simpson, E.6
-
40
-
-
12744278383
-
Epitope repertoire of human CD4(+) T cells on the A3 domain of coagulation factor VIII
-
Reding M.T., Okita D.K., Diethelm-Okita B.M., Anderson T.A., Conti-Fine B.M. Epitope repertoire of human CD4(+) T cells on the A3 domain of coagulation factor VIII. J Thromb Haemost 2004, 2:1385-1394.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 1385-1394
-
-
Reding, M.T.1
Okita, D.K.2
Diethelm-Okita, B.M.3
Anderson, T.A.4
Conti-Fine, B.M.5
-
41
-
-
1642295197
-
Human CD4+ T-cell epitope repertoire on the C2 domain of coagulation factor VIII
-
Reding M.T., Okita D.K., Diethelm-Okita B.M., Anderson T.A., Conti-Fine B.M. Human CD4+ T-cell epitope repertoire on the C2 domain of coagulation factor VIII. J Thromb Haemost 2003, 1:1777-1784.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1777-1784
-
-
Reding, M.T.1
Okita, D.K.2
Diethelm-Okita, B.M.3
Anderson, T.A.4
Conti-Fine, B.M.5
-
42
-
-
79953294918
-
T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site
-
James E.A., van Haren S.D., Ettinger R.A., Fijnvandraat K., Liberman J.A., Kwok W.W., et al. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site. J Thromb Haemost 2011, 9:689-699.
-
(2011)
J Thromb Haemost
, vol.9
, pp. 689-699
-
-
James, E.A.1
van Haren, S.D.2
Ettinger, R.A.3
Fijnvandraat, K.4
Liberman, J.A.5
Kwok, W.W.6
-
43
-
-
36349021392
-
T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide
-
James E.A., Kwok W.W., Ettinger R.A., Thompson A.R., Pratt K.P. T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide. J Thromb Haemost 2007, 5:2399-2407.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 2399-2407
-
-
James, E.A.1
Kwok, W.W.2
Ettinger, R.A.3
Thompson, A.R.4
Pratt, K.P.5
-
44
-
-
0037441590
-
CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A
-
Jacquemin M., Vantomme V., Buhot C., Lavend'homme R., Burny W., Demotte N., et al. CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A. Blood. 2003, 101:1351-1358.
-
(2003)
Blood.
, vol.101
, pp. 1351-1358
-
-
Jacquemin, M.1
Vantomme, V.2
Buhot, C.3
Lavend'homme, R.4
Burny, W.5
Demotte, N.6
-
45
-
-
23844439692
-
Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII
-
Jones T.D., Phillips W.J., Smith B.J., Bamford C.A., Nayee P.D., Baglin T.P., et al. Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII. J Thromb Haemost 2005, 3:991-1000.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 991-1000
-
-
Jones, T.D.1
Phillips, W.J.2
Smith, B.J.3
Bamford, C.A.4
Nayee, P.D.5
Baglin, T.P.6
-
46
-
-
33748586497
-
Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells
-
Pfistershammer K., Stockl J., Siekmann J., Turecek P.L., Schwarz H.P., Reipert B.M. Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells. Thromb Haemost 2006, 96:309-316.
-
(2006)
Thromb Haemost
, vol.96
, pp. 309-316
-
-
Pfistershammer, K.1
Stockl, J.2
Siekmann, J.3
Turecek, P.L.4
Schwarz, H.P.5
Reipert, B.M.6
-
47
-
-
73949090509
-
A role for thrombin in the initiation of the immune response to therapeutic Factor VIII
-
Skupsky J., Zhang A.H., Su Y., Scott D.W. A role for thrombin in the initiation of the immune response to therapeutic Factor VIII. Blood 2009, 114:4741-4748.
-
(2009)
Blood
, vol.114
, pp. 4741-4748
-
-
Skupsky, J.1
Zhang, A.H.2
Su, Y.3
Scott, D.W.4
-
48
-
-
0033825674
-
Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titer
-
Qian J., Burkly L.C., Smith E.P., Ferrant J.L., Hoyer L.W., Scott D.W., et al. Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titer. Eur J Immunol 2000, 30:2548-2554.
-
(2000)
Eur J Immunol
, vol.30
, pp. 2548-2554
-
-
Qian, J.1
Burkly, L.C.2
Smith, E.P.3
Ferrant, J.L.4
Hoyer, L.W.5
Scott, D.W.6
-
49
-
-
0035655711
-
Blockade of CD40/CD40 ligand interactions prevents induction of factor VIII inhibitors in hemophilic mice but does not induce lasting immune tolerance
-
Reipert B.M., Sasgary M., Ahmad R.U., Auer W., Turecek P.L., Schwarz H.P. Blockade of CD40/CD40 ligand interactions prevents induction of factor VIII inhibitors in hemophilic mice but does not induce lasting immune tolerance. Thromb Haemost 2001, 86:1345-1352.
-
(2001)
Thromb Haemost
, vol.86
, pp. 1345-1352
-
-
Reipert, B.M.1
Sasgary, M.2
Ahmad, R.U.3
Auer, W.4
Turecek, P.L.5
Schwarz, H.P.6
-
50
-
-
0029983837
-
Immune regulation by CD40 and its ligand GP39
-
Foy T.M., Aruffo A., Bajorath J., Buhlmann J.E., Noelle R.J. Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 1996, 14:591-617.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 591-617
-
-
Foy, T.M.1
Aruffo, A.2
Bajorath, J.3
Buhlmann, J.E.4
Noelle, R.J.5
-
51
-
-
0032751201
-
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
-
Honey K., Cobbold S.P., Waldmann H. CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression. J Immunol 1999, 163:4805-4810.
-
(1999)
J Immunol
, vol.163
, pp. 4805-4810
-
-
Honey, K.1
Cobbold, S.P.2
Waldmann, H.3
-
52
-
-
0035353196
-
Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A
-
Rossi G., Sarkar J., Scandella D. Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A. Blood 2001, 97:2750-2757.
-
(2001)
Blood
, vol.97
, pp. 2750-2757
-
-
Rossi, G.1
Sarkar, J.2
Scandella, D.3
-
53
-
-
24044517504
-
Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex
-
Purohit V.S., Ramani K., Sarkar R., Kazazian H.H., Balasubramanian S.V. Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex. J Biol Chem 2005, 280:17593-17600.
-
(2005)
J Biol Chem
, vol.280
, pp. 17593-17600
-
-
Purohit, V.S.1
Ramani, K.2
Sarkar, R.3
Kazazian, H.H.4
Balasubramanian, S.V.5
-
54
-
-
12444275550
-
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo
-
Hoffmann P.R., Kench J.A., Vondracek A., Kruk E., Daleke D.L., Jordan M., et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol 2005, 174:1393-1404.
-
(2005)
J Immunol
, vol.174
, pp. 1393-1404
-
-
Hoffmann, P.R.1
Kench, J.A.2
Vondracek, A.3
Kruk, E.4
Daleke, D.L.5
Jordan, M.6
-
55
-
-
0026785721
-
Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles
-
Duffy E.J., Parker E.T., Mutucumarana V.P., Johnson A.E., Lollar P. Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles. J Biol Chem 1992, 267:17006-17011.
-
(1992)
J Biol Chem
, vol.267
, pp. 17006-17011
-
-
Duffy, E.J.1
Parker, E.T.2
Mutucumarana, V.P.3
Johnson, A.E.4
Lollar, P.5
-
56
-
-
70449709337
-
Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity
-
Meems H., Meijer A.B., Cullinan D.B., Mertens K., Gilbert G.E. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood 2009, 114:3938-3946.
-
(2009)
Blood
, vol.114
, pp. 3938-3946
-
-
Meems, H.1
Meijer, A.B.2
Cullinan, D.B.3
Mertens, K.4
Gilbert, G.E.5
-
57
-
-
79952837716
-
Membrane binding properties of the factor VIII C2 domain
-
Novakovic V.A., Cullinan D.C., Wakabayashi H., Fay P., Baleja J.D., Gilbert G.E. Membrane binding properties of the factor VIII C2 domain. Biochem J 2011, 435:187-196.
-
(2011)
Biochem J
, vol.435
, pp. 187-196
-
-
Novakovic, V.A.1
Cullinan, D.C.2
Wakabayashi, H.3
Fay, P.4
Baleja, J.D.5
Gilbert, G.E.6
-
58
-
-
78650939162
-
Dendritic cells in networks of immunological tolerance
-
Gregori S. Dendritic cells in networks of immunological tolerance. Tissue Antigens 2011, 77:89-99.
-
(2011)
Tissue Antigens
, vol.77
, pp. 89-99
-
-
Gregori, S.1
-
59
-
-
34547152610
-
Tolerogenic dendritic cells and the quest for transplant tolerance
-
Morelli A.E., Thomson A.W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007, 7:610-621.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 610-621
-
-
Morelli, A.E.1
Thomson, A.W.2
-
60
-
-
0038036797
-
Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
-
Hackstein H., Taner T., Zahorchak A.F., Morelli A.E., Logar A.J., Gessner A., et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003, 101:4457-4463.
-
(2003)
Blood
, vol.101
, pp. 4457-4463
-
-
Hackstein, H.1
Taner, T.2
Zahorchak, A.F.3
Morelli, A.E.4
Logar, A.J.5
Gessner, A.6
-
61
-
-
13144256708
-
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
-
Taner T., Hackstein H., Wang Z., Morelli A.E., Thomson A.W. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant 2005, 5:228-236.
-
(2005)
Am J Transplant
, vol.5
, pp. 228-236
-
-
Taner, T.1
Hackstein, H.2
Wang, Z.3
Morelli, A.E.4
Thomson, A.W.5
-
62
-
-
34249805413
-
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
-
Turnquist H.R., Raimondi G., Zahorchak A.F., Fischer R.T., Wang Z., Thomson A.W. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007, 178:7018-7031.
-
(2007)
J Immunol
, vol.178
, pp. 7018-7031
-
-
Turnquist, H.R.1
Raimondi, G.2
Zahorchak, A.F.3
Fischer, R.T.4
Wang, Z.5
Thomson, A.W.6
-
63
-
-
80051585518
-
Tolerance induction to factor VIII by transient co-administration with rapamycin
-
Moghimi B., Sack B.K., Nayak S., Markusic D.M., Mah C.S., Herzog R.W. Tolerance induction to factor VIII by transient co-administration with rapamycin. J Thromb Haemost 2011, 9:1524-1533.
-
(2011)
J Thromb Haemost
, vol.9
, pp. 1524-1533
-
-
Moghimi, B.1
Sack, B.K.2
Nayak, S.3
Markusic, D.M.4
Mah, C.S.5
Herzog, R.W.6
-
64
-
-
0033203120
-
Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
-
Rodriguez A., Regnault A., Kleijmeer M., Ricciardi-Castagnoli P., Amigorena S. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nat Cell Biol 1999, 1:362-368.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 362-368
-
-
Rodriguez, A.1
Regnault, A.2
Kleijmeer, M.3
Ricciardi-Castagnoli, P.4
Amigorena, S.5
-
65
-
-
0035838984
-
Dendritic cells: specialized and regulated antigen processing machines
-
Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001, 106:255-258.
-
(2001)
Cell
, vol.106
, pp. 255-258
-
-
Mellman, I.1
Steinman, R.M.2
-
66
-
-
35448975265
-
Factor VIII-specific memory B cells in patients with hemophilia A
-
van Helden P.M., Kaijen P.H., Fijnvandraat K., van den Berg H.M., Voorberg J. Factor VIII-specific memory B cells in patients with hemophilia A. J Thromb Haemost 2007, 5:2306-2308.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 2306-2308
-
-
van Helden, P.M.1
Kaijen, P.H.2
Fijnvandraat, K.3
van den Berg, H.M.4
Voorberg, J.5
-
67
-
-
77955176519
-
B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cells
-
Skupsky J., Zhang A.H., Su Y., Scott D.W. B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cells. Mol Ther 2010, 18:1527-1535.
-
(2010)
Mol Ther
, vol.18
, pp. 1527-1535
-
-
Skupsky, J.1
Zhang, A.H.2
Su, Y.3
Scott, D.W.4
-
68
-
-
20444476217
-
Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins
-
Lei T.C., Scott D.W. Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins. Blood 2005, 105:4865-4870.
-
(2005)
Blood
, vol.105
, pp. 4865-4870
-
-
Lei, T.C.1
Scott, D.W.2
-
69
-
-
41449117525
-
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex
-
Ngo J.C., Huang M., Roth D.A., Furie B.C., Furie B. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure 2008, 16:597-606.
-
(2008)
Structure
, vol.16
, pp. 597-606
-
-
Ngo, J.C.1
Huang, M.2
Roth, D.A.3
Furie, B.C.4
Furie, B.5
|