Cyclosporine-induced interstitial fibrosis and arteriolar TGF-β expression with preserved renal blood flow

Transplantation

Volumn 68, Issue 11, 1999, Pages 1746-1753

  Vieira Jr , José M ^d   Noronha, Irene L ^a   Malheiros, Denise M A C ^a   Burdmann, Emmanuel A ^a,b,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Santa Casa de Misericórdia de São José Do Rio Preto Hospital   (Brazil)

^c FACULDADE DE MEDICINA DE SÃO JOSÉ DO RIO PRETO   (Brazil)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BLOOD FLOW; KIDNEY FIBROSIS; KIDNEY TRANSPLANTATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033573118     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199912150-00019     Document Type: Article

References (45)

1. Opelz G. Collaborative transplant study - 10 year report. Transplant Proc 1992; 24: 2342.
2. Myers BD, Sibley R, Newton L, et al. The long-term course of cyclosporine-associated chronic nephropathy. Kidney Int 1988; 33: 590.
3. Goldstein DJ, Zuech N, Sehgal V, Weinberg AD, Drusin R, Cohen D. Cyclosporine-associated end-stage nephropathy after cardiac transplantation. Transplantation 1997; 63: 664.
4. Feutren G, Mihatsch MJ, International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. N Engl J Med 1992; 326: 1654.
5. Sund S, Forre O, Berg KJ, Kvien TK, Hovig T. Morphological and functional renal effects of long-term low-dose cyclosporin: a treatment in patients with rheumatoid arthritis. Clin Nephrol 1994; 41: 33.
6. English J, Evan A, Houghton DC, Bennett WM. Cyclosporine-induced acute renal dysfunction in the rat: evidence of arteriolar vasoconstriction with preservation of tubular function. Transplantation 1987; 44: 135.
7. Curtis JJ, Luke RG, Dubovsky E, Diethelm AG, Whelchel JD, Jones P. Cyclosporin in therapeutic doses increases renal allograft vascular resistance. Lancet 1986; 2: 477.
8. Barros EJ, Boim MA, Ajzen H, Ramos OL, Schor N. Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity. Kidney Int 1987; 32: 19.
9. Murray BM, Paller MS, Ferris TF. Effect of cyclosporine administration on renal hemodynamics in conscious rats. Kidney Int 1985; 28: 767.
10. Grieve EM, Hawksworth GM, Simpson JG, Whiting PH. The reversal of experimental cyclosporin A nephrotoxicity by thromboxane synthetase inhibition. Biochem Pharmacol 1993; 45: 1351.
11. Kon V, Hunley TE, Fogo A. Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis: studies in chronic cyclosporine nephrotoxicity in rats. Transplantation 1995; 60: 89.
12. Assis SM, Monteiro JL, Seguro AC. L-arginine and allopurinol protect against cyclosporine nephrotoxicity. Transplantation 1997; 63: 1070.
13. Mihatsch MJ, Ryffel B, Gudat F. The differential diagnosis between rejection and cyclosporine toxicity. Kidney Int 1995; 48 (suppl 52): S63.
14. Bennett WM, DeMattos A, Meyer MM, Andoh T, Barry JM. Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy. Kidney Int 1996; 50: 1089.
15. Bertani T, Ferazzi P, Schieppati A, et al. Nature and extent of glomerular injury induced by cyclosporine in heart transplant patients. Kidney Int 1991; 40: 243.
16. Ghiggeri GM, Altieri P, Oleggini R, et al. Cyclosporine enhances the synthesis of selected extracellular matrix proteins by renal cells in culture: different cell responses and phenotype characterization. Transplantation 1994; 57: 1382.
17. Young B, Burdmann EA, Johnson RJ, et al. Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity. Kidney Int 1995; 48: 439.
18. Burdmann EA, Andoh TF, Nast CC, et al. Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril. Am J Physiol 1995; 269: F491.
19. Wolf G, Thaiss F, Stahl RA. Cyclosporine stimulates expression of transforming growth factor-β in renal cells: possible mechanism of cyclosporines antiproliferative effects. Transplantation 1995; 60: 237.
20. Rosen S, Greenfeld Z, Brezis M. Chronic cyclosporine-induced nephropathy in the rat: a medullary ray and inner stripe injury. Transplantation 1990; 49: 445.
21. Elzinga LW, Rosen S, Bennett WM. Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy: role of sodium intake. J Am Soc Nephrol 1993; 4: 214.
22. Welch WJ, Deng X, Snellen H, Wilcox CS. Validation of miniature ultrasonic transit-time flow probes for measurement of renal blood flow in rats. Am J Physiol 1995; 268: F175.
23. Noronha IL, Eberlein-Gonska M, Hartley B, Stephens S, Cameron JS, Waldherr R. In situ expression of tumor necrosis factor-alpha, interferon-gamma and interleukin-2 receptors in renal allograft biopsies. Transplantation 1992; 54: 1017.
24. Gardner MP, Houghton DC, Andoh TF, Lindsley J, Bennett WM. Clinically relevant doses and blood levels produce experimental cyclosporine nephrotoxicity when combined with nitric oxid inhibition. Transplantation 1996; 61: 1506.
25. Benigni A, Bruzzi I, Mister M, et al. Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year. Kidney Int 1999; 55: 674.
26. Perico N, Ruggenenti P, Gaspari F, et al. Daily renal hypoperfusion induced by cyclosporine in patients with renal transplantation. Transplantation 1992; 54: 56.
27. Pichler RH, Franceschini N, Young BA, et al. Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin. J Am Soc Nephrol 1995; 6: 1186.
28. Giachelli CM, Pichler R, Lombardi D, et al. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 1994; 45: 515.
29. Thomas SE, Andoh TF, Pichler RH, et al. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 1998; 53: 897.
30. Border WA, Ruoslahti E. Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest 1992; 90: 1.
31. Prashar Y, Khanna A, Sehajpal P, Sharma VK, Suthanthiran M. Stimulation of transforming growth factor-β1 transcription by cyclosporine. FEBS Lett 1995; 358: 109.
32. Shin GT, Khanna A, Ding R, et al. In vivo expression of transforming growth factor-beta1 in humans: stimulation by cyclosporine. Transplantation 1998; 65: 313.
33. Kagami S, Border W, Miller D, Noble N. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 1994; 93: 2431.
34. Shihab FS, Bennett WM, Tanner AM, Andoh TF. Angiotensin II blockade decreases TGF-beta 1 and matrix proteins in cyclosporine nephropathy. Kidney Int 1997; 52: 660.
35. Lee DBN. Cyclosporine and the renin-angiotensin axis. Kidney Int 1997; 52: 248.
36. Tufro-McReddie A, Gomez RA, Norling LL, Omar AA, Moore LC, Kaskel FJ. Effect of CsA on the expression of renin and angiotensin type 1 receptor genes in the rat kidney. Kidney Int 1993; 43: 615.
37. del Moral RG, Andújar M, Ramírez C, et al. Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits. Am J Pathol 1997; 151: 1705.
38. Shehata M, Cope GH, Johnson TS, Raftery AT, El Nahas AM. Cyclosporine enhances the expression of TGF-β in the juxtaglomerular cells of the rat kidney. Kidney Int 1995; 48: 1487.
39. Horikoshi S, McCune BK, Ray PE, Kopp JB, Sporn MB, Klotman PE. Water deprivation stimulates transforming growth factor-β2 accumulation in the juxtaglomerular apparatus of mouse kidney. J Clin Invest 1990; 88: 2117.
40. Antonipillai I, Le TH, Soceneantu L, Horton R. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol 1993; 265: F537.
41. Liu A, Ballermann BJ. TGF-β type-2 receptor in rat renal vascular development: localization to juxtaglomerular cells. Kidney Int 1998; 53: 716.
42. Young B, Burdmann EA, Johnson RJ, et al. Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy. Kidney Int 1995; 48: 431.
43. Meister B, Lippoldt A, Bunnemann B, Inagami T, Ganten D, Fuxe K. Cellular expression of angiotensin type-1 receptor mRNA in the kidney. Kidney Int 1993; 44: 331.
44. Yagil Y. Acute effect of cyclosporin on inner medullary blood flow in normal and postischemic rat kidney. Am J Physiol 1990; 258: F1139.
45. Winston JA, Feingold R, Safirstein R. Glomerular hemodynamics in cyclosporine nephrotoxicity following uninephrectomy. Kidney Int 1989; 35: 1175.