Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)

Molecular Pain

Volumn 7, Issue , 2011, Pages

  Lee, Bolam ^a   Descalzi, Giannina ^b   Baek, Jinhee ^a   Kim, Jae Ick ^a   Lee, Hye Ryeon ^a   Lee, Kyungmin ^c   Kaang, Bong Kiun ^a   Zhuo, Min ^a,b  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF TORONTO   (Canada)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEINASE ACTIVATED RECEPTOR 2; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CHRONIC PAIN; CONTROLLED STUDY; FEMALE; GENE DELETION; LICKING; MALE; MECHANICAL STIMULATION; MOUSE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PRURITUS; SCRATCHING; STIMULUS RESPONSE; THERMAL STIMULATION; ANIMAL; ANIMAL BEHAVIOR; DRUG POTENTIATION; GENETIC ENHANCEMENT; GENETICS; METABOLISM; METHODOLOGY; MOUSE MUTANT;

ANIMALS; BEHAVIOR, ANIMAL; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; GENETIC ENHANCEMENT; HISTAMINE; MICE; MICE, KNOCKOUT; PRURITUS; RECEPTOR, PAR-2;

EID: 83355163989     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-7-96     Document Type: Article

References (31)

1. Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 2010, 11(5):329-341. 10.1038/nrm2882, 20379207.
2. Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7(8):606-619. 10.1038/nrg1879, 16847462.
3. Yang PC, Yang CH, Huang CC, Hsu KS. Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. J Biol Chem 2008, 283(5):2631-2643.
4. Gobert D, Topolnik L, Azzi M, Huang L, Badeaux F, Desgroseillers L, Sossin WS, Lacaille JC. Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. J Neurochem 2008, 106(3):1160-1174. 10.1111/j.1471-4159.2008.05470.x, 18466337.
5. Sanna PP, Cammalleri M, Berton F, Simpson C, Lutjens R, Bloom FE, Francesconi W. Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. J Neurosci 2002, 22(9):3359-3365.
6. Perkinton MS, Ip JK, Wood GL, Crossthwaite AJ, Williams RJ. Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. J Neurochem 2002, 80(2):239-254. 10.1046/j.0022-3042.2001.00699.x, 11902114.
7. Kim JI, Lee HR, Sim SE, Baek J, Yu NK, Choi JH, Ko HG, Lee YS, Park SW, Kwak C, et al. PI3Kgamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nature neuroscience 2011, 14(11):1447-1454. 10.1038/nn.2937, 22019731.
8. Ruckle T, Schwarz MK, Rommel C. PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?. Nat Rev Drug Discov 2006, 5(11):903-918. 10.1038/nrd2145, 17080027.
9. Zhu W, Oxford GS. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci 2007, 34(4):689-700. 10.1016/j.mcn.2007.01.005, 2699283, 17324588.
10. Xu JT, Tu HY, Xin WJ, Liu XG, Zhang GH, Zhai CH. Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. Exp Neurol 2007, 206(2):269-279. 10.1016/j.expneurol.2007.05.029, 17628541.
11. Konig C, Gavrilova-Ruch O, von Banchet GS, Bauer R, Grun M, Hirsch E, Rubio I, Schulz S, Heinemann SH, Schaible HG, et al. Modulation of mu opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase gamma. Neuroscience 2010, 169(1):449-454. 10.1016/j.neuroscience.2010.04.068, 20451587.
12. Bogen O, Joseph EK, Chen X, Levine JD. GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci 2008, 28(1):12-19. 10.1111/j.1460-9568.2008.06308.x, 2660608, 18616564.
13. Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev Neurosci 2006, 7(7):535-547. 10.1038/nrn1950, 16791143.
14. Jinks SL, Carstens E. Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine. J Neurophysiol 2000, 84(2):616-627.
15. Andrew D, Craig AD. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 2001, 4(1):72-77. 10.1038/82924, 11135647.
16. Nojima H, Simons CT, Cuellar JM, Carstens MI, Moore JA, Carstens E. Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin. J Neurosci 2003, 23(34):10784-10790.
17. Nojima H, Carstens E. 5-Hydroxytryptamine (5-HT)2 receptor involvement in acute 5-HT-evoked scratching but not in allergic pruritus induced by dinitrofluorobenzene in rats. J Pharmacol Exp Ther 2003, 306(1):245-252. 10.1124/jpet.103.049239, 12682216.
18. Akiyama T, Carstens MI, Carstens E. Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. J Neurophysiol 2009, 102(4):2176-2183. 10.1152/jn.00463.2009, 2776995, 19625538.
19. Koga K, Chen T, Li XY, Descalzi G, Ling J, Gu J, Zhuo M. Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Mol Pain 2011, 7(1):47. 10.1186/1744-8069-7-47, 3132725, 21699733.
20. Sun YG, Chen ZF. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007, 448(7154):700-703. 10.1038/nature06029, 17653196.
21. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994, 53(1):55-63. 10.1016/0165-0270(94)90144-9, 7990513.
22. Lagerstrom MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, et al. VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron 2010, 68(3):529-542. 10.1016/j.neuron.2010.09.016, 3052264, 21040852.
23. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci USA 2009, 106(27):11330-11335. 10.1073/pnas.0905605106, 2708751, 19564617.
24. Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, et al. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 2004, 24(18):4300-4312. 10.1523/JNEUROSCI.5679-03.2004, 15128844.
25. Zhuo M. Cortical excitation and chronic pain. Trends Neurosci 2008, 31(4):199-207. 10.1016/j.tins.2008.01.003, 18329111.
26. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000, 288(5472):1765-1769. 10.1126/science.288.5472.1765, 10846153.
27. Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 2010, 68(3):543-556. 10.1016/j.neuron.2010.09.008, 2991105, 21040853.
28. Cao X, Mercaldo V, Li P, Wu LJ, Zhuo M. Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex. Mol Pain 2010, 6:52. 10.1186/1744-8069-6-52, 2945970, 20836873.
29. Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, Liu L, D'Souza S, Wong TP, Taghibiglou C, Lu J, et al. Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron 2003, 38(4):611-624. 10.1016/S0896-6273(03)00228-9, 12765612.
30. Asrar S, Zhou Z, Ren W, Jia Z. Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II. PLoS One 2009, 4(2):e4339. 10.1371/journal.pone.0004339, 2629531, 19190753.
31. Cevikbas F, Steinhoff M, Ikoma A. Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development. CNS Neurosci Ther 2010,