15N relaxation NMR studies of prolyl oligopeptidase, an 80 kDa enzyme, reveal a pre-existing equilibrium between different conformational states

ChemBioChem

Volumn 12, Issue 18, 2011, Pages 2737-2739

  Kichik, Nessim ^a   Tarragó, Teresa ^a   Claasen, Birgit ^a   Gairí, Margarida ^c   Millet, Oscar ^b   Giralt, Ernest ^a,c  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b CIC BIOGUNE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Ligand recognition; NMR spectroscopy; Prolyl oligopeptidase; Protein dynamics; Proteins

Indexed keywords

NITROGEN 15; PROLYL ENDOPEPTIDASE; NITROGEN; SERINE PROTEINASE;

ARTICLE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TRANSVERSE RELAXATION OPTIMIZED SPECTROSCOPY; ANIMAL; CHEMISTRY; PROTEIN CONFORMATION; SWINE;

ANIMALS; MODELS, MOLECULAR; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SWINE;

EID: 83355160772     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201100614     Document Type: Article

References (14)

1. P. Bernadó, M. Blackledge, Nature 2010, 468, 1046-1048.
2. K. Henzler-Wildman, D. Kern, Nature 2007, 450, 964-972.
3. A. V. Smrcka, N. Kichik, T. Tarragó, M. Burroughs, M. Park, N. K. Itoga, H. A. Stern, B. M. Willardson, E. Giralt, Proc. Natl. Acad. Sci. USA 2010, 107, 639-644.
4. T. T. Myöhänen, J. A. García-Horsman, J. Tenorio-Laranga, P. T. Männistö, J. Histochem. Cytochem. 2009, 57, 831-848.
5. E. Di Daniel, C. P. Glover, E. Grot, T. H. Sanderson, J. H. White, C. L. Ellis, K. T. Gallagher, J. Uney, J. Thomas, P. R. Maycox, A. W. Mudge, Mol. Cell. Neurosci. 2009, 41, 373-382.
6. J. Lawandi, S. Gerber-Lemaire, L. Juillerat-Jeanneret, N. Moitessier, J. Med. Chem. 2010, 53, 3423-3438.
7. T. Tarragó, B. Claasen, N. Kichik, R. A. Rodríguez-Mias, M. Gairí, E. Giralt, ChemBioChem 2009, 10, 2736-2739.
8. V. Fülöp, Z. Böcskei, L. Polgár, Cell 1998, 94, 161-170.
9. C. Wang, A. G. Palmer III, Magn. Reson. Chem. 2003, 41, 866-876.
10. C. Wang, M. Rance, A. G. Palmer III, J. Am. Chem. Soc. 2003, 125, 8968-8969.
11. M. Li, C. Chen, D. R. Davies, T. K. Chiu, J. Biol. Chem. 2010, 285, 21487-21495.
12. V. Hartmat, K. Domokos, D. K. Menyhárd, A. Palló, Z. Szeltner, I. Szamosi, T. Beke-Somfai, G. Náray-Szabó, L. Polgár, J. Biol. Chem. 2010, 285, 1987-1998.
13. E. Z. Eisenmesser, O. Millet, W. Labeikovsky. D. M. Korzhnev, M. Wolf-Watz, D. A. Bosco, J. J. Skalicky, L. E. Kay, D. Kern, Nature 2005, 438, 117-121.
14. O. F. Lange, N. Lakomek, C. Farès, G. F. Schröder, K. F. A. Walter, S. Becker, J. Meiler, H. Grubmüller, C. Griesinger, B. L. De Groot, Science 2008, 320, 1471-1475.