Detection of cytochrome P450 substrates by using a small-molecule droplet array on an NADH-immobilized solid surface

ChemBioChem

Volumn 12, Issue 18, 2011, Pages 2748-2752

  Takayama, Hiroshi ^a   Takahashi, Shunji ^b   Moriya, Takashi ^a   Osada, Hiroyuki ^b   Iwabuchi, Yoshiharu ^a   Kanoh, Naoki ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b RIKEN   (Japan)

Author keywords

Cytochromes; Immobilization; Microarrays; Nicotinamide adenine dinucleotide; Substrate screening

Indexed keywords

ACETAMIDE; ACETOPHENONE; ACETOPHENONE DERIVATIVE; CAMPHOR; CARBOXYLIC ACID; CYTOCHROME P450; FERREDOXIN; FERROUS SULFATE; FORMIC ACID; NICOTINAMIDE DERIVATIVE; PYRIDINIUM DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINIC ACID; SUCCINIC ANHYDRIDE; TRIETHYLENE GLYCOL;

ARTICLE; BIOTINYLATION; ENZYME ANALYSIS; ENZYME CHEMISTRY; ENZYME ENGINEERING; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HIGH THROUGHPUT SCREENING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SMALL MOLECULE DROPLET ARRAY; SOLID; SPECTROFLUOROMETRY; SURFACE PROPERTY;

BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; NAD; SUBSTRATE SPECIFICITY; SURFACE PROPERTIES;

EID: 83355160742     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201100541     Document Type: Article

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