Cell-penetrating peptides as antifungals towards Malassezia sympodialis

Letters in Applied Microbiology

Volumn 54, Issue 1, 2012, Pages 39-44

  Holm, T ^a   Bruchmann, J ^a   Scheynius, A ^b   Langel, Ü ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antifungal; Antimicrobial peptide; Atopic eczema; Cell penetrating peptide; Dandruff; Host defence peptide; Malassezia sympodialis; Seborrhoeic eczema

Indexed keywords

ANTIFUNGAL AGENTS; CELLS; CYTOLOGY; DAMAGE DETECTION; MAMMALS; MICROORGANISMS; YEAST;

ANTIFUNGALS; ANTIMICROBIAL PEPTIDE; ATOPIC ECZEMA; CELL-PENETRATING PEPTIDE; DANDRUFF; HOST DEFENSE; HOST DEFENSE PEPTIDE; MALASSEZIA SYMPODIALIS; MAMMALIAN CELLS; SEBORRHOEIC ECZEMA;

PEPTIDES;

ARGININE 9; CELL PENETRATING PEPTIDE; FLATTFISH ANTIMICROBIAL PEPTIDE; HISTATIN5; MASTOPARAN; MASTOPARAN B; MELITTIN; PENETRATIN; PEPTIDE BMAP28; PEPTIDE CAMEL 102; PEPTIDE CAMEL 46; PEPTIDE ECATH 1; PEPTIDE TAT (47-57); PEPTIDE TP10; PISCIDIN 1; PISCIDIN 2; PISCIDIN 3; POLYPEPTIDE ANTIBIOTIC AGENT; PONERICIN W5; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; INHIBITOR; MEMBRANE; PEPTIDE; SKIN DISORDER; YEAST;

AMINO ACID SEQUENCE; ANTIFUNGAL ACTIVITY; ARTICLE; BROTH DILUTION; COLONY FORMING UNIT; FUNGUS GROWTH; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; ISOELECTRIC POINT; KERATINOCYTE; MALASSEZIA; MALASSEZIA SYMPODIALIS; MEMBRANE DAMAGE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN;

MALASSEZIA SYMPODIALIS; MAMMALIA;

EID: 83255193908     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2011.03168.x     Document Type: Article

References (32)

1. Arrighi, R.B., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L., Barrett, M.P., Langel, Ü. and Faye, I. (2008) Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrob Agents Chemother 52, 3414-3417.
2. Ashbee, R.H. and Scheynius, A. (2010) Malassezia. In Pathogenic Yeasts ed. Ashbee, R.H. and Bignell, E. pp. 209-230. Germany: Springer Verlag Heidelberg.
3. Asthana, N., Yadav, S.P. and Ghosh, J.K. (2004) Dissection of antibacterial and toxic activity of melittin: a leucine zipper motif plays a crucial role in determining its hemolytic activity but not antibacterial activity. J Biol Chem 279, 55042-55050.
4. Bieber, T. (2010) Atopic dermatitis. Ann Dermatol 22, 125-137.
5. Boman, H.G. (1995) Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 13, 61-92.
6. Eisenberg, D., Schwarz, E., Komaromy, M. and Wall, R. (1984) Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J Mol Biol 179, 125-142.
7. El Andaloussi, S., Holm, T. and Langel, Ü. (2005) Cell-penetrating peptides: mechanisms and applications. Curr Pharm Des 11, 3597-3611.
8. Gaitanis, G. and Mayser, P. (2010) Seborrheic eczema/dermatitis. In Malassezia and the Skin ed. Boekhout, T., Guého-Kellerman, E., Mayser, P. and Velegraki, A. pp. 202-212. New York: Springer Verlag Heidelberg.
9. Gueho, E., Midgley, G. and Guillot, J. (1996) The genus Malassezia with description of four new species. Antonie Van Leeuwenhoek 69, 337-355.
10. Heitz, F., Morris, M.C. and Divita, G. (2009) Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol 157, 195-206.
11. Helmerhorst, E.J., Reijnders, I.M., van't Hof, W., Simoons-Smit, I., Veerman, E.C. and Amerongen, A.V. (1999) Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. Antimicrob Agents Chemother 43, 702-704.
12. Holm, T., Netzereab, S., Hansen, M., Langel, Ü. and Hällbrink, M. (2005) Uptake of cell-penetrating peptides in yeasts. FEBS Lett 579, 5217-5222.
13. Johansson, H.J., El Andaloussi, S., Holm, T., Mäe, M., Jänes, J., Maimets, T. and Langel, Ü. (2008) Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein. Mol Ther 16, 115-123.
14. Jung, H.J., Park, Y., Hahm, K.S. and Lee, D.G. (2006) Biological activity of Tat (47-58) peptide on human pathogenic fungi. Biochem Biophys Res Commun 345, 222-228.
15. Jung, H.J., Jeong, K.S. and Lee, D.G. (2008) Effective antibacterial action of tat (47-58) by increased uptake into bacterial cells in the presence of trypsin. J Microbiol Biotechnol 18, 990-996.
16. Komatsu, T., Salih, E., Helmerhorst, E.J., Offner, G.D. and Oppenheim, F.G. (2011) Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res 10, 646-655.
17. Luque-Ortega, J.R., van't Hof, W., Veerman, E.C., Saugar, J.M. and Rivas, L. (2008) Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. FASEB J 22, 1817-1828.
18. Marcos, J.F. and Gandía, M. (2009) Antimicrobial peptides: to membranes and beyond. Expert Opin Drug Discov 4(6), 659-671.
19. Naldi, L. and Rebora, A. (2009) Clinical practice. Seborrheic dermatitis. N Engl J Med 360, 387-396.
20. Nekhotiaeva, N., Elmquist, A., Rajarao, G.K., Hällbrink, M., Langel, Ü. and Good, L. (2004) Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. FASEB J 18, 394-396.
21. Palm, C., Netzereab, S. and Hällbrink, M. (2006) Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobial effects. Peptides 27, 1710-1716.
22. Papo, N. and Shai, Y. (2003) Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes? Peptides 24, 1693-1703.
23. Pitman, S.K., Drew, R.H. and Perfect, J.R. (2011) Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations. Expert Opin Emerg Drugs 16, 559-586.
24. Ryu, S., Choi, S.Y., Acharya, S., Chun, Y.J., Gurley, C., Park, Y., Armstrong, C.A., Song, P.I. et al. (2011) Antimicrobial and Anti-Inflammatory Effects of Cecropin A(1-8)-Magainin2(1-12) Hybrid Peptide Analog P5 against Malassezia furfur Infection in Human Keratinocytes. J Invest Dermatol 131, 1677-1683.
25. Sandström Falk, M.H., Tengvall Linder, M., Johansson, C., Bartosik, J., Back, O., Särnhult, T., Wahlgren, C.F., Scheynius, A. et al. (2005) The prevalence of Malassezia yeasts in patients with atopic dermatitis, seborrhoeic dermatitis and healthy controls. Acta Derm Venereol 85, 17-23.
26. Scheynius, A. and Crameri, C. (2010) Malassezia in Atopic eczema/dermatitis. In Malassezia and the Skin ed. Boekhout, T., Guého-Kellerman, E., Mayser, P. and Velegraki, A. pp. 212-228. New York: Springer Verlag Heidelberg.
27. Sollenberg, U., Runesson, J., Sillard, R. and Langel, Ü. (2010) Binding of chimeric peptides M617 and M871 to galanin receptor Type 3 reveals characteristics of galanin receptor-ligand interaction. Int J Pept Res Ther 16, 17-22.
28. Takahashi, D., Shukla, S.K., Prakash, O. and Zhang, G. (2010) Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity. Biochimie 92, 1236-1241.
29. Wang, H., Xu, K., Liu, L., Tan, J.P., Chen, Y., Li, Y., Fan, W., Wei, Z. et al. (2010) The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis. Biomaterials 31, 2874-2881.
30. Xu, T., Levitz, S.M., Diamond, R.D. and Oppenheim, F.G. (1991) Anticandidal activity of major human salivary histatins. Infect Immun 59, 2549-2554.
31. Yu, K., Park, K., Kang, S.W., Shin, S.Y., Hahm, K.S. and Kim, Y. (2002) Solution structure of a cathelicidin-derived antimicrobial peptide, CRAMP as determined by NMR spectroscopy. J Pept Res 60, 1-9.
32. Zhu, W.L. and Shin, S.Y. (2009) Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action. J Pept Sci 15, 345-352.