Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction

International Journal of Peptide Research and Therapeutics

Volumn 16, Issue 1, 2010, Pages 17-22

  Sollenberg, Ulla E ^a   Runesson, Johan ^a   Sillard, Rannar ^a   Langel, Ülo ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Chimeric peptide; Galanin; Galanin receptor type 3; GalR3; GPCR

Indexed keywords

ALANINE; CHIMERIC PROTEIN; GALANIN RECEPTOR 1; GALANIN RECEPTOR 2; GALANIN RECEPTOR 3; M35 PEPTIDE; M40 PEPTIDE; M617 PEPTIDE; M871 PEPTIDE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOTHESIS; LIGAND BINDING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STIMULATION;

EID: 77950019615     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-009-9197-9     Document Type: Article

References (25)

1. KA Alier Y Chen UE Sollenberg U Langel PA Smith 2008 Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin Pain 137 138 146
2. T Bartfai Ü Langel K Bedecs S Andell T Land S Gregersen B Ahren P Girotti S Consolo R Corwin 1993 Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes Proc Natl Acad Sci USA 90 11287 11291
3. E Habert-Ortoli B Amiranoff I Loquet M Laburthe JF Mayaux 1994 Molecular cloning of a functional human galanin receptor Proc Natl Acad Sci USA 91 9780 9783
4. SA Hobson A Bacon CR Elliot-Hunt FE Holmes NC Kerr R Pope P Vanderplank D Wynick 2008 Galanin acts as a trophic factor to the central and peripheral nervous systems Cell Mol Life Sci 65 1806 1812
5. JM Jimenez-Andrade L Lundström UE Sollenberg Ü Langel G Castaneda-Hernandez SM Carlton 2006 Activation of peripheral galanin receptors: differential effects on nociception Pharmacol Biochem Behav 85 273 280
6. K Kask M Berthold J Bourne S Andell Ü Langel T Bartfai 1995 Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in rin m 5F insulinoma cells Regul Pept 59 341 348
7. LF Kolakowski Jr GP O'Neill AD Howard SR Broussard KA Sullivan SD Feighner M Sawzdargo T Nguyen S Kargman LL Shiao DL Hreniuk CP Tan J Evans M Abramovitz A Chateauneuf N Coulombe G Ng MP Johnson A Tharian H Khoshbouei SR George RG Smith BF O'Dowd 1998 Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 J Neurochem 71 6 2239 2251
8. E Kuteeva T Hökfelt T Wardi SO Ögren 2008 Galanin, galanin receptor subtypes and depression-like behaviour Cell Mol Life Sci 65 1854 1863
9. E Kuteeva T Wardi L Lundström U Sollenberg Ü Langel T Hökfelt SO Ögren 2008 Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level Neuropsychopharmacology 33 2573 2585
10. T Land Ü Langel M Low M Berthold A Undén T Bartfai 1991 Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor Int J Pept Protein Res 38 3 267 272
11. R Lang AL Gundlach B Kofler 2007 The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease Pharmacol Ther 115 177 207
12. SF Leibowitz 2005 Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis Neuropeptides 39 327 332
13. JT Lerner R Sankar AM Mazarati 2008 Galanin and epilepsy Cell Mol Life Sci 65 1864 1871
14. HX Liu T Hökfelt 2002 The participation of galanin in pain processing at the spinal level Trends Pharmacol Sci 23 468 474
15. HX Liu P Brumovsky R Schmidt W Brown K Payza L Hodzic C Pou C Godbout T Hökfelt 2001 Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors Proc Natl Acad Sci USA 98 9960 9964
16. X Lu L Lundström T Bartfai 2005 Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes Neuropeptides 39 165 167
17. X Lu L Lundström Ü Langel T Bartfai 2005 Galanin receptor ligands Neuropeptides 39 143 146
18. L Lundström U Sollenberg A Brewer PF Kouya K Zheng X-J Xu X Sheng JK Robinson Z Wiesenfeld-Hallin Z-Q Xu T Hökfelt T Bartfai Ü Langel 2005 A galanin receptor subtype 1 specific agonist Int J Pep Res Ther 11 17 27
19. A Mazarati L Lundström U Sollenberg D Shin Ü Langel R Sankar 2006 Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling J Pharmacol Exp Ther 318 700 708
20. JK Robinson 2004 Galanin and cognition Behav Cogn Neurosci Rev 3 222 242
21. J Runesson I Saar L Lundström J Järv Ü Langel 2009 A novel GalR2-specific peptide agonist Neuropeptides 43 3 187 192
22. KE Smith MW Walker R Artymyshyn J Bard B Borowsky JA Tamm WJ Yao PJ Vaysse TA Branchek C Gerald KA Jones 1998 Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels J Biol Chem 273 23321 23326
23. UE Sollenberg L Lundström T Bartfai Ü Langel 2006 M871-A novel peptide antagonist selectively recognizing the galanin receptor type 2 Int J Pep Res Ther 12 115 119
24. S Wang T Hashemi C He C Strader M Bayne 1997 Molecular cloning and pharmacological characterization of a new galanin receptor subtype Mol Pharmacol 52 337 343
25. S Wang T Hashemi S Fried AL Clemmons BE Hawes 1998 Differential G-protein-coupling profiles of the GalR1 and GalR2 galanin receptors Biochemistry 37 6711 6717