Comparative analysis of various prognostic nodal factors, adjuvant chemotherapy and survival among stage III colon cancer patients over 65 years: An analysis using Surveillance, Epidemiology and End Results (SEER)-Medicare data

Colorectal Disease

Volumn 14, Issue 1, 2012, Pages 48-55

  Hanna, N N ^a   Onukwugha, E ^b   Choti, M A ^c   Davidoff, A J ^b   Zuckerman, I H ^b   Hsu, V D ^b   Mullins, C D ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Chemotherapy; Colon cancer; Node ratio; Positive nodes; Survival

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER REGISTRY; CANCER STAGING; CANCER SURVIVAL; COLON CANCER; COLON RESECTION; COMPARATIVE STUDY; FEMALE; HUMAN; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MEDICARE; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL SIGNIFICANCE;

AGED; AGED, 80 AND OVER; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MEDICARE; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SEER PROGRAM; SURVIVAL ANALYSIS; UNITED STATES;

EID: 83255187968     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2011.02545.x     Document Type: Article

References (29)

1. NCI. Cancer of the Colon and Rectum. SEER Stat Fact Sheets. 2008.
2. Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 2007; 99: 433-441.
3. NCI. Colon Cancer Treatment. 2008.
4. George S, Primrose J, Talbot R et al. Will Rogers revisited: prospective observational study of survival of 3592 patients with colorectal cancer according to number of nodes examined by pathologists. Br J Cancer 2006; 95: 841-847.
5. Le Voyer TE, Sigurdson ER, Hanlon AL et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol 2003; 21: 2912-2919.
6. Lemmens VE, van Lijnschoten I, Janssen-Heijnen ML, Rutten HJ, Verheij CD, Coebergh JW. Pathology practice patterns affect lymph node evaluation and outcome of colon cancer: a population-based study. Ann Oncol 2006; 17: 1803-1809.
7. Prandi M, Lionetto R, Bini A et al. Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial. Ann Surg 2002; 235: 458-463.
8. McGory ML, Zingmond DS, Sekeris E, Bastani R, Ko CY. A patient's race/ethnicity does not explain the underuse of appropriate adjuvant therapy in colorectal cancer. Dis Colon Rectum 2006; 49: 319-329.
9. Jensen SA, Vilmar A, Sorensen JB. Adjuvant chemotherapy in elderly patients (>or=75 yr) completely resected for colon cancer stage III compared to younger patients: toxicity and prognosis. Med Oncol 2006; 23: 521-531.
10. Gross CP, McAvay GJ, Guo Z, Tinetti ME. The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer. Cancer 2007; 109: 2410-2419.
11. Neugut AI, Matasar M, Wang X et al. Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol 2006; 24: 2368-2375.
12. AJCC AJCoC. Manual for Staging of Cancer. Third ed: American Joint Committee on Cancer; 1988.
13. Wang J, Hassett JM, Dayton MT, Kulaylat MN. Lymph node ratio: role in the staging of node-positive colon cancer. Ann Surg Oncol 2008; 15: 1600-1608.
14. Lee HY, Choi HJ, Park KJ et al. Prognostic significance of metastatic lymph node ratio in node-positive colon carcinoma. Ann Surg Oncol 2007; 14: 1712-1717.
15. Prentice RL, Gloeckler LA. Regression analysis of grouped survival data with application to breast cancer data. Biometrics. 1978; 34: 57-67.
16. Nieto FJ, Coresh J. Adjusting survival curves for confounders: a review and a new method. Am J Epidemiol 1996; 143: 1059-1068.
17. Zhang X, Loberiza FR, Klein JP, Zhang MJ. A SAS macro for estimation of direct adjusted survival curves based on a stratified Cox regression model. Comput Methods Programs Biomed 2007; 88: 95-101.
18. Arkenau HT, Bermann A, Rettig K, Strohmeyer G, Porschen R. 5-Fluorouracil plus leucovorin is an effective adjuvant chemotherapy in curatively resected stage III colon cancer: long-term follow-up results of the adjCCA-01 trial. Ann Oncol 2003; 14: 395-399.
19. Benson AB 3rd. Adjuvant chemotherapy of stage III colon cancer. Semin Oncol 2005; 6(Suppl 9): S74-77.
20. Fata F, Mirza A, Craig G et al. Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: a 10-year experience of the Geisinger Medical Center. Cancer 2002; 94: 1931-1938.
21. Gill S, Loprinzi CL, Sargent DJ et al. Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol 2004; 22: 1797-1806.
22. Jessup JM, Stewart A, Greene FL, Minsky BD. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. JAMA 2005; 294: 2703-2711.
23. Lemmens VE, van Halteren AH, Janssen-Heijnen ML, Vreugdenhil G, Repelaer van Driel OJ, Coebergh JW. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol 2005; 16: 767-772.
24. Porschen R, Bermann A, Loffler T et al. Fluorouracil plus leucovorin as effective adjuvant chemotherapy in curatively resected stage III colon cancer: results of the trial adjCCA-01. J Clin Oncol 2001; 19: 1787-1794.
25. Saltz LB, Niedzwiecki D, Hollis D et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. J Clin Oncol 2007; 25: 3456-3461.
26. Sargent DJ, Goldberg RM, Jacobson SD et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-1097.
27. Sundararajan V, Mitra N, Jacobson JS, Grann VR, Heitjan DF, Neugut AI. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med 2002; 136: 349-357.
28. NCCN. Colon cancer - v.4.2008. Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network. 2008.
29. Yu JB, Gross CP, Wilson LD, Smith BD. Public-use data from NCI-SEER: Applications and limitations in oncology research. Oncology. 2009; 23: 288-295.