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Volumn 90, Issue 2, 2012, Pages 518-528

Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain

Author keywords

5 HT; 5 hydroxytryptamine; MDMA; PDE5 inhibitor; Preconditioning; Serotonin; Sildenafil

Indexed keywords

3 NITROTYROSINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; BETA ACTIN; ETHIDIUM; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SEROTONIN; SEROTONIN TRANSPORTER; SILDENAFIL;

EID: 83155192220     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22759     Document Type: Article
Times cited : (10)

References (65)
  • 1
    • 33845933757 scopus 로고    scopus 로고
    • Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
    • Abdul HM, Butterfield DA. 2007. Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. Free Radic Biol Med 42: 371-384.
    • (2007) Free Radic Biol Med , vol.42 , pp. 371-384
    • Abdul, H.M.1    Butterfield, D.A.2
  • 2
    • 0037428498 scopus 로고    scopus 로고
    • Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis
    • Andoh T, Chiueh CC, Chock PB. 2003. Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis. J Biol Chem 278: 885-890.
    • (2003) J Biol Chem , vol.278 , pp. 885-890
    • Andoh, T.1    Chiueh, C.C.2    Chock, P.B.3
  • 3
    • 3142683642 scopus 로고    scopus 로고
    • The protective effect of hypoxic preconditioning on cortical neuronal cultures is associated with increases in the activity of several antioxidant enzymes
    • Arthur PG, Lim SC, Meloni BP, Munns SE, Chan A, Knuckey NW. 2004. The protective effect of hypoxic preconditioning on cortical neuronal cultures is associated with increases in the activity of several antioxidant enzymes. Brain Res 1017: 146-154.
    • (2004) Brain Res , vol.1017 , pp. 146-154
    • Arthur, P.G.1    Lim, S.C.2    Meloni, B.P.3    Munns, S.E.4    Chan, A.5    Knuckey, N.W.6
  • 4
    • 67849133763 scopus 로고    scopus 로고
    • Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain
    • Bhide NS, Lipton JW, Cunningham JI, Yamamoto BK, Gudelsky GA. 2009. Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain. Brain Res 1286: 32-41.
    • (2009) Brain Res , vol.1286 , pp. 32-41
    • Bhide, N.S.1    Lipton, J.W.2    Cunningham, J.I.3    Yamamoto, B.K.4    Gudelsky, G.A.5
  • 5
    • 75149150916 scopus 로고    scopus 로고
    • Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity
    • Biezonski DK, Meyer JS. 2010. Effects of 3, 4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. J Neurochem 112: 951-962.
    • (2010) J Neurochem , vol.112 , pp. 951-962
    • Biezonski, D.K.1    Meyer, J.S.2
  • 6
    • 33845670737 scopus 로고    scopus 로고
    • Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB
    • Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña J. 2006. Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB. FASEB J 20: 2136-2138.
    • (2006) FASEB J , vol.20 , pp. 2136-2138
    • Borrás, C.1    Gambini, J.2    Gómez-Cabrera, M.C.3    Sastre, J.4    Pallardó, F.V.5    Mann, G.E.6    Viña, J.7
  • 8
    • 22044455180 scopus 로고    scopus 로고
    • Induction of thioredoxin and mitochondrial survival proteins mediates preconditioning-induced cardioprotection and neuroprotection
    • Chiueh CC, Andoh T, Chock PB. 2005a. Induction of thioredoxin and mitochondrial survival proteins mediates preconditioning-induced cardioprotection and neuroprotection. Ann N Y Acad Sci 1042: 403-418.
    • (2005) Ann N Y Acad Sci , vol.1042 , pp. 403-418
    • Chiueh, C.C.1    Andoh, T.2    Chock, P.B.3
  • 9
    • 24644453212 scopus 로고    scopus 로고
    • Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin
    • Chiueh CC, Andoh T, Chock PB. 2005b. Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin. Toxicol Appl Pharmacol 207( Suppl): 96-102.
    • (2005) Toxicol Appl Pharmacol , vol.207 , Issue.SUPPL. , pp. 96-102
    • Chiueh, C.C.1    Andoh, T.2    Chock, P.B.3
  • 10
    • 0030986255 scopus 로고    scopus 로고
    • In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA (ecstasy) and p-choroamphetamine but not the degeneration following fenfluramine
    • Colado MI, O'shea E, Granados R, Murray TK, Green AR. 1997. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA (ecstasy) and p-choroamphetamine but not the degeneration following fenfluramine. Br J Pharmacol 121: 889-900.
    • (1997) Br J Pharmacol , vol.121 , pp. 889-900
    • Colado, M.I.1    O'shea, E.2    Granados, R.3    Murray, T.K.4    Green, A.R.5
  • 11
    • 0033553509 scopus 로고    scopus 로고
    • Cyclic GMP phosphodiesterase-5: target of sildenafil
    • Corbin JD, Francis SH. 1999. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem 274: 13729-13732.
    • (1999) J Biol Chem , vol.274 , pp. 13729-13732
    • Corbin, J.D.1    Francis, S.H.2
  • 13
    • 13244259290 scopus 로고    scopus 로고
    • Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain
    • Darvesh AS, Yamamoto BK, Gudelsky GA. 2005. Evidence for the involvement of nitric oxide in 3, 4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. J Pharmacol Exp Ther 312: 694-701.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 694-701
    • Darvesh, A.S.1    Yamamoto, B.K.2    Gudelsky, G.A.3
  • 14
    • 1542514717 scopus 로고    scopus 로고
    • Thioredoxin regulation of ischemic preconditioning
    • Das DK. 2004. Thioredoxin regulation of ischemic preconditioning. Antioxid Redox Signal 6: 405-412.
    • (2004) Antioxid Redox Signal , vol.6 , pp. 405-412
    • Das, D.K.1
  • 17
    • 33746818823 scopus 로고    scopus 로고
    • Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/malonate combination: implications for serotonin/dopamine interactions
    • Goñi-Allo B, Ramos M, Hervias I, Lasheras B, Aguirre N. 2006. Studies on striatal neurotoxicity caused by the 3, 4-methylenedioxymethamphetamine/malonate combination: implications for serotonin/dopamine interactions. J Psychopharmacol 20: 245-256.
    • (2006) J Psychopharmacol , vol.20 , pp. 245-256
    • Goñi-Allo, B.1    Ramos, M.2    Hervias, I.3    Lasheras, B.4    Aguirre, N.5
  • 18
    • 34147122755 scopus 로고    scopus 로고
    • Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats
    • Goñi-Allo B, Puerta E, Hervias I, Di Palma R, Ramos M, Lasheras B, Aguirre N. 2007. Studies on the mechanisms underlying amiloride enhancement of 3, 4-methylenedioxymethamphetamine-induced serotonin depletion in rats. Eur J Pharmacol 562: 198-207.
    • (2007) Eur J Pharmacol , vol.562 , pp. 198-207
    • Goñi-Allo, B.1    Puerta, E.2    Hervias, I.3    Di Palma, R.4    Ramos, M.5    Lasheras, B.6    Aguirre, N.7
  • 19
    • 40949119918 scopus 로고    scopus 로고
    • The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity
    • Goñi-Allo B, O'mathùna B, Segura M, Puerta E, Lasheras B, de la Torre R, Aguirre N. 2008a. The relationship between core body temperature and 3, 4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity. Psychopharmacology 197: 263-278.
    • (2008) Psychopharmacology , vol.197 , pp. 263-278
    • Goñi-Allo, B.1    O'mathùna, B.2    Segura, M.3    Puerta, E.4    Lasheras, B.5    de la Torre, R.6    Aguirre, N.7
  • 20
    • 40849129898 scopus 로고    scopus 로고
    • On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats
    • Goñi-Allo B, Puerta E, O'Mathúna B, Hervias I, Lasheras B, de la Torre R, Aguirre N. 2008b. On the role of tyrosine and peripheral metabolism in 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. Neuropharmacology 54: 885-900.
    • (2008) Neuropharmacology , vol.54 , pp. 885-900
    • Goñi-Allo, B.1    Puerta, E.2    O'Mathúna, B.3    Hervias, I.4    Lasheras, B.5    de la Torre, R.6    Aguirre, N.7
  • 21
    • 38449090057 scopus 로고    scopus 로고
    • Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK
    • Goñi-Allo B, Puerta E, Ramos M, Lasheras B, Jordan J, Aguirre N. 2008c. Minoxidil prevents 3, 4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK. J Neurochem 104: 914-925.
    • (2008) J Neurochem , vol.104 , pp. 914-925
    • Goñi-Allo, B.1    Puerta, E.2    Ramos, M.3    Lasheras, B.4    Jordan, J.5    Aguirre, N.6
  • 23
    • 0033564773 scopus 로고    scopus 로고
    • Altered serotonin innervation patterns in the forebrain of monkeys with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery
    • Hatzdimitrou G, Mccann UD, Ricaurte GA. 1999. Altered serotonin innervation patterns in the forebrain of monkeys with (+/-)3, 4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 19: 5096-5107.
    • (1999) J Neurosci , vol.19 , pp. 5096-5107
    • Hatzdimitrou, G.1    Mccann, U.D.2    Ricaurte, G.A.3
  • 24
    • 0033845013 scopus 로고    scopus 로고
    • 2-Deoxy-D-glugose prevents and nicotinamide potentiates 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity
    • Hervias I, Lasheras B, Aguirre N. 2000. 2-Deoxy-D-glugose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity. J Neurochem 75: 982-990.
    • (2000) J Neurochem , vol.75 , pp. 982-990
    • Hervias, I.1    Lasheras, B.2    Aguirre, N.3
  • 25
    • 3342877609 scopus 로고    scopus 로고
    • Nitric oxide and cerebral ischemic preconditioning
    • Huang PL. 2004. Nitric oxide and cerebral ischemic preconditioning. Cell Calcium 36: 323-329.
    • (2004) Cell Calcium , vol.36 , pp. 323-329
    • Huang, P.L.1
  • 26
    • 0029039754 scopus 로고
    • Peroxynitrite-mediated oxidative protein modifications
    • Ischiropoulos H, al-Mehdi AB. 1995. Peroxynitrite-mediated oxidative protein modifications. FEBS Lett 364: 279-282.
    • (1995) FEBS Lett , vol.364 , pp. 279-282
    • Ischiropoulos, H.1    al-Mehdi, A.B.2
  • 27
    • 1842562380 scopus 로고    scopus 로고
    • Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling
    • Jones NM, Bergeron M. 2004. Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling. J Neurochem 89: 157-167.
    • (2004) J Neurochem , vol.89 , pp. 157-167
    • Jones, N.M.1    Bergeron, M.2
  • 28
    • 0036304614 scopus 로고    scopus 로고
    • Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid
    • Kim GW, Chan PH. 2002. Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab 22: 798-809.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 798-809
    • Kim, G.W.1    Chan, P.H.2
  • 31
    • 33847694981 scopus 로고    scopus 로고
    • Single dose of MDMA causes extensive decrement of serotoninergic fiber density without blockage of the fast axonal transport in dark agouti rat brain and spinal cord
    • Kovács GG, Andó RD, Ádori C, Kirilly E, Benedek A, Palkovits M, Bagdy G. 2007. Single dose of MDMA causes extensive decrement of serotoninergic fiber density without blockage of the fast axonal transport in dark agouti rat brain and spinal cord. Neuropathol Appl Neurobiol 33: 193-203.
    • (2007) Neuropathol Appl Neurobiol , vol.33 , pp. 193-203
    • Kovács, G.G.1    Andó, R.D.2    Ádori, C.3    Kirilly, E.4    Benedek, A.5    Palkovits, M.6    Bagdy, G.7
  • 32
    • 0037646999 scopus 로고    scopus 로고
    • 17Beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection
    • Lee SY, Andoh T, Murphy DL, Chiueh CC. 2003. 17Beta-estradiol activates ICI 182, 780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J 17: 947-948.
    • (2003) FASEB J , vol.17 , pp. 947-948
    • Lee, S.Y.1    Andoh, T.2    Murphy, D.L.3    Chiueh, C.C.4
  • 33
    • 77952951645 scopus 로고    scopus 로고
    • ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells
    • Li Z, Shi K, Guan L, Cao T, Jiang Q, Yang Y, Xu C. 2010. ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells. FEBS Lett 584: 2291-2297.
    • (2010) FEBS Lett , vol.584 , pp. 2291-2297
    • Li, Z.1    Shi, K.2    Guan, L.3    Cao, T.4    Jiang, Q.5    Yang, Y.6    Xu, C.7
  • 34
    • 33645809775 scopus 로고    scopus 로고
    • Methamphetamine and sildenafil (Viagra) use are linked to unprotected receptive and insertive anal sex, respectively, in a sample of men who have sex with men
    • Mansergh G, Shouse RL, Marks G, Guzman R, Rader M, Buchbinder S, Colfax GN. 2006. Methamphetamine and sildenafil (Viagra) use are linked to unprotected receptive and insertive anal sex, respectively, in a sample of men who have sex with men. Sex Transm Infect 82: 131-134.
    • (2006) Sex Transm Infect , vol.82 , pp. 131-134
    • Mansergh, G.1    Shouse, R.L.2    Marks, G.3    Guzman, R.4    Rader, M.5    Buchbinder, S.6    Colfax, G.N.7
  • 35
    • 0033989637 scopus 로고    scopus 로고
    • Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users
    • Mccann UD, Eligulashvili V, Mertl M, Murphy DL, Ricaurte GA. 1999. Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3, 4-methylenedioxymethamphetamine (MDMA) users. Psychopharmacology 147: 56-65.
    • (1999) Psychopharmacology , vol.147 , pp. 56-65
    • Mccann, U.D.1    Eligulashvili, V.2    Mertl, M.3    Murphy, D.L.4    Ricaurte, G.A.5
  • 37
    • 51849123181 scopus 로고    scopus 로고
    • Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance
    • Mccann UD, Szabo Z, Vranesic M, Palermo M, Mathews WB, Ravert HT, Dannals RF, Ricaurte GA. 2008. Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3, 4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance. Psychopharmacology 200: 439-450.
    • (2008) Psychopharmacology , vol.200 , pp. 439-450
    • Mccann, U.D.1    Szabo, Z.2    Vranesic, M.3    Palermo, M.4    Mathews, W.B.5    Ravert, H.T.6    Dannals, R.F.7    Ricaurte, G.A.8
  • 38
    • 56049103760 scopus 로고    scopus 로고
    • Oral phosphodiesterase type 5 inhibitors: nonerectogenic beneficial uses
    • Mostafa T. 2008. Oral phosphodiesterase type 5 inhibitors: nonerectogenic beneficial uses. J Sex Med 5: 2502-2518.
    • (2008) J Sex Med , vol.5 , pp. 2502-2518
    • Mostafa, T.1
  • 39
    • 2542483507 scopus 로고    scopus 로고
    • Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation
    • Nagy K, Kis B, Rajapakse NC, Bari F, Busija DW. 2004. Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation. J Neurosci Res 76: 697-704.
    • (2004) J Neurosci Res , vol.76 , pp. 697-704
    • Nagy, K.1    Kis, B.2    Rajapakse, N.C.3    Bari, F.4    Busija, D.W.5
  • 40
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity
    • O'Hearn E, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME. 1988. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8: 2788-2803.
    • (1988) J Neurosci , vol.8 , pp. 2788-2803
    • O'Hearn, E.1    Battaglia, G.2    De Souza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 41
    • 84865436936 scopus 로고    scopus 로고
    • Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model
    • May 3 E-pub ahead of print
    • Orejana L, Barros-Miñones L, Jordán J, Puerta E, Aguirre N. 2011. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiol Aging [May 3 E-pub ahead of print
    • (2011) Neurobiol Aging
    • Orejana, L.1    Barros-Miñones, L.2    Jordán, J.3    Puerta, E.4    Aguirre, N.5
  • 43
    • 0343907202 scopus 로고    scopus 로고
    • Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia
    • Perez-Pinzon MA, Xu GP, Dietrich WD, Rosenthal M, Sick TJ. 1997. Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia. J Cereb Blood Flow Metab 17: 175-182.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 175-182
    • Perez-Pinzon, M.A.1    Xu, G.P.2    Dietrich, W.D.3    Rosenthal, M.4    Sick, T.J.5
  • 44
    • 57649219163 scopus 로고    scopus 로고
    • Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy
    • Pignataro G, Scorziello A, Di Renzo G, Annunziato L. 2009. Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy. FEBS J 276: 46-57.
    • (2009) FEBS J , vol.276 , pp. 46-57
    • Pignataro, G.1    Scorziello, A.2    Di Renzo, G.3    Annunziato, L.4
  • 45
    • 33645887834 scopus 로고    scopus 로고
    • Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist
    • Piper BJ, Vu HL, Safain MG, Oliver AJ, Meyer JS. 2006. Repeated adolescent 3, 4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist. J Pharmacol Exp Ther 317: 838-849.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 838-849
    • Piper, B.J.1    Vu, H.L.2    Safain, M.G.3    Oliver, A.J.4    Meyer, J.S.5
  • 46
    • 77952899690 scopus 로고    scopus 로고
    • Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats
    • Piper BJ, Ali SF, Daniels LG, Meyer JS. 2010. Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse 64: 421-431.
    • (2010) Synapse , vol.64 , pp. 421-431
    • Piper, B.J.1    Ali, S.F.2    Daniels, L.G.3    Meyer, J.S.4
  • 47
    • 70449485053 scopus 로고    scopus 로고
    • On the mechanisms underlying 3,4-methylenedioxymethamphetamine toxicity: the dilemma of the chicken and the egg
    • Puerta E, Hervias I, Aguirre N. 2009a. On the mechanisms underlying 3, 4-methylenedioxymethamphetamine toxicity: the dilemma of the chicken and the egg. Neuropsychobiology 60: 119-129.
    • (2009) Neuropsychobiology , vol.60 , pp. 119-129
    • Puerta, E.1    Hervias, I.2    Aguirre, N.3
  • 48
    • 58149357087 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat
    • Puerta E, Hervias I, Goñi-Allo B, Lasheras B, Jordán J, Aguirre N. 2009b. Phosphodiesterase 5 inhibitors prevent 3, 4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat. J Neurochem 108: 755-766.
    • (2009) J Neurochem , vol.108 , pp. 755-766
    • Puerta, E.1    Hervias, I.2    Goñi-Allo, B.3    Lasheras, B.4    Jordán, J.5    Aguirre, N.6
  • 50
    • 77951679086 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity
    • Puerta E, Hervias I, Goñi-Allo B, Zhang SF, Jordán J, Starkov AA, Aguirre N. 2010b. Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity. Br J Pharmacol 160: 233-245.
    • (2010) Br J Pharmacol , vol.160 , pp. 233-245
    • Puerta, E.1    Hervias, I.2    Goñi-Allo, B.3    Zhang, S.F.4    Jordán, J.5    Starkov, A.A.6    Aguirre, N.7
  • 52
    • 33750593772 scopus 로고    scopus 로고
    • Cardioprotection with sildenafil: implications for clinical practice
    • Raja SG. 2006. Cardioprotection with sildenafil: implications for clinical practice. Curr Med Chem 13: 3155-3164.
    • (2006) Curr Med Chem , vol.13 , pp. 3155-3164
    • Raja, S.G.1
  • 53
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N. 2008. Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 54
    • 0023797477 scopus 로고
    • 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates
    • Ricaurte GA, DeLanney LE, Wiener SG, Irwin I, Langston JW. 1988. 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3, 4-methylenedioxymethamphetamine in CNS of non-human primates. Brain Res 474: 359-363.
    • (1988) Brain Res , vol.474 , pp. 359-363
    • Ricaurte, G.A.1    DeLanney, L.E.2    Wiener, S.G.3    Irwin, I.4    Langston, J.W.5
  • 55
    • 0037233025 scopus 로고    scopus 로고
    • Signaling through NO and cGMP-dependent protein kinases
    • Schlossmann J, Feil R, Hofmann F. 2003. Signaling through NO and cGMP-dependent protein kinases. Ann Med 35: 21-27.
    • (2003) Ann Med , vol.35 , pp. 21-27
    • Schlossmann, J.1    Feil, R.2    Hofmann, F.3
  • 57
    • 0033028971 scopus 로고    scopus 로고
    • Activation of the extracellular signal-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning
    • Shamloo M, Rytter A, Wieloch T. 1999. Activation of the extracellular signal-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning. Neuroscience 93: 81-88.
    • (1999) Neuroscience , vol.93 , pp. 81-88
    • Shamloo, M.1    Rytter, A.2    Wieloch, T.3
  • 58
    • 0032763755 scopus 로고    scopus 로고
    • Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine
    • Shankaran M, Yamamoto BK, Gudelsky GA. 1999. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3, 4-methylenedioxymethamphetamine. Eur J Pharmacol 385: 103-110.
    • (1999) Eur J Pharmacol , vol.385 , pp. 103-110
    • Shankaran, M.1    Yamamoto, B.K.2    Gudelsky, G.A.3
  • 59
    • 0035123882 scopus 로고    scopus 로고
    • Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT
    • Shankaran M, Yamamoto BK, Gudelsky GA. 2001. Ascorbic acid prevents 3, 4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT. Synapse 40: 55-64.
    • (2001) Synapse , vol.40 , pp. 55-64
    • Shankaran, M.1    Yamamoto, B.K.2    Gudelsky, G.A.3
  • 60
    • 22244447089 scopus 로고    scopus 로고
    • Recreational use and misuse of phosphodiesterase 5 inhibitors
    • Smith KM, Romanelli F. 2005. Recreational use and misuse of phosphodiesterase 5 inhibitors. J Am Pharm Assoc 45: 63-72.
    • (2005) J Am Pharm Assoc , vol.45 , pp. 63-72
    • Smith, K.M.1    Romanelli, F.2
  • 61
    • 0029078456 scopus 로고
    • The monoamine oxidase-B inhibitor l-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits
    • Sprague J, Nichols DE. 1995. The monoamine oxidase-B inhibitor l-deprenyl protects against 3, 4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J Pharmacol Exp Ther 273: 667-673.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 667-673
    • Sprague, J.1    Nichols, D.E.2
  • 63
    • 0038507050 scopus 로고    scopus 로고
    • Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress
    • Teshima Y, Akao M, Li RA, Chong TH, Baumgartner WA, Johnston MV, Marban E. 2003. Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke 34: 1796-1802.
    • (2003) Stroke , vol.34 , pp. 1796-1802
    • Teshima, Y.1    Akao, M.2    Li, R.A.3    Chong, T.H.4    Baumgartner, W.A.5    Johnston, M.V.6    Marban, E.7
  • 64
    • 33748521847 scopus 로고    scopus 로고
    • Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor
    • Vidavalur R, Penumathsa SV, Zhan L, Thirunavukkarasu M, Maulik N. 2006. Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor. Vasc Pharmacol 45: 91-95.
    • (2006) Vasc Pharmacol , vol.45 , pp. 91-95
    • Vidavalur, R.1    Penumathsa, S.V.2    Zhan, L.3    Thirunavukkarasu, M.4    Maulik, N.5
  • 65
    • 67649472406 scopus 로고    scopus 로고
    • Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia
    • Zeynalov E, Shah ZA, Li RC, Doré S. 2009. Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia. Neurobiol Dis 35: 264-269.
    • (2009) Neurobiol Dis , vol.35 , pp. 264-269
    • Zeynalov, E.1    Shah, Z.A.2    Li, R.C.3    Doré, S.4


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