메뉴 건너뛰기




Volumn 45, Issue 12, 2011, Pages 1551-1558

Phosphodiesterase Type 5 Inhibitors as Adjunctive Therapy in the Management of Systolic Heart Failure;Inhibidores de la Fosfodiesterasa tipo 5 Como Tratamiento Adjunto en el Manejo de Fallo Cardiaco Sistólico

Author keywords

Exercise; Heart failure; Phosphodiesterase 5 inhibitor; Sildenafil; Tadalafil; Vardenafil

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SILDENAFIL; SPIRONOLACTONE; TADALAFIL; VARDENAFIL;

EID: 83155182933     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1Q421     Document Type: Review
Times cited : (16)

References (28)
  • 1
    • 65549145093 scopus 로고    scopus 로고
    • 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation
    • Hunt SA, Abraham WT, Chin MH, et al. 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009;119:e391-479.
    • (2009) Circulation , vol.119
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3
  • 2
    • 77953593318 scopus 로고    scopus 로고
    • HFSA 2010 comprehensive heart failure practice guideline
    • Heart Failure Society of America
    • Heart Failure Society of America, Lindenfeld J, Albert NM, et al. HFSA 2010 comprehensive heart failure practice guideline. J Card Fail 2010;16:e1-194.
    • (2010) J Card Fail , vol.16
    • Lindenfeld, J.1    Albert, N.M.2
  • 3
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2011 update: A report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 2011;123:e18-209.
    • (2011) Circulation , vol.123
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 4
    • 0030746480 scopus 로고    scopus 로고
    • Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults
    • Rich MW. Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults. J Am Geriatr Soc 1997;45:968-74.
    • (1997) J Am Geriatr Soc , vol.45 , pp. 968-974
    • Rich, M.W.1
  • 6
    • 0034673250 scopus 로고    scopus 로고
    • Expression of three isoforms of cGMPbinding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum
    • Lin CS, Lau A, Tu R, Lue TF. Expression of three isoforms of cGMPbinding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. Biochem Biophys Res Commun 2000;268:628-35.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 628-635
    • Lin, C.S.1    Lau, A.2    Tu, R.3    Lue, T.F.4
  • 7
    • 0033832073 scopus 로고    scopus 로고
    • Guanylyl cyclases and signaling by cyclic GMP
    • Lucas KA, Pitari GM, Kazerounian S, et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000;52:375-414.
    • (2000) Pharmacol Rev , vol.52 , pp. 375-414
    • Lucas, K.A.1    Pitari, G.M.2    Kazerounian, S.3
  • 8
    • 15944411036 scopus 로고    scopus 로고
    • Regulation of intracellular Ca2+ release in corpus cavernosum smooth muscle: Synergism between nitric oxide and cGMP
    • Williams BA, Liu C, Deyoung L, Brock GB, Sims SM. Regulation of intracellular Ca2+ release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP. Am J Physiol Cell Physiol 2005;288:C650-8.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Williams, B.A.1    Liu, C.2    Deyoung, L.3    Brock, G.B.4    Sims, S.M.5
  • 10
    • 34247881857 scopus 로고    scopus 로고
    • Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction
    • Pérez NG, Piaggio MR, Ennis IL, et al. Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. Hypertension 2007;49:1095-103.
    • (2007) Hypertension , vol.49 , pp. 1095-1103
    • Pérez, N.G.1    Piaggio, M.R.2    Ennis, I.L.3
  • 11
    • 36349033482 scopus 로고    scopus 로고
    • Phosphodiesterase type 5: Expanding roles in cardiovascular regulation
    • Kass DA, Champion HC, Beavo JA. Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circ Res 2007;101:1084-95.
    • (2007) Circ Res , vol.101 , pp. 1084-1095
    • Kass, D.A.1    Champion, H.C.2    Beavo, J.A.3
  • 12
    • 78049236623 scopus 로고    scopus 로고
    • Clinical use of phosphodiesterase-5 inhibitors in chronic heart failure
    • Guazzi M. Clinical use of phosphodiesterase-5 inhibitors in chronic heart failure. Circ Heart Fail 2008;1:272-80.
    • (2008) Circ Heart Fail , vol.1 , pp. 272-280
    • Guazzi, M.1
  • 13
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006;5:689-702.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 14
    • 34848914106 scopus 로고    scopus 로고
    • Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    • Lewis GD, Shah R, Shahzad K, et al. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation 2007;116:1555-62.
    • (2007) Circulation , vol.116 , pp. 1555-1562
    • Lewis, G.D.1    Shah, R.2    Shahzad, K.3
  • 15
    • 36148948551 scopus 로고    scopus 로고
    • Long-term use of sildenafil in the therapeutic management of heart failure
    • Guazzi M, Samaja M, Arena R, Vicenzi M, Guazzi MD. Long-term use of sildenafil in the therapeutic management of heart failure. J Am Coll Cardiol 2007;50:2136-44.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 2136-2144
    • Guazzi, M.1    Samaja, M.2    Arena, R.3    Vicenzi, M.4    Guazzi, M.D.5
  • 16
    • 41249101721 scopus 로고    scopus 로고
    • Effects of 5E-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: A double-blind, placebo-controlled clinical trial
    • Behling A, Rohde LE, Colombo FC, Goldraich L, Stein R, Clausell N. Effects of 5E-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial. J Card Fail 2008;14:189-97.
    • (2008) J Card Fail , vol.14 , pp. 189-197
    • Behling, A.1    Rohde, L.E.2    Colombo, F.C.3    Goldraich, L.4    Stein, R.5    Clausell, N.6
  • 17
    • 79551580284 scopus 로고    scopus 로고
    • PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: Results of a 1-year, prospective, randomized, placebo-controlled study
    • Guazzi M, Vicenzi M, Arena R, Guazzi MD. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail 2011;4:8-17.
    • (2011) Circ Heart Fail , vol.4 , pp. 8-17
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3    Guazzi, M.D.4
  • 18
    • 0033858827 scopus 로고    scopus 로고
    • Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure
    • Katz SD, Balidemaj K, Homma S, Wu H, Wang J, Maybaum S. Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol 2000;36:845-51.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 845-851
    • Katz, S.D.1    Balidemaj, K.2    Homma, S.3    Wu, H.4    Wang, J.5    Maybaum, S.6
  • 19
    • 0037183551 scopus 로고    scopus 로고
    • Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: A double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction
    • Bocchi EA, Guimarãs G, Mocelin A, Bacal F, Bellotti G, Ramires JF. Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 2002;106:1097-103.
    • (2002) Circulation , vol.106 , pp. 1097-1103
    • Bocchi, E.A.1    Guimarãs, G.2    Mocelin, A.3    Bacal, F.4    Bellotti, G.5    Ramires, J.F.6
  • 20
    • 4744351594 scopus 로고    scopus 로고
    • Influences of sildenafil on lung function and hemodynamics in patients with chronic heart failure
    • Guazzi M, Tumminello G, Di Marco FD, Guazzi MD. Influences of sildenafil on lung function and hemodynamics in patients with chronic heart failure. Clin Pharmacol Ther 2004;76:371-8.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 371-378
    • Guazzi, M.1    Tumminello, G.2    di Marco, F.D.3    Guazzi, M.D.4
  • 21
    • 10644252927 scopus 로고    scopus 로고
    • The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilator efficiency, and oxygen uptake kinetics in chronic heart failure
    • Guazzi M, Tumminello G, Di Marco F, Fiorentini C, Guazzi MD. The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilator efficiency, and oxygen uptake kinetics in chronic heart failure. J Am Coll Cardiol 2004;44:2239-48.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2239-2248
    • Guazzi, M.1    Tumminello, G.2    di Marco, F.3    Fiorentini, C.4    Guazzi, M.D.5
  • 22
    • 27644562803 scopus 로고    scopus 로고
    • Effect of sildenafil on cardiac performance in patients with heart failure
    • Hirata K, Adji A, Vlachopoulos C, O'Rourke MF. Effect of sildenafil on cardiac performance in patients with heart failure. Am J Cardiol 2005;96:1436-40.
    • (2005) Am J Cardiol , vol.96 , pp. 1436-1440
    • Hirata, K.1    Adji, A.2    Vlachopoulos, C.3    O'Rourke, M.F.4
  • 23
    • 17144428934 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme and phosphodiesterase type 5 improves endothelial function in heart failure
    • Hryniewicz K, Dimayuga C, Hudaihed A, et al. Inhibition of angiotensin-converting enzyme and phosphodiesterase type 5 improves endothelial function in heart failure. Clin Sci (Lond) 2005;108:331-8.
    • (2005) Clin Sci (Lond) , vol.108 , pp. 331-338
    • Hryniewicz, K.1    Dimayuga, C.2    Hudaihed, A.3
  • 24
    • 33846099444 scopus 로고    scopus 로고
    • Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    • Lewis GD, Shah R, Shahzad K, et al. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation 2007;115:59-66.
    • (2007) Circulation , vol.115 , pp. 59-66
    • Lewis, G.D.1    Shah, R.2    Shahzad, K.3
  • 25
    • 38349118096 scopus 로고    scopus 로고
    • Endothelium-mediated modulation of ergoreflex and improvement in exercise ventilation by acute sildenafil in heart failure patients
    • Guazzi M, Casali M, Berti F, Rossoni G, Colonna VD, Guazzi MD. Endothelium-mediated modulation of ergoreflex and improvement in exercise ventilation by acute sildenafil in heart failure patients. Clin Pharmacol Ther 2008;83:336-41.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 336-341
    • Guazzi, M.1    Casali, M.2    Berti, F.3    Rossoni, G.4    Colonna, V.D.5    Guazzi, M.D.6
  • 26
    • 79960396933 scopus 로고    scopus 로고
    • Pulmonary hypertension in heart failure with preserved ejection fraction: A target of phosphodiesterase-5 inhibition in a 1-year study
    • Guazzi M, Vicenzi M, Arena R, Guazzi MD. Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study. Circulation 2011;124:164-74.
    • (2011) Circulation , vol.124 , pp. 164-174
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3    Guazzi, M.D.4
  • 28
    • 83155177442 scopus 로고    scopus 로고
    • Product information, New York: Pfizer Inc., January
    • Product information. Viagra (sildenafil). New York: Pfizer Inc., January 2011.
    • (2011) Viagra (sildenafil)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.