Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression

Ophthalmic Research

Volumn 47, Issue 3, 2012, Pages 122-127

  Huang, Lina ^a   Zhao, Shihong ^a   Zhang, John H ^c   Sun, Xuejun ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c LOMA LINDA UNIVERSITY   (United States)

Author keywords

Hydrogen saline; Hyperoxia; Oxidative stress; Retinal neovascularization; Vascular endothelial growth factor

Indexed keywords

HYDROGEN; HYDROGEN SALINE; MALONALDEHYDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE IMAGING; HISTOPATHOLOGY; HYPEROXIA; HYPEROXIA INDUCED RETINOPATHY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA NEOVASCULARIZATION; RETINOPATHY;

ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; HYDROGEN; HYPEROXIA; MALONDIALDEHYDE; MICE; OXIDATIVE STRESS; RETINAL NEOVASCULARIZATION; SODIUM CHLORIDE; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 83155176928     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000329600     Document Type: Article

References (25)

1. Guaiquil V, Swendeman S, Yoshida T, et al: ADAM9 is involved in pathological retinal neovascularization. Mol Cell Biol 2009;10:2694-2703.
2. Chen J, Connor KM, Aderman CM, et al: Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci 2009;50:1329-1335.
3. Kim JH, Lee BJ, Kim JH, et al: Anti-angiogenic effect of caffeic acid on retinal neovascularization. Vasc Pharmacol 2009;52:262-267.
4. Dong A, Xie B, Shen J, et al: Oxidative stress promotes ocular neovascularization. J Cell Physiol 2009;219:544-552.
5. Bartoli M, Al-Shabrawey M, Labazi M, et al: HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 2009;50:4934-4940.
6. Dorrell M, Aguilar E, Jacobson R, et al: Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization- associated oxidative stress. J Clin Invest 2009;119:611-623.
7. Zhao SH, Huang LN, Wu JH, et al: Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy. Mol Vision 2009;15:1231-1242.
8. Guma M, Rius J, Duong-Polk KX, et al: Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. PNAS 2009;106:8760-8765.
9. Iranmanesh R, Eandi CM, Peiretti E, et al: The nature and frequency of neovascular age-related macular degeneration. Eur J Ophthalmol 2007;17:75-83. (Pubitemid 46580602)
10. Gragoudas ES, Adamis AP, Cunningham ET Jr, et al: Pegaptanib for neovascular age related macular degeneration. N Engl J Med 2004;351:2805-2816. (Pubitemid 40051904)
11. Cai J, Kang Z, Liu K, et al: Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res 2009;1256:129-137.
12. Oharazawa H, Igarashi T, Yokota T, et al: Rapid diffusion of hydrogen protects the retina: administration to the eye of hydrogen-containing saline in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 2009;50:4934-4940.
13. Ohsawa I, Ishikawa M, Takahashi K, et al: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007;13:688-694. (Pubitemid 46889750)
14. Fukuda K, Asoh S, Ishikawa M, et al: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007;361:670-674. (Pubitemid 47238041)
15. Hayashida K, Sano M, Ohsawa I, et al: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008;373:30-35.
16. Kubota M, Shimmura S, Kubota S, et al: Hydrogen and N-acetyl- L -cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci 2011;52:427-433.
17. Smith LE, Wesolowski E, McLellan A, et al: Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994;35:101-111. (Pubitemid 24046832)
18. Aiello LP, Pierce EA, Foley ED, et al: Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF receptor chimeric proteins. Proc Natl Acad Sci USA 1995;92:10457-10461.
19. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH: Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 1995;92:905-909.
20. Gu X, Samuel S, El-Shabrawey M, et al: Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 2002;43:496-502. (Pubitemid 34113234)
21. Leske DA, Wu J, Fautseh MP, et al: The role of VEGF and IGF-1 in a hypercarbic oxygen-induced retinopathy rat model of ROP. Mol Vis 2004;21:43-50. (Pubitemid 38628978)
22. Finkel T: Signal transduction by reactive oxygen species in non-phagocytic cells. J Leukoc Biol 1999;65:337-340.
23. Hsu TC, Young MR, Cmarik J, et al: Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med 2000;28:1338-1348. (Pubitemid 30621478)
24. 2 via an antioxidant response element. FASEB J 2005;19:2085-2087.
25. Okamoto A, Iwamoto Y, Maru Y: Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. Mol Cell Biol 2006;26:108710-108797.