Advances in understanding and treatment of Tourette syndrome

Nature Reviews Neurology

Volumn 7, Issue 12, 2011, Pages 667-676

  McNaught, Kevin St P ^a   Mink, Jonathan W ^b  

^a Medical and Scientific Programs   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; ATOMOXETINE; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; BOTULINUM TOXIN; CENTRAL STIMULANT AGENT; CLONIDINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; GUANFACINE; HALOPERIDOL; METHYLPHENIDATE; PIMOZIDE; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TETRABENAZINE;

ABDOMINAL DISCOMFORT; ABNORMAL SENSATION; AKATHISIA; ASPIRATION; ATTENTION DEFICIT DISORDER; AUTOSOMAL DOMINANT INHERITANCE; BASAL GANGLION; BEHAVIOR DISORDER; BEHAVIOR THERAPY; BEHAVIORAL ACTIVATION; BLURRED VISION; BRAIN DEPTH STIMULATION; CHOLINERGIC SYSTEM; CLINICAL FEATURE; COGNITIVE DEFECT; COGNITIVE THERAPY; COMORBIDITY; DECREASED APPETITE; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE SEVERITY; DIZYGOTIC TWINS; DIZZINESS; DRUG INDICATION; DYSPHAGIA; DYSTONIA; ETHNIC GROUP; FATIGUE; GABAERGIC SYSTEM; GENE; GENETIC ASSOCIATION; GILLES DE LA TOURETTE SYNDROME; GLOBUS PALLIDUS; HDC GENE; HEART MUSCLE CONDUCTION DISTURBANCE; HISTORY OF MEDICINE; HOARSENESS; HUMAN; HYPERTENSION; HYPOPHONIA; HYPOTENSION; INSOMNIA; INVOLUNTARY MOVEMENT; IRRITABILITY; LANGUAGE DISABILITY; LINKAGE ANALYSIS; MONOZYGOTIC TWINS; MOTOR CORTEX; MOTOR DYSFUNCTION; MOTOR RESTLESSNESS; MOTOR TIC; MUSCLE STIFFNESS; NEUROANATOMY; OBSESSIVE COMPULSIVE DISORDER; PARKINSONISM; PATHOPHYSIOLOGY; PATIENT EDUCATION; PHOBIA; PHONIC TIC; PREMONITORY URGE SENSATION; PREVALENCE; PRIORITY JOURNAL; REBOUND HYPERTENSION; REVIEW; RISK FACTOR; SCHOOL PHOBIA; SEDATION; SIDE EFFECT; SLITRK1 GENE; SYMPTOM; TIC; TREMOR; VOCAL TIC; VOCALIZATION; WEAKNESS; WEIGHT GAIN;

ANIMALS; BEHAVIOR THERAPY; COMPREHENSION; DEEP BRAIN STIMULATION; DOPAMINE ANTAGONISTS; HUMANS; TOURETTE SYNDROME; TREATMENT OUTCOME;

EID: 83055186511     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2011.167     Document Type: Review

References (80)

1. Gilles de la Tourette, G. Étude sur une affection nerveuse caractérisée par de l'incoordination motrice accompagnée d'écholalie et de coprolalie [French]. Arch. Neurol. 9, 158-200 (1885).
2. Walusinski, O. Jean-Martin Charcot's house officers at La Salpêtrière Hospital. Front. Neurol. Neurosci. 29, 9-35 (2011).
3. Trivet, H. A., Chien, H. F., Munhoz, R. P. & Barbosa, E. R. Charcot's contribution to the study of Tourette syndrome. Arq. Neuropsiquiatr. 66, 918-921 (2008).
4. Rickards, H. & Cavanna, A. E. Gilles de la Tourette: the man behind the syndrome. J. Psychosom. Res. 67, 469-474 (2009).
5. Goetz, C. G., Chmura, T. A. & Lanska, D. J. History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. Mov. Disord. 16, 346-349 (2001). (Pubitemid 36049982)
6. Finger, S. Origins of Neuroscience: the History of Explorations into Brain Function 220-239 (Oxford University Press, New York, 1994).
7. Itard, J. M. Mémoire sur quelques functions involontaires des appareils de la locomotion, de la préhension et de la voix [French]. Arch. Gen. Med. 8, 385-407 (1825).
8. Trousseau, A. Clinique Médicale de l'Hôtel Dieu de Paris 264-271 (J.-B. Bailliere, Paris, 1868).
9. Rickards, H., Woolf, I. & Canvanna, A. E. "Trousseau's disease:" a description of the Gilles de la Tourette syndrome 12 years before 1885. Mov. Disord. 25, 2285-2289 (2010).
10. Hughlings Jackson, J. Clinical Lectures and Reports to the London Hospital 1, 452 (1884).
11. Freeman, R. D. et al. Coprophenomena in Tourette syndrome. Dev. Med. Child. Neurol. 51, 218-227 (2009).
12. Steinberg, T. et al. Tic disorders and the premonitory urge. J. Neurol. Transm. 117, 277-284 (2010).
13. Kwak, C., Dat Vuong, K. & Jankovic, J. Premonitory sensory phenomenon in Tourette's syndrome. Mov. Disord. 18, 1530-1533 (2003). (Pubitemid 38035379)
14. Eddy, C. M. et al. Clinical correlates of quality of life in Tourette syndrome. Mov. Disord. 26, 735-738 (2011).
15. Lewin, A. B. et al. A phenomenological investigation of women with Tourette or other chronic tic disorders. Compr. Psychiatry http://dx.doi.org/10. 1016/j.comppsych.2011.07.004.
16. Kurlan, R. et al. The behavioral spectrum of tic disorders: a community-based study. Neurology 59, 414-420 (2002). (Pubitemid 34857935)
17. Freeman, R. D. & Tourette Syndrome International Database Consortium. Tic disorders and ADHD: answers from a world-wide clinical dataset on Tourette syndrome. Eur. Child. Adolesc. Psychiatry 16, 15-23 (2007).
18. Zinner, S. H. & Coffey, B. J. Developmental and behavioral disorders grown up: Tourette's disorder. J. Dev. Behav. Pediatr. 30, 560-573 (2009).
19. O'Rourke, J. A. et al. The familial association of tourette's disorder and ADHD: The impact of OCD symptoms. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156, 553-560 (2011).
20. Bloch, M. H. & Leckman, J. F. Clinical course of Tourette syndrome. J. Psychosom. Res. 67, 497-501 (2009).
21. Jankovic, J., Gelineau-Kattner, R. & Davidson, A. Tourette's syndrome in adults. Mov. Disord. 25, 2171-2175 (2010).
22. Trajanovic, N. N., Voloh, I., Shapiro, C. M. & Sandor, P. REM sleep behaviour disorder in a child with Tourette's syndrome. Can. J. Neurol. Sci. 31, 572-575 (2004). (Pubitemid 39587211)
23. Lombroso, P. J., Mack, G., Scahill, L., King, R. A. & Leckman, J. F. Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress: a family study. Neurology 41, 1984-1987 (1991).
24. Leckman, J. F., Bloch, M. H., Scahill, L. & King, R. A. Tourette syndrome: the self under siege. J. Child. Neurol. 21, 642-649 (2006). (Pubitemid 44295122)
25. Conelea, C. A. et al. Exploring the impact of chronic tic disorders on youth: results from the Tourette Syndrome Impact Survey. Child. Psychiatry Hum. Dev. 42, 219-242 (2011).
26. Freeman, R. D. et al. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev. Med. Child Neurol. 42, 436-447 (2000). (Pubitemid 30427051)
27. Robertson, M. M., Eapen, V. & Cavanna, A. E. The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective. J. Psychosom. Res. 67, 475-483 (2009).
28. Centers for Disease Control and Prevention (CDC). Prevalence of diagnosed Tourette syndrome in persons aged 6-17 years-United States, 2007. MMWR Morb. Mortal. Wkly Rep. 58, 581-585 (2009).
29. Kurlan, R. et al. Prevalence of tics in schoolchildren and association with placement in special education. Neurology 57, 1383-1388 (2001). (Pubitemid 32995716)
30. Scahill, L., Sukhodolsky, D. G., Williams, S. K. & Leckman, J. F. Public health significance of tic disorders in children and adolescents. Adv. Neurol. 96, 240-248 (2005).
31. Motlagh, M. G. et al. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre-and perinatal risk factors associated with ADHD and Tourette syndrome. Eur. Child Adolesc. Psychiatry 19, 755-764 (2010).
32. Murphy, T. K., Kurlan, R. & Leckman, J. The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward. J. Child Adolesc. Psychopharm. 20, 317-331 (2010).
33. O'Rourke, J. A., Scharf, J. M., Yu, D. & Pauls, D. L. The genetics of Tourette syndrome: a review. J. Psychosom. Res. 67, 533-545 (2009).
34. State, M. W. The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Neuron 68, 254-269 (2010).
35. Pauls, D. L., Cohen, D. J., Heimbuch, R., Detlor, J. & Kidd, K. K. Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics. Arch. Gen. Psychiatry 38, 1091-1093 (1981). (Pubitemid 11013051)
36. Kidd, K. K., Prusoff, B. A. & Cohen, D. J. Familial pattern of Gilles de la Tourette syndrome. Arch. Gen. Psychiatry 37, 1336-1339 (1980). (Pubitemid 11204071)
37. Price, R. A., Kidd, K. K., Cohen, D. J., Pauls, D. & Leckman, J. F. A twin study of Tourette syndrome. Arch. Gen. Psychiatry 42, 815-820 (1985). (Pubitemid 15244833)
38. Hyde, T. M., Aaronson, B. A., Randolph, C., Rickler, K. C. & Weinberger, D. R. Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins. Neurology 42, 652-658 (1992).
39. Bolton, D., Rijsdijk, F., O'Connor, T. G., Perrin, S. & Eley, T. C. Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins. Psychol. Med. 37, 39-48 (2007). (Pubitemid 46043841)
40. Kurlan, R., Eapen, V., Stern, J., McDermott, M. P. & Robertson, M. M. Bilineal transmission in Tourette's syndrome families. Neurology 44, 2336-2342 (1994). (Pubitemid 24382733)
41. Tourette Syndrome Association International Consortium for Genetics. Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Am. J. Human. Genet. 80, 265-272 (2007).
42. Abelson, J. F. et al. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310, 317-320 (2005). (Pubitemid 41457198)
43. Ercan-Sencicek, A. G. et al. l-histidine decarboxylase and Tourette's syndrome. N. Engl. J. Med. 362, 1901-1908 (2010).
44. Sundaram, S. K., Huq, A. M., Wilson, B. J. & Chugani, H. T. Tourette syndrome is associated with recurrent exonic copy number variants. Neurology 74, 1583-1590 (2010).
45. Leckman, J. F., Bloch, M. H., Smith, M. E., Larabi, D. & Hampson, M. Neurobiological substrates of Tourette's disorder. J. Child Adolesc. Psychopharmacol. 20, 237-247 (2010).
46. Kataoka, Y. et al. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. J. Comp. Neurol. 518, 277-291 (2010).
47. Kalanithi, P. S. et al. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proc. Natl Acad. Sci. USA 102, 13307-13312 (2005). (Pubitemid 41325019)
48. Rickards, H. Functional neuroimaging in Tourette syndrome. J. Psychosom. Res. 67, 575-584 (2009).
49. Hyde, T. M. et al. Cerebral morphometric abnormalities in Tourette's syndrome: a quantitative MRI study of monozygotic twins. Neurology 45, 1176-1182 (1995).
50. Peterson, B. S. et al. Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Arch. Gen. Psychiatry 60, 415-424 (2003). (Pubitemid 36403003)
51. Lee, J. S. Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. Acta Psychiatr. Scand. 113, 64-67 (2006).
52. Sowell, E. R. et al. Thinning of sensorimotor cortices in children with Tourette syndrome. Nat. Neurosci. 11, 637-639 (2008). (Pubitemid 351748118)
53. Peterson, B. S. et al. A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch. Gen. Psychiatry 55, 326-333 (1998). (Pubitemid 28173622)
54. Bohlhalter, S. et al. Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 129, 2029-2037 (2006). (Pubitemid 44289068)
55. Krack, P., Hariz, M. I., Baunez, C., Guridi, J. & Obeso, J. A. Deep brain stimulation: from neurology to psychiatry. Trends Neurosci. 33, 474-484 (2010).
56. Hassler, R. & Dieckmann, G. Traitement stereotaxique des tics et cris inarticulés ou coprolaliques considérés comme phénomène d'obsession motrice au cours de la maladie de Gilles de la Tourette [French]. Rev. Neurol. (Paris) 123, 89-100 (1970).
57. Temel, Y. & Visser-Vandewalle, V. Surgery in Tourette syndrome. Mov. Disord. 19, 3-14 (2004). (Pubitemid 38559615)
58. Servello, D., Porta, M., Sassi, M., Brambilla, A. & Robertson. M. M. Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. J. Neurol. Neurosurg. Psychiatry 79, 136-142 (2008). (Pubitemid 351236542)
59. Ackermans, L. et al. Deep brain stimulation in Tourette's syndrome: two targets? Mov. Disord. 21, 709-713 (2006). (Pubitemid 43792758)
60. Shale, H., Fahn, S. & Mayeux, R. Tics in a patient with Parkinson's disease. Mov. Disord. 1, 79-83 (1986).
61. Parraga, H. C., Harris, K. M., Parraga, K. L., Balen, G. M. & Cruz, C. An overview of the treatment of Tourette's disorder and tics. J. Child Adolesc. Psychopharmacol. 20, 249-262 (2010).
62. Singer, H. S. Treatment of tics and Tourette syndrome. Curr. Treat. Options Neurol. 12, 539-561 (2010).
63. Zinner, S. H. & Mink, J. W. Movement disorders I: tics and stereotypies. Pediatr. Rev. 31, 223-233 (2010).
64. Conelea, C. A. et al. Exploring the impact of chronic tic disorders on youth: results from the Tourette Syndrome Impact Survey. Child Psychiatry Hum. Dev. 42, 219-242 (2011).
65. Piacentini, J. et al. Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA. 303, 1929-1937 (2010).
66. Ward, H. E., Hwynn, N. & Okun, M. S. Update on deep brain stimulation for neuropsychiatric disorders. Neurobiol. Dis. 38, 346-353 (2010).
67. Shapiro, A. K. & Shapiro, E. Treatment of Gilles de la Tourette's syndrome with haloperidol. Br. J. Psychiatry 114, 345-350 (1968).
68. Kwak, C. H., Hanna, P. A. & Jankovic, J. Botulinum toxin in the treatment of tics. Arch. Neurol. 57, 1190-1193 (2000). (Pubitemid 30644667)
69. Ondo, W. G., Jong, D. & Davis, A. Comparison of weight gain in treatments for Tourette syndrome: tetrabenazine versus neuroleptic drugs. J. Child Neurol. 23, 435-437 (2008). (Pubitemid 351460709)
70. Erenberg, G., Cruse, R. P. & Rothner, A. D. Gilles de la Tourette's syndrome: effects of stimulant drugs. Neurology 35, 1346-1348 (1985). (Pubitemid 15021601)
71. Tourette's Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology 58, 527-536 (2002).
72. Bloch, M. H., Panza, K. E., Landeros-Weisenberger, A. & Leckman, J. F. Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. J. Am. Acad. Child Adolesc. Psychiatry 48, 884-893 (2009).
73. Miguel, E. C., Shavitt, R. G., Ferrão, Y. A., Brotto, S. A. & Diniz, J. B. How to treat OCD in patients with Tourette syndrome. J. Psychosom. Res. 55, 49-57 (2003). (Pubitemid 36949569)
74. Azrin, N. H. & Nunn, R. G. Habit-reversal. a method of eliminating nervous habits and tics. Behav. Res. Ther. 11, 619-628 (1973).
75. Verdellen, C. W., Keijsers, G. P., Cath, D. C. & Hoogduin, C. A. Exposure with response prevention versus habit reversal in Tourette's syndrome: a controlled study. Behav. Res. Ther. 24, 501-511 (2004). (Pubitemid 38368901)
76. Burdick, A. et al. Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive-compulsive disorder. Neurocase 16, 321-330 (2010).
77. Dueck, A. et al. Deep brain stimulation of globus pallidus internus in a 16-year-old boy with severe Tourette syndrome and mental retardation. Neuropediatrics 40, 239-242 (2009).
78. Mink, J. W. et al. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mov. Disord. 21, 1831-1838 (2006). (Pubitemid 44848927)
79. Kompoliti, K., Fan, W. & Leurgans, S. Complementary and alternative medicine use in Gilles de la Tourette syndrome. Mov. Disord. 24, 2015-2019 (2009).
80. O'Connor, K. P. et al. Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. Behav. Res. Ther. 47, 1090-1095 (2009).