Indole-3-carbinol inhibits telomerase activity and gene expression in prostate cancer cell lines

Anticancer Research

Volumn 31, Issue 11, 2011, Pages 3733-3737

  Adler, Shulamit ^a   Rashid, Gloria ^a   Klein, Ami ^a,b  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cell viability; Diethylstilbestrol; Indole; Prostate cancer; Telomerase

Indexed keywords

3 INDOLEMETHANOL; ANTINEOPLASTIC AGENT; DIETHYLSTILBESTROL; MESSENGER RNA; TELOMERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL STRAIN LNCAP; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; REAL TIME POLYMERASE CHAIN REACTION;

ANTICARCINOGENIC AGENTS; DIETHYLSTILBESTROL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROGENS, NON-STEROIDAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; MALE; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 83055179608     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kim NW, Piatszsek MA, Browse KR, Marley CB, West MD and Ho PLC: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
2. Thyu MS: Telomeres, telomerases and immortality. J Natl Cancer Inst 87: 884-895, 1995.
3. Greider CW: Telomerase activity, cell proliferation and cancer. Proc Nat Acad Sci USA 95: 90-92, 1998.
4. Greider CW: Telomerase and senescence: the history, experiment, the future. Curr Biol 8: 178-181, 1998.
5. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791, 1997.
6. Sommerfeld HJ, Meeker AK, Piatyszek MA, Bova GS, Shay JW and Coffey DS: Telomerase activity: a prevalent marker of malignant human prostate tissue. Cancer Res 56: 218-222, 1996. (Pubitemid 26011466)
7. Scates DK, Muir GH, Venitt S and Carmichael PL: Detection of telomerase activity in human prostate: a marker for prostatic cancer? Br J Urol 80: 263-268, 1997. (Pubitemid 28318894)
8. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC and Yu J: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
9. Bisoffi M, Chakerian AE, Fore ML, Bryant JE, Hernandez JP, Moyzis RK and Griffith JK.: Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA. Eur J Cancer 34: 1242-1249, 1996.
10. Geier R, Shulamit A, Rashid G and Klein A: The synthetic estrogen diethylstilbestrol (DES) inhibits the telomerase activity and gene expression of prostate cancer cells. Prostate 70: 1307-1312, 2010.
11. Nachshon-Kedmi M, Yannai S, Haj A and Fares F: Indole-3-carbinol and 3,3′ diindolymethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 41: 745-752, 2003. (Pubitemid 36555879)
12. Zhang, K, Hsu BAJ, Kinseth BAM, Bjeldanes LF and Firestone GL: Indole-3-carbinol induces a G-1 cell cycle arrest and inhibits prostate specific antigen production in human LNCaP prostate carcinoma cells. Cancer 98: 2511-2520, 2003. (Pubitemid 37466668)
13. Chinni SR, Li, Y, Upadhay, S, Koppolu, PK and Sarker FH: Indole-3-carbinol induced cell growth inhibition, G-1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20: 2927-2936, 2001. (Pubitemid 33027760)
14. Chinni SR and Sarkar FH: AKT inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res 8: 1228-1236, 2002. (Pubitemid 35177379)
15. Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF and Firestone GL: Indole-3-carbinol-mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. Biochem Pharmacol 72: 1714-1723, 2006. (Pubitemid 44765004)
16. Sarkar FH and Li Y: Indole-3-carbinol and prostate cancer. J Nutr 134: 3493S-3498S, 2004. (Pubitemid 39587595)
17. Shpitz B, Zimlichman S, Zemer R, Bomstein Y, Zehavi T, Liverant S, Bernhim J, Kaufman Z, Klein E, Shapira Y and Klein A: Telomerase activity in ductal carcinoma in situ of the breast. Breast Can Res Treat 58: 65-69, 1999. (Pubitemid 30003872)
18. Li Y, Li X and Sarkar FH: Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. J Nutr 133: 1011-1019, 2003. (Pubitemid 36407118)
19. Chang JT, Lu YC, Chen YC, Tseng PC, Chen YL, Fang CW and Cheng AJ: hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. Br J Can 94: 870-878, 2006.
20. Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ and Ségal-Bendirdjian E: Immunodetection of human telomerase reverse-transcriptase (hTERT) reappraised: nucleolin and telomerase cross paths. J Cell Sci 119: 2797-2806, 2006. (Pubitemid 44184016)
21. Souli E, Machluf M, Morgenstern A, Sabo E and Yannai S: Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumours in mice. Food Chem Toxicology 46: 863-870, 2008. (Pubitemid 351172558)
22. Weng JR, Tsai CH, Kulp SK, Wang D and Lin CH: A potent indole-3-carbinol derived agent with pleiotropic effects on multiple signaling pathways. Cancer Res 67: 7815-7824, 2007. (Pubitemid 47281376)