Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin

Annals of Hepatology

Volumn 11, Issue 1, 2012, Pages 77-84

  Maliken, Bryan D ^a   Avrin, William F ^c   Nelson, James E ^a   Mooney, Jody ^b   Kumar, Sankaran ^c   Kowdley, Kris V ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b VIRGINIA MASON MEDICAL CENTER   (United States)

^c Insight Magnetics   (United States)

Author keywords

Chronic liver disease; Hepatic iron content; Iron overload; MRI; SQUID

Indexed keywords

FERRITIN; IRON;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; FERRITIN BLOOD LEVEL; HEMOCHROMATOSIS; HEPATIC IRON CONTENT; HUMAN; HUMAN TISSUE; HYPERFERRITINEMIA; INTERMETHOD COMPARISON; IRON DEPLETION THERAPY; IRON OVERLOAD; LIVER BIOPSY; LIVER LEVEL; MALE; NON INVASIVE MEASUREMENT; NONALCOHOLIC FATTY LIVER; ROOM TEMPERATURE SUSCEPTOMETRY; THERAPY; VIRUS HEPATITIS;

EID: 83055179148     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31489-9     Document Type: Article

References (49)

1. Bonkovsky HL, Lambrecht RW, Shan Y. Iron as a co-morbid factor in nonhemochromatotic liver disease. Alcohol 2003; 30: 137-44.
2. Terry R. Risks of needle biopsy of the liver. Br Med J 1952; 1: 1102-5.
3. Zamcheck N, Klasusenstock O. Liver biopsy. II. The risk of needle biopsy. N Engl J Med 1953; 249: 1062-9.
4. Butensky E, Fischer R, Hudes M, Schumacher L, Williams R, Moyer TP, Vichinsky E, et al. Variability in hepatic iron concentration in percutaneous needle biopsy specimens from patients with transfusional hemosiderosis. Am J Clin Pathol 2005; 123: 146-52.
5. Nielsen P, Gunther U, Durken M, Fischer R, Dullmann J. Serum ferritin iron in iron overload and liver damage: correlation to body iron stores and diagnostic relevance. J Lab Clin Med 2000; 135: 413-8.
6. Nielsen P, Engelhardt R, Dullmann J, Fischer R. Non-invasive liver iron quantification by SQUID-biosusceptometry and serum ferritin iron as new diagnostic parameters in hereditary hemochromatosis. Blood Cells Mol Dis 2002; 29: 451-8.
7. Brittenham GM, Sheth S, Allen CJ, Farrell DE. Noninvasive methods for quantitative assessment of transfusional iron overload in sickle cell disease. Semin Hematol 2001; 38: 37-56.
8. Gomori JM, Horev G, Tamary H, Zandback J, Kornreich L, Zaizov R, Freud E, et al. Hepatic iron overload: quantitative MR imaging. Radiology 1991; 179: 367-9.
9. Thomsen C, Wiggers P, Ring-Larsen H, Christiansen E, Dalhoj J, Henriksen O, Christoffersen P. Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurements. Magn Reson Imaging 1992; 10: 867-79.
10. Kaltwasser JP, Gottschalk R, Schalk KP, Hartl W. Non-invasive quantitation of liver iron-overload by magnetic resonance imaging. Br J Haematol 1990; 74: 360-3.
11. Jensen PD, Jensen FT, Christensen T, Ellegaard J. Non-invasive assessment of tissue iron overload in the liver by magnetic resonance imaging. Br J Haematol 1994; 87: 171-84.
12. Bonkovsky HL, Rubin RB, Cable EE, Davidoff A, Rijcken TH, Stark DD. Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques. Radiology 1999; 212: 227-34.
13. Pardoe H, Chua-Anusorn W, St Pierre TG, Dobson J. Detection limits for ferrimagnetic particle concentrations using magnetic resonance imaging based proton transverse relaxation rate measurements. Phys Med Biol 2003; 48: N89-N95.
14. Tziomalos K, Perifanis V. Liver iron content determination by magnetic resonance imaging. World J Gastroenterol 2010; 16: 1587-97.
15. Fischer R. Liver Iron Susceptometry. In: Andrä W, Hannes Nowak (eds.). Magnetism in Medicine: A Handbook. 2nd. Ed. Berlin: Wiley-VHC; 1998, p. 286-301.
16. Fischer R, Harmatz PR. Non-invasive assessment of tissue iron overload. Hematology Am Soc Hematol Educ Program 2009; 215-21.
17. Brittenham GM, Farrell DE, Harris JW, Feldman ES, Danish EH, Muir WA, Tripp JH, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982; 307: 1671-5.
18. Pasquarelli A, Del GC, Della PS, Di LS, Pizzella V, Romani GL. A SQUID based AC susceptometer for the investigation of large samples. Phys Med Biol 1996; 41: 2533-9.
19. Carneiro AA, Baffa O, Fernandes JP, Zago MA. Theoretical evaluation of the susceptometric measurement of iron in human liver by four different susceptometers. Physiol Meas 2002; 23: 683-93.
20. Canavese C, Bergamo D, Ciccone G, Longo F, Fop F, Thea A, Martina G, et al. Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients. Kidney Int 2004; 65: 1091-8.
21. Marinelli M, Gianesin B, Avignolo C, Minganti V, Parodi S. Iron overload detection in rats by means of a susceptometer operating at room temperature. Phys Med Biol 2008; 53: 6849-60.
22. Marinelli M, Gianesin B, Balocco M, Beruto P, Bruzzone C, Carrara P, Gallusi P, et al. Total iron-overload measurement in the human liver region by the magnetic iron detector. IEEE Trans Biomed Eng 2010; 57: 2295-303.
23. Avrin WF, Kumar S. Noninvasive liver-iron measurements with a room-temperature susceptometer. Physiol Meas 2007; 28: 349-61.
24. Scharfetter H, Casanas R, Rosell J. Biological tissue characterization by magnetic induction spectroscopy (MIS): requirements and limitations. IEEE Trans Biomed Eng 2003; 50: 870-80.
25. Casanas R, Scharfetter H, Altes A, Remacha A, Sarda P, Sierra J, Merwa R, et al. Measurement of liver iron overload by magnetic induction using a planar gradiometer: preliminary human results. Physiol Meas 2004; 25: 315-23.
26. Angelucci E, Muretto P, Nicolucci A, Baronciani D, Erer B, Gaziev J, Ripalti M, et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 2002; 100: 17-21.
27. Carneiro AA, Fernandes JP, de Araujo DB, Elias J Jr., Martinelli AL, Covas DT, Zago MA, et al. Liver iron concentration evaluated by two magnetic methods: magnetic resonance imaging and magnetic susceptometry. Magn Reson Med 2005; 54: 122-8.
28. Sumida Y, Yoshikawa T, Okanoue T. Role of hepatic iron in non-alcoholic steatohepatitis. Hepatol Res 2009; 39: 213-22.
29. Maliken BD, Kowdley KV. HCV and Iron Excess: The Interaction and How to Handle it. In: Foster G, Reddy K (eds.). Clinical Dilemmas in Viral Liver Disease. Oxford: Wiley- Blackwell; 2010, p. 82-7.
30. Wallace DF, Subramaniam VN. Co-factors in liver disease: the role of HFE-related hereditary hemochromatosis and iron. Biochim Biophys Acta 2009; 1790: 663-70.
31. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-9.
32. Bonkovsky HL, Jawaid Q, Tortorelli K, LeClair P, Cobb J, Lambrecht RW, Banner BF. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J Hepatol 1999; 31: 421-9.
33. George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998; 114: 311-8.
34. Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp- Arida A, Kowdley KV. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 2011; 53: 448-57.
35. Brunt EM. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol 2005; 22: 330-8.
36. Guyader D, Thirouard AS, Erdtmann L, Rakba N, Jacquelinet S, Danielou H, Perrin M, et al. Liver iron is a surrogate marker of severe fibrosis in chronic hepatitis C. J Hepatol 2007; 46: 587-95.
37. Lin TJ, Liao LY, Lin CL, Chang TA, Liu SO. Hepatic iron influences responses to combination therapy with peginterferon alfa and ribavirin in chronic hepatitis C. Hepatogastroenterology 2008; 55: 1412-5.
38. Barton AL, Banner BF, Cable EE, Bonkovsky HL. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol 1995; 103: 419-24.
39. Ikura Y, Morimoto H, Johmura H, Fukui M, Sakurai M. Relationship between hepatic iron deposits and response to interferon in chronic hepatitis C. Am J Gastroenterol 1996; 91: 1367-73.
40. Gutierrez L, Lazaro FJ, Abadia AR, Romero MS, Quintana C, Puerto MM, Patino C, et al. Bioinorganic transformations of liver iron deposits observed by tissue magnetic characterisation in a rat model. J Inorg Biochem 2006; 100: 1790-9.
41. Gutierrez L, Quintana C, Patino C, Bueno J, Coppin H, Roth MP, Lazaro FJ. Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation. Biochim Biophys Act 2009; 1792: 541-7.
42. Fischer R, Engelhardt R, Nielsen P. The influence of thorax tissue in biomagnetic liver susceptometry. Proceedings, 13th International Conference on Biomagnetism. 2002; 1063-5.
43. Kleiner DE, Brunt EM, van NM, Behling C, Contos MJ, Cummings OW, Ferrell LD, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
44. Olynyk J, Hall P, Sallie R, Reed W, Shilkin K, Mackinnon M. Computerized measurement of iron in liver biopsies: a comparison with biochemical iron measurement. Hepatology 1990; 12: 26-30.
45. Olynyk J, Williams P, Fudge A, Pulbrook S, Kerr R, Mackinnon M, Hall P. Fine-needle aspiration biopsy for the measurement of hepatic iron concentration. Hepatology 1992; 15: 502-6.
46. Olynyk JK, O'Neill R, Britton RS, Bacon BR. Determination of hepatic iron concentration in fresh and paraffin-embedded tissue: diagnostic implications. Gastroenterology 1994; 106: 674-7.
47. Starr T, Fischer R, Ewing T, et al. A new generation SQUID biosusceptometer. Proceedings, 12th International Conference on Biomagnetism. 2000; 986-9.
48. Paulson DN, Fagaly RL, Toussaint RM, Fischer R. Biomagnetic Susceptometer with SQUID Instrumentation. IEEE Transactions on Magnetics 1991; 27: 3249-52.
49. Lentner C (ed.). Geigy Scientific Tables. Basel: Ciba Pharmaceutical; 1981.