Non-invasive liver iron quantification by SQUID-biosusceptometry and serum ferritin iron as new diagnostic parameters in hereditary hemochromatosis

Blood cells, molecules & diseases

Volumn 29, Issue 3, 2002, Pages 451-458

  Nielsen, Peter ^a   Engelhardt, Rainer ^a   Düllmann, Jochen ^a   Fischer, Roland ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Diagnostic parameters; Ferritin iron; Hereditary hemochromatosis; Liver iron; SQUID biosusceptometry

Indexed keywords

FERRITIN; IRON;

ARTICLE; BLOOD; HEMOCHROMATOSIS; HUMAN; LIVER; METABOLISM;

FERRITINS; HEMOCHROMATOSIS; HUMANS; IRON; LIVER;

EID: 0347509327     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2002.0583     Document Type: Article

References (24)

1. J.N. Feder A. Gnirke W. Thomas Z. Tsuchihashi D.A. Ruddy A. Basava F. Dormishian R. Domingo Jr. M.C. Ellis A. Fullan L.M. Hinton N.L. Jones B.E. Kimmel G.S. Kronmal P. Lauer V.K. Lee D.B. Loeb F.A. Mapa E. McClelland N.C. Meyer G.A. Mintier N. Moeller T. Moore E. Morikang C.E. Prass L. Qiuntana S.M. Starnes R.C. Schatzmann K.J. Brunke D. Drauna N.J. Risch B.R. Bacon R.K. Wolff A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat. Genet. 13 1996 399 408
2. C. 2Camaschella A. Roetto A. Cali M. De Gobbi G. Garozzo M. Carella N. Majorano A. Totaro P. Gasparini The gene TFR2 is mutated in a new type of haemochromatosis to 7q22 Nat. Genet. 25 2000 14 15
3. G. Montosi A. Donovan A. Totaro C. Garuti E. Pignatti S. Cassanelli C.C. Trenor P. Gasparini N.C. Andrews A. Pietrangelo Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene J. Clin. Invest. 108 2001 619 623
4. A.T. Merryweather-Clarke J.J. Pointon J.D. Shearman K.J. Robson Global prevalence of putative haemochromatosis mutations J. Med. Genet. 34 1997 275 278
5. R. Gottschalk C. Seidl T. Löffler E. Seifried D. Hoelzer J.P. Kaltwasser HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis Tissue Antigens 51 1998 270 275
6. P. Nielsen S. Carpinteiro R. Fischer J.M. Cabeda G. Porto E.E. Gabbe Prevalence of the C282Y-and the H63D-mutations in the HFE-gene in patients with hereditary haemochromatosis and in control subjects from Northern Germany Brit. J. Haematol. 103 1998 842 845
7. Powell, L. W.1994Primary iron overload. In Iron Metabolism in Health and Disease (Brock, J. H., Halliday, J. W., Pippard, M. J., Powell, L. W., Eds.) pp. 227–270. Saunders, London.
8. M.L. Bassett Haemochromatosis: Iron still matters Intern. Med. J. 31 2001 237 242
9. V. Herbert E. Jayatilleke S. Shaw A.S. Rosman P. Giardina R.W. Grady B. Bowman E.W. Gunter Serum ferritin iron, a new test, measures human body iron stores unconfounded by inflammation Stem Cells 15 1997 291 296
10. J.P. Kaltwasser R. Gottschalk K.P. Schalk W. Hartl Non-invasive quantification of liver iron-overload by magnetic resonance imaging Brit. J. Haematol. 74 1990 360 363
11. R. Engelhardt J.H. Langkowski R. Fischer P. Nielsen H. Kooijmann H.C. Heinrich E. Bücheler Liver iron quantification: studies in aqueous iron solutions, iron overloaded rats and patients with hereditary hemochromatosis Magn. Reson. Imaging 12 1994 007 999
12. P.R. Clark T.G. St. Pierre Quantitative mapping of transverse relaxivity (1/T) in hepatic iron overload: a single spin-echo imaging methodology Magn. Reson. Imaging 18 2000 431 438
13. Fischer, R.1998Liver iron susceptometry. In Magnetism in Medicine (Andrä, W., Nowak, H., Eds) pp. 286–301. Wiley-VCH Berlin, New York.
14. P. Nielsen R. Fischer R. Engelhardt B. Dresow E.E Gabbe Neue Möglichkeiten in der Diagnose der hereditären Hämochromatose. HFE-Mutations-Diagnostik und nichtinvasive Leber-Eisen-Quantifizierung mit einem SQUID- Biosusceptometer Deutsches Ärzteblatt 95 1998 A2915 2921
15. Fischer, R., Engelhardt, R., Heinrich, H.C., Kessler, M., and Nielsen, P.1989The calibration problem in liver iron susceptometry. In Advances in Biomagnetism (Williamson, S.J., Hoke, M., Stroink, G., Kotani, M., Eds), pp. 501–504. Plenum, New York
16. P. Nielsen U. Günther M. Dürken R. Fischer J. Düllmann Serum ferritin iron in iron overload and liver damage : correlation to body iron stores and diagnostic relevance J. Lab. Clin. Med. 135 2000 413 418
17. P. Nielsen R. Fischer P. Tondüry E.E. Gabbe G.E. Janka Liver iron stores in patients with posttransfusional siderosis under iron chelation with deferoxamine or deferiprone Brit. J. Haematol. 91 1995 827 833
18. R. Fischer C.D. Tiemann R. Engelhardt P. Nielsen M. Dürken E.E. Gabbe G.E. Janka The assessment of iron storage in children with transfusion siderosis by biomagnetic liver susceptometry Am. J. Hematol 60 1999 289 299
19. A. Asberg K. Hveem K. Thorstensen E. Ellekjter K. Kannelonning U. Fjosne T.B. Halvorsen H.B. Smethurst E. Sagen K.S. Bjerve Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons Scand. J. Gastroenterol. 36 2001 1108 1115
20. E. Beutler V.J. Felitti J.A. Koziol N.J. Ho T. Gelbart Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA Lancet 59 2002 211 218
21. Nielsen, P.2000Gendiagnostische Möglichkeiten der hereditären Hämochromatose. In Handbuch der molekularen Medizin Band 6. Ausgewählte monogen bedingte Erkrankungen, Teil 1, (Ganten, D., Ruckpaul, K., Eds.) pp. 454–475. Springer-Verlag, Berlin, Heidelberg.
22. C. Niederau R. Fischer A. Sonnenberg W. Stremmel H.J. Trampisch G. Strohmeyer Survival and causes of death in cirrhotic and non-cirrhotic patients with primary haemochromatosis N. Engl. J. Med. 313 1985 1256 1262
23. P. Arosio M. Yokota J.W. Drysdale Characterisation of serum ferritin in iron overload: Possible identity to natural apoferritin Brit. J. Haematol. 36 1977 199 207
24. S.J. Cragg M. Wagstaff M. Worwood Sialic acid and microheterogeneity of human serum ferritin Clin. Sci. 58 1980 259 262