A Pilot Study to Assess Markers of Renal Damage in the Rodent Kidney After Exposure to 7 MHz Ultrasound Pulse Sequences Designed to Cause Microbubble Translation and Disruption

Ultrasound in Medicine and Biology

Volumn 38, Issue 1, 2012, Pages 168-172

  Johnson, Kennita ^a   Cianciolo, Rachel ^b   Gessner, Ryan C ^a   Dayton, Paul A ^a  

^a Biomedical Research Imaging Center   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Bioeffects; Bjerknes force; Cavitation; Contrast agent; Microbubble; Radiation force

Indexed keywords

BIO-EFFECTS; BJERKNES FORCE; CONTRAST AGENT; MICROBUBBLE; RADIATION FORCE;

ACOUSTIC WAVE PROPAGATION; CAVITATION; DRUG DELIVERY;

ULTRASONICS;

ACOUSTICS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; KIDNEY INJURY; MALE; MICROBUBBLE; MICROBUBBLE DESTRUCTION; NONHUMAN; PILOT STUDY; PRIORITY JOURNAL; RADIATION FORCE; RADIOLOGICAL PROCEDURES; RAT; ULTRASOUND;

ACUTE KIDNEY INJURY; ANIMALS; CONTRAST MEDIA; HIGH-ENERGY SHOCK WAVES; KIDNEY; MALE; MICROBUBBLES; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 83055176282     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2011.10.001     Document Type: Article

References (32)

1. Carr C.L., Lindner J.R. Myocardial perfusion imaging with contrast echocardiography. Curr Cardiol Rep 2008, 10:233-239.
2. Caskey C.F., Qin S., Dayton P.A., Ferrara K.W. Microbubble tunneling in gel phantoms. J Acoust Soc Am 2009, 125:EL183-EL189.
3. Choi J.J., Wang S., Tung Y.S., Morrison B., Konofagou E.E. Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol 2010, 36:58-67.
4. Chomas J.E., Dayton P., May D., Ferrara K. Threshold of fragmentation for ultrasonic contrast agents. J Biomed Opt 2001, 6:141-150.
5. Cosgrove D., Lassau N. Imaging of perfusion using ultrasound. Eur J Nucl Med Mol Imaging 2008, 37(Suppl 1):S65-S85.
6. Dayton P.A., Morgan K.E., Klibanov A.L., Brandenburger G.H., Ferrara K.W. Optical and acoustical observations of the effects of ultrasound on contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 1999, 46:220-232.
7. Dayton P.A., Allen J.S., Ferrara K.W. The magnitude of radiation force on ultrasound contrast agents. J Acoust Soc Am 2002, 112:2183-2192.
8. Deelman L.E., Declèves A.-E., Rychak J.J., Sharma K. Targeted renal therapies through microbubbles and ultrasound. Adv Drug Deliv Rev 2010, 62:1369-1377.
9. Feingold S., Gessner R., Guracar I.M., Dayton P.A. Quantitative volumetric perfusion mapping of the microvasculature using contrast ultrasound. Invest Radiol 2010, 45:669-674.
10. Flynn H.G. Physics of acoustic cavitation in liquids. Physical acoustics, principles and methods 1B 1964, 57-172. Academic Press, New York, NY. W.P. Mason (Ed.).
11. Gessner R., Dayton P.A. Advances in molecular imaging with ultrasound. Mol Imaging 2010, 9:117-127.
12. Goldberg B., Raichlen J., Forsberg F. Ultrasound contrast agents: Basic brinicples and clinical applications 2001, Martin Dunitz Ltd., London. 2nd edition.
13. Hoeffel C., Mule S., Huwart L., Frouin F., Jais J.P., Helenon O., Correas J.M. Renal blood flow quantification in pigs using contrast-enhanced ultrasound: An ex vivo study. Ultraschall Med 2010, 31:363-369.
14. Lum A.F., Borden M.A., Dayton P.A., Kruse D.E., Simon S.I., Ferrara K.W. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release 2006, 111:128-134.
15. Mayer C.R., Geis N.A., Katus H.A., Bekeredjian R. Ultrasound targeted microbubble destruction for drug and gene delivery. Expert Opin Drug Deliv 2008, 5:1121-1138.
16. Miller D.L., Averkiou M.A., Brayman A.A., Everbach E.C., Holland C.K., Wible J.H., Wu J. Bioeffects considerations for diagnostic ultrasound contrast agents. J Ultrasound Med 2008, 27:611-632. quiz 33-36.
17. Miller D.L., Dou C., Wiggins R.C. Frequency dependence of kidney injury induced by contrast-aided diagnostic ultrasound in rats. Ultrasound Med Biol 2008, 34:1678-1687.
18. Miller D.L., Dou C., Wiggins R.C. Glomerular capillary hemorrhage induced in rats by diagnostic ultrasound with gas-body contrast agent produces intratubular obstruction. Ultrasound Med Biol 2009, 35:869-877.
19. Miller D.L., Dou C., Wiggins R.C. In vivo gas body efficacy for glomerular capillary hemorrhage induced by diagnostic ultrasound in rats. IEEE Trans Biomed Eng 2010, 57:167-174.
20. Patil A.V., Rychak J.J., Allen J.S., Klibanov A.L., Hossack J.A. Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels. Ultrasound Med Biol 2009, 35:2021-2030.
21. Phillips P., Gardner E. Contrast-agent detection and quantification. Eur Radiol 2004, 14(Suppl 8):P4-P10.
22. Pollard R.E., Dayton P.A., Watson K.D., Hu X.W., Guracar I.M., Ferrara K.W. Motion corrected cadence CPS ultrasound for quantifying response to vasoactive drugs in a rat kidney model. Urology 2009, 74:675-681.
23. Rychak J.J., Klibanov A.L., Ley K.F., Hossack J.A. Enhanced targeting of ultrasound contrast agents using acoustic radiation force. Ultrasound Med Biol 2007, 33:1132-1139.
24. Shortencarier M.J., Dayton P.A., Bloch S.H., Schumann P.A., Matsunaga T.O., Ferrara K.W. A method for radiation-force localized drug delivery using gas-filled lipospheres. IEEE Trans Ultrason Ferroelectr Freq Control 2004, 51:822-831.
25. Streeter J.E., Gessner R., Miles I., Dayton P.A. Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: In vivo studies. Mol Imaging 2010, 9:87-95.
26. Szabo T. Diagnostic ultrasound imaging: Inside out 2004, Elsevier, Burlington, MA.
27. Wible J.H., Galen K.P., Wojdyla J.K., Hughes M.S., Klibanov A.L., Brandenburger G.H. Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats. Ultrasound Med Biol 2002, 28:1535-1546.
28. Williams A.R., Wiggins R.C., Wharram B.L., Goyal M., Dou C., Johnson K.J., Miller D.L. Nephron injury induced by diagnostic ultrasound imaging at high mechanical index with gas body contrast agent. Ultrasound Med Biol 2007, 33:1336-1344.
29. Xiao J.D., Zhu W.H., Shen S.R. Evaluation of hepatocellular carcinoma using contrast-enhanced ultrasonography: Correlation with microvessel morphology. Hepatobiliary Pancreat Dis Int 2010, 9:605-610.
30. Zhang M., Fabiilli M.L., Haworth K.J., Padilla F., Swanson S.D., Kripfgans O.D., Carson P.L., Fowlkes J.B. Acoustic droplet vaporization for enhancement of thermal ablation by high-intensity focused ultrasound. Acad Radiol 2011, 18:1123-1132.
31. Zhao S., Borden M., Bloch S.H., Kruse D., Ferrara K.W., Dayton P.A. Radiation-force assisted targeting facilitates ultrasonic molecular imaging. Mol Imaging 2004, 3:135-148.
32. Zheng Z., Schmidt-Ott K.M., Chua S., Foster K.A., Frankel R.Z., Pavlidis P., Barasch J., D'Agati V.D., Gharavi A.G. A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc Nat Acad Sci USA 2005, 102:2502-2507.