메뉴 건너뛰기




Volumn 18, Issue 9, 2011, Pages 1123-1132

Acoustic Droplet Vaporization for Enhancement of Thermal Ablation by High Intensity Focused Ultrasound

Author keywords

In vivo; Microbubble; Minimally invasive therapy; Thermal lesion size; Ultrasound

Indexed keywords

WATER;

EID: 79960995553     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2011.04.012     Document Type: Article
Times cited : (94)

References (56)
  • 1
    • 63749101977 scopus 로고    scopus 로고
    • IARC Press, Lyon, France, P. Boyle, B. Levin (Eds.)
    • World cancer report 2008 2008, IARC Press, Lyon, France. P. Boyle, B. Levin (Eds.).
    • (2008) World cancer report 2008
  • 2
    • 0025738644 scopus 로고
    • Choice of treatments for small hepatocellular carcinoma: hepatectomy, embolization or ethanol injection
    • Yamasaki S., Hasegawa H., Makuuchi M., et al. Choice of treatments for small hepatocellular carcinoma: hepatectomy, embolization or ethanol injection. J Gastroenterol Hepatol 1991, 6:408-413.
    • (1991) J Gastroenterol Hepatol , vol.6 , pp. 408-413
    • Yamasaki, S.1    Hasegawa, H.2    Makuuchi, M.3
  • 3
    • 69249213440 scopus 로고    scopus 로고
    • Hepatic resection versus radiofrequency ablation for hepatocellular carcinoma in cirrhotic individuals not candidates for liver transplantation: a Markov model decision analysis
    • Molinari M., Helton S. Hepatic resection versus radiofrequency ablation for hepatocellular carcinoma in cirrhotic individuals not candidates for liver transplantation: a Markov model decision analysis. Am J Surg 2009, 198:396-406.
    • (2009) Am J Surg , vol.198 , pp. 396-406
    • Molinari, M.1    Helton, S.2
  • 4
    • 1442347508 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Atlanta, GA
    • Cancer facts and figures 2004, American Cancer Society, American Cancer Society, Atlanta, GA.
    • (2004) Cancer facts and figures
  • 5
    • 0029445004 scopus 로고
    • Review article: high intensity focused ultrasound-potential for cancer treatment
    • Hill C.R., ter Haar G.R. Review article: high intensity focused ultrasound-potential for cancer treatment. Br J Radiol 1995, 68:1296-1303.
    • (1995) Br J Radiol , vol.68 , pp. 1296-1303
    • Hill, C.R.1    ter Haar, G.R.2
  • 6
    • 39049103980 scopus 로고    scopus 로고
    • Applications of acoustics and cavitation to noninvasive therapy and drug delivery
    • Coussios C.C., Roy R.A. Applications of acoustics and cavitation to noninvasive therapy and drug delivery. Annu Rev Fluid Mech 2008, 40:395-420.
    • (2008) Annu Rev Fluid Mech , vol.40 , pp. 395-420
    • Coussios, C.C.1    Roy, R.A.2
  • 7
    • 33845416619 scopus 로고
    • A new method for the generation and use of focused ultrasound in experimental biology
    • Lynn J.G., Zwemer R.L., Chick A.J., et al. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol 1942, 26:179-193.
    • (1942) J Gen Physiol , vol.26 , pp. 179-193
    • Lynn, J.G.1    Zwemer, R.L.2    Chick, A.J.3
  • 8
    • 0000368962 scopus 로고
    • High-intensity ultrasonic vibrations for action on animal and human malignant tumours
    • Burov A.K. High-intensity ultrasonic vibrations for action on animal and human malignant tumours. Dokl Akad Nauk SSSR 1956, 106:239-241.
    • (1956) Dokl Akad Nauk SSSR , vol.106 , pp. 239-241
    • Burov, A.K.1
  • 9
    • 0018600264 scopus 로고
    • Ultrasonic attenuation and propagation speed in mammalian tissues as a function of temperature
    • Bamber J.C., Hill C.R. Ultrasonic attenuation and propagation speed in mammalian tissues as a function of temperature. Ultrasound Med Biol 1979, 5:149-157.
    • (1979) Ultrasound Med Biol , vol.5 , pp. 149-157
    • Bamber, J.C.1    Hill, C.R.2
  • 10
    • 0021077960 scopus 로고
    • Ultrasonic attenuation and absorption in liver tissue
    • Parker K.J. Ultrasonic attenuation and absorption in liver tissue. Ultrasound Med Biol 1983, 9:363-369.
    • (1983) Ultrasound Med Biol , vol.9 , pp. 363-369
    • Parker, K.J.1
  • 11
    • 0024070319 scopus 로고
    • Threshold dosages for damage to mammalian liver by high-intensity focused ultrasound
    • Frizzell L.A. Threshold dosages for damage to mammalian liver by high-intensity focused ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 1988, 35:578-581.
    • (1988) IEEE Trans Ultrason Ferroelectr Freq Control , vol.35 , pp. 578-581
    • Frizzell, L.A.1
  • 12
    • 0024407776 scopus 로고
    • High intensity focused ultrasound-a surgical technique for the treatment of discrete liver tumours
    • ter Haar G., Sinnett D., Rivens I. High intensity focused ultrasound-a surgical technique for the treatment of discrete liver tumours. Phys Med Biol 1989, 34:1743-1750.
    • (1989) Phys Med Biol , vol.34 , pp. 1743-1750
    • ter Haar, G.1    Sinnett, D.2    Rivens, I.3
  • 13
    • 33947118735 scopus 로고    scopus 로고
    • High intensity focused ultrasound: physical principles and devices
    • ter Haar G., Coussios C. High intensity focused ultrasound: physical principles and devices. Int J Hyperthermia 2007, 23:89-104.
    • (2007) Int J Hyperthermia , vol.23 , pp. 89-104
    • ter Haar, G.1    Coussios, C.2
  • 14
    • 0025329069 scopus 로고
    • Effects of physical parameters on high temperature ultrasound hyperthermia
    • Billard B.E., Hynynen K., Roemer R.B. Effects of physical parameters on high temperature ultrasound hyperthermia. Ultrasound Med Biol 1990, 16:409-420.
    • (1990) Ultrasound Med Biol , vol.16 , pp. 409-420
    • Billard, B.E.1    Hynynen, K.2    Roemer, R.B.3
  • 15
    • 0037727605 scopus 로고    scopus 로고
    • Renal radiofrequency ablation: clinical status 2003
    • Zelkovic P.F., Resnick M.I. Renal radiofrequency ablation: clinical status 2003. Curr Opin Urol 2003, 13:199-202.
    • (2003) Curr Opin Urol , vol.13 , pp. 199-202
    • Zelkovic, P.F.1    Resnick, M.I.2
  • 16
    • 0033910797 scopus 로고    scopus 로고
    • Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles
    • Chavrier F., Chapelon J.Y., Gelet A., et al. Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles. J Acoust Soc Am 2000, 108:432-440.
    • (2000) J Acoust Soc Am , vol.108 , pp. 432-440
    • Chavrier, F.1    Chapelon, J.Y.2    Gelet, A.3
  • 17
    • 20444501636 scopus 로고    scopus 로고
    • Hyperecho in ultrasound images of HIFU therapy: involvement of cavitation
    • Rabkin B.A., Zderic V., Vaezy S. Hyperecho in ultrasound images of HIFU therapy: involvement of cavitation. Ultrasound Med Biol 2005, 31:947-956.
    • (2005) Ultrasound Med Biol , vol.31 , pp. 947-956
    • Rabkin, B.A.1    Zderic, V.2    Vaezy, S.3
  • 18
    • 33947117433 scopus 로고    scopus 로고
    • Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU)
    • Coussios C.C., Farny C.H., Haar G.T., et al. Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU). Int J Hyperthermia 2007, 23:105-120.
    • (2007) Int J Hyperthermia , vol.23 , pp. 105-120
    • Coussios, C.C.1    Farny, C.H.2    Haar, G.T.3
  • 19
    • 76649128713 scopus 로고    scopus 로고
    • The correlation between bubble-enhanced HIFU heating and cavitation power
    • Farny C.H., Glynn Holt R., Roy R.A. The correlation between bubble-enhanced HIFU heating and cavitation power. IEEE Trans Biomed Eng 2010, 57:175-184.
    • (2010) IEEE Trans Biomed Eng , vol.57 , pp. 175-184
    • Farny, C.H.1    Glynn Holt, R.2    Roy, R.A.3
  • 20
    • 74849103216 scopus 로고    scopus 로고
    • Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound
    • Canney M.S., Khokhlova V.A., Bessonova O.V., et al. Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound. Ultrasound Med Biol 2010, 36:250-267.
    • (2010) Ultrasound Med Biol , vol.36 , pp. 250-267
    • Canney, M.S.1    Khokhlova, V.A.2    Bessonova, O.V.3
  • 21
    • 11144352197 scopus 로고    scopus 로고
    • Bubble dynamics and size distributions during focused ultrasound insonation
    • Yang X., Roy R.A., Holt R.G. Bubble dynamics and size distributions during focused ultrasound insonation. J Acoust Soc Am 2004, 116:3423-3431.
    • (2004) J Acoust Soc Am , vol.116 , pp. 3423-3431
    • Yang, X.1    Roy, R.A.2    Holt, R.G.3
  • 22
    • 76849101471 scopus 로고    scopus 로고
    • Cavitation and contrast: the use of bubbles in ultrasound imaging and therapy
    • Stride E.P., Coussios C.C. Cavitation and contrast: the use of bubbles in ultrasound imaging and therapy. Proc Inst Mech Eng H 2010, 224:171-191.
    • (2010) Proc Inst Mech Eng H , vol.224 , pp. 171-191
    • Stride, E.P.1    Coussios, C.C.2
  • 23
    • 74449091314 scopus 로고    scopus 로고
    • Dynamic changes of integrated backscatter, attenuation coefficient and bubble activities during high-intensity focused ultrasound (HIFU) treatment
    • Zhang S., Wan M., Zhong H., et al. Dynamic changes of integrated backscatter, attenuation coefficient and bubble activities during high-intensity focused ultrasound (HIFU) treatment. Ultrasound Med Biol 2009, 35:1828-1844.
    • (2009) Ultrasound Med Biol , vol.35 , pp. 1828-1844
    • Zhang, S.1    Wan, M.2    Zhong, H.3
  • 25
    • 33745586048 scopus 로고    scopus 로고
    • Contrast-agent-enhanced ultrasound thermal ablation
    • Tung Y.S., Liu H.L., Wu C.C., et al. Contrast-agent-enhanced ultrasound thermal ablation. Ultrasound Med Biol 2006, 32:1103-1110.
    • (2006) Ultrasound Med Biol , vol.32 , pp. 1103-1110
    • Tung, Y.S.1    Liu, H.L.2    Wu, C.C.3
  • 26
    • 0034281706 scopus 로고    scopus 로고
    • Acoustic droplet vaporization for therapeutic and diagnostic applications
    • Kripfgans O.D., Fowlkes J.B., Miller D.L., et al. Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol 2000, 26:1177-1189.
    • (2000) Ultrasound Med Biol , vol.26 , pp. 1177-1189
    • Kripfgans, O.D.1    Fowlkes, J.B.2    Miller, D.L.3
  • 27
    • 34547813763 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy
    • Rapoport N., Gao Z.G., Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J Natl Cancer Inst 2007, 99:1095-1106.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1095-1106
    • Rapoport, N.1    Gao, Z.G.2    Kennedy, A.3
  • 28
  • 29
    • 24944524212 scopus 로고    scopus 로고
    • Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: a kidney study
    • Kripfgans O.D., Orifici C.M., Carson P.L., et al. Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: a kidney study. IEEE Trans Ultras Ferroel Freq Control 2005, 52:1101-1110.
    • (2005) IEEE Trans Ultras Ferroel Freq Control , vol.52 , pp. 1101-1110
    • Kripfgans, O.D.1    Orifici, C.M.2    Carson, P.L.3
  • 30
    • 29144518427 scopus 로고    scopus 로고
    • Spatial control of gas bubbles and their effects on acoustic fields
    • Lo A.H., Kripfgans O.D., Carson P.L., et al. Spatial control of gas bubbles and their effects on acoustic fields. Ultrasound Med Biol 2006, 32:95-106.
    • (2006) Ultrasound Med Biol , vol.32 , pp. 95-106
    • Lo, A.H.1    Kripfgans, O.D.2    Carson, P.L.3
  • 31
    • 77956649393 scopus 로고    scopus 로고
    • Initial investigation of acoustic droplet vaporization for occlusion in canine kidney
    • Zhang M., Fabiilli M.L., Haworth K.J., et al. Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound Med Biol 2010, 36:1691-1703.
    • (2010) Ultrasound Med Biol , vol.36 , pp. 1691-1703
    • Zhang, M.1    Fabiilli, M.L.2    Haworth, K.J.3
  • 33
    • 77958154455 scopus 로고    scopus 로고
    • An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation
    • Zhang P., Porter T. An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation. Ultrasound Med Biol 2010, 36:1856-1866.
    • (2010) Ultrasound Med Biol , vol.36 , pp. 1856-1866
    • Zhang, P.1    Porter, T.2
  • 35
    • 9644310477 scopus 로고    scopus 로고
    • Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound
    • Takegami K., Kaneko Y., Watanabe T., et al. Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound. Ultrasound Med Biol 2004, 30:1419-1422.
    • (2004) Ultrasound Med Biol , vol.30 , pp. 1419-1422
    • Takegami, K.1    Kaneko, Y.2    Watanabe, T.3
  • 36
    • 0027998405 scopus 로고
    • Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes
    • Flaim S.F. Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes. Artif Cells Blood Substit Immobilization Biotechnol 1994, 22:1043-1054.
    • (1994) Artif Cells Blood Substit Immobilization Biotechnol , vol.22 , pp. 1043-1054
    • Flaim, S.F.1
  • 37
    • 0344731455 scopus 로고
    • Low-field nuclear magnetic resonance relaxation study of the thermal denaturation of transferrins
    • Lambelet P., Ducret F., Leuba J.L., et al. Low-field nuclear magnetic resonance relaxation study of the thermal denaturation of transferrins. J Agric Food Chem 1991, 39:287-292.
    • (1991) J Agric Food Chem , vol.39 , pp. 287-292
    • Lambelet, P.1    Ducret, F.2    Leuba, J.L.3
  • 38
    • 28544448874 scopus 로고    scopus 로고
    • Comparison of cryoablation, radiofrequency ablation and high-intensity focused ultrasound for treating small renal tumours
    • Weld K.J., Landman J. Comparison of cryoablation, radiofrequency ablation and high-intensity focused ultrasound for treating small renal tumours. BJU Int 2005, 96:1224-1229.
    • (2005) BJU Int , vol.96 , pp. 1224-1229
    • Weld, K.J.1    Landman, J.2
  • 39
    • 0035673103 scopus 로고    scopus 로고
    • Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material
    • Holt R.G., Roy R.A. Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol 2001, 27:1399-1412.
    • (2001) Ultrasound Med Biol , vol.27 , pp. 1399-1412
    • Holt, R.G.1    Roy, R.A.2
  • 40
    • 56949085275 scopus 로고    scopus 로고
    • Feasibility of using ultrasound contrast agents to increase the size of thermal lesions induced by non-focused transducers: in vitro demonstration in tissue mimicking phantom
    • Lafon C., Murillo-Rincon A., Goldenstedt C., et al. Feasibility of using ultrasound contrast agents to increase the size of thermal lesions induced by non-focused transducers: in vitro demonstration in tissue mimicking phantom. Ultrasonics 2009, 49:172-178.
    • (2009) Ultrasonics , vol.49 , pp. 172-178
    • Lafon, C.1    Murillo-Rincon, A.2    Goldenstedt, C.3
  • 41
    • 0003121707 scopus 로고
    • Effects of ultrasound on "solid" mammalian tissues and tumors in vivo
    • Plenum, New York, M.H. Repacholi, M. Grondolfo, A. Rindi (Eds.)
    • Lele P.P. Effects of ultrasound on "solid" mammalian tissues and tumors in vivo. Ultrasound: medical applications, biological effects and hazard potential 1987, 273-306. Plenum, New York. M.H. Repacholi, M. Grondolfo, A. Rindi (Eds.).
    • (1987) Ultrasound: medical applications, biological effects and hazard potential , pp. 273-306
    • Lele, P.P.1
  • 42
    • 0026090542 scopus 로고
    • The threshold for thermally significant cavitation in dog's thigh muscle in vivo
    • Hynynen K. The threshold for thermally significant cavitation in dog's thigh muscle in vivo. Ultrasound Med Biol 1991, 17:157-169.
    • (1991) Ultrasound Med Biol , vol.17 , pp. 157-169
    • Hynynen, K.1
  • 43
    • 0030975454 scopus 로고    scopus 로고
    • Temperature rise recorded during lesion formation by high-intensity focused ultrasound
    • Clarke R.L., ter Haar G.R. Temperature rise recorded during lesion formation by high-intensity focused ultrasound. Ultrasound Med Biol 1997, 23:299-306.
    • (1997) Ultrasound Med Biol , vol.23 , pp. 299-306
    • Clarke, R.L.1    ter Haar, G.R.2
  • 44
    • 79961000441 scopus 로고
    • National Council on Radiation Protection and Measurements, National Council on Radiation Protection and Measurements, Bethesda, MD
    • Exposure criteria for medical ultrasound. Part 1: exposure based on thermal mechanisms 1992, National Council on Radiation Protection and Measurements, National Council on Radiation Protection and Measurements, Bethesda, MD.
    • (1992) Exposure criteria for medical ultrasound. Part 1: exposure based on thermal mechanisms
  • 45
    • 37549059582 scopus 로고    scopus 로고
    • Prostate thermal therapy with high intensity transurethral ultrasound: the impact of pelvic bone heating on treatment delivery
    • Wootton J.H., Ross A.B., Diederich C.J. Prostate thermal therapy with high intensity transurethral ultrasound: the impact of pelvic bone heating on treatment delivery. Int J Hyperthermia 2007, 23:609-622.
    • (2007) Int J Hyperthermia , vol.23 , pp. 609-622
    • Wootton, J.H.1    Ross, A.B.2    Diederich, C.J.3
  • 47
    • 0026670045 scopus 로고
    • Response of the rabbit lung as a criterion of safety for fluorocarbon breathing and blood substitutes
    • Clark L.C., Hoffmann R.E., Davis S.L. Response of the rabbit lung as a criterion of safety for fluorocarbon breathing and blood substitutes. Biomater Artif Cells Immobilization Biotechnol 1992, 20:1085-1099.
    • (1992) Biomater Artif Cells Immobilization Biotechnol , vol.20 , pp. 1085-1099
    • Clark, L.C.1    Hoffmann, R.E.2    Davis, S.L.3
  • 48
    • 0028068141 scopus 로고
    • Proposed mechanism of pulmonary gas trapping (PGT) following intravenous perfluorocarbon emulsion administration
    • Schutt E., Barber P., Fields T., et al. Proposed mechanism of pulmonary gas trapping (PGT) following intravenous perfluorocarbon emulsion administration. Artif Cells Blood Substit Immobilization Biotechnol 1994, 22:1205-1214.
    • (1994) Artif Cells Blood Substit Immobilization Biotechnol , vol.22 , pp. 1205-1214
    • Schutt, E.1    Barber, P.2    Fields, T.3
  • 49
    • 0036210997 scopus 로고    scopus 로고
    • Radiofrequency coagulation of renal parenchyma: Comparison of effects of energy generators on treatment efficacy
    • Gettman M.T., Lotan Y., Corwin T.S., et al. Radiofrequency coagulation of renal parenchyma: Comparison of effects of energy generators on treatment efficacy. J Endourol 2002, 16:83-88.
    • (2002) J Endourol , vol.16 , pp. 83-88
    • Gettman, M.T.1    Lotan, Y.2    Corwin, T.S.3
  • 50
    • 39549120450 scopus 로고    scopus 로고
    • A novel approach to energy ablative therapy of small renal tumors: laparoscopic high-intensity focused ultrasound
    • Klingler H.C., Susani M., Seip R., et al. A novel approach to energy ablative therapy of small renal tumors: laparoscopic high-intensity focused ultrasound. Eur Urol 2008, 53:810-818.
    • (2008) Eur Urol , vol.53 , pp. 810-818
    • Klingler, H.C.1    Susani, M.2    Seip, R.3
  • 51
    • 67649743197 scopus 로고    scopus 로고
    • MR-guided focused ultrasound: a potentially disruptive technology
    • Bradley W.G. MR-guided focused ultrasound: a potentially disruptive technology. J Am Coll Radiol 2009, 6:510-513.
    • (2009) J Am Coll Radiol , vol.6 , pp. 510-513
    • Bradley, W.G.1
  • 52
    • 85024962344 scopus 로고    scopus 로고
    • Target localization for post-prostatectomy patients using CT and ultrasound image guidance
    • Paskalev K., Feigenberg S., Jacob R., et al. Target localization for post-prostatectomy patients using CT and ultrasound image guidance. J Appl Clin Medical Phys 2005, 6:40-49.
    • (2005) J Appl Clin Medical Phys , vol.6 , pp. 40-49
    • Paskalev, K.1    Feigenberg, S.2    Jacob, R.3
  • 54
    • 3142738089 scopus 로고    scopus 로고
    • On the acoustic vaporization of micrometer-sized droplets
    • Kripfgans O.D., Fabiilli M.L., Carson P.L., et al. On the acoustic vaporization of micrometer-sized droplets. J Acoust Soc Am 2004, 116:272-281.
    • (2004) J Acoust Soc Am , vol.116 , pp. 272-281
    • Kripfgans, O.D.1    Fabiilli, M.L.2    Carson, P.L.3
  • 55
    • 68149162624 scopus 로고    scopus 로고
    • Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry
    • Kohler M.O., Mougenot C., Quesson B., et al. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Med Phys 2009, 36:3521-3535.
    • (2009) Med Phys , vol.36 , pp. 3521-3535
    • Kohler, M.O.1    Mougenot, C.2    Quesson, B.3
  • 56
    • 77952094541 scopus 로고    scopus 로고
    • Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring
    • Terraz S., Cernicanu A., Lepetit-Coiffe M., et al. Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring. Eur Radiol 2010, 20:886-897.
    • (2010) Eur Radiol , vol.20 , pp. 886-897
    • Terraz, S.1    Cernicanu, A.2    Lepetit-Coiffe, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.