DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex

Biochemical and Biophysical Research Communications

Volumn 416, Issue 1-2, 2011, Pages 80-85

  Roy, Marc André ^a   D'Amours, Damien ^a  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

DNA repair; Genome integrity; Smc5 6 complex; Structural maintenance of chromosomes

Indexed keywords

DNA BINDING PROTEIN; DNA BINDING PROTEIN SMC5; DNA BINDING PROTEIN SMC6; NUCLEOTIDE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PURIFICATION;

CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA REPAIR; DNA, SINGLE-STRANDED; PROTEIN BINDING; RECOMBINATION, GENETIC; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 83055170634     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.149     Document Type: Article

References (27)

1. Hirano T. At the heart of the chromosome: SMC proteins in action. Nature Reviews Molecular Cell Biology 2006, 7:311-322.
2. Kegel A., Sjogren C. The Smc5/6 complex: more than repair?. Cold Spring Harbor Symposia on Quantitative Biology 2010, 75:179-187.
3. Anderson D.E., Losada A., Erickson H.P., Hirano T. Condensin and cohesin display different arm conformations with characteristic hinge angles. Journal of Cell Biology 2002, 156:419-424.
4. Yoshimura S.H., Hizume K., Murakami A., Sutani T., Takeyasu K., Yanagida M. Condensin architecture and interaction with DNA: regulatory non-SMC subunits bind to the head of SMC heterodimer. Current Biology 2002, 12:508-513.
5. Lehmann A.R., Walicka M., Griffiths D.J., Murray J.M., Watts F.Z., McCready S., Carr A.M. The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. Molecular and Cellular Biology 1995, 15:7067-7080.
6. Fousteri M.I., Lehmann A.R. A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein. EMBO Journal 2000, 19:1691-1702.
7. De Piccoli G., Torres-Rosell J., Aragon L. The unnamed complex: what do we know about Smc5-Smc6?. Chromosome Research 2009, 17:251-263.
8. Murray J.M., Carr A.M. Smc5/6: a link between DNA repair and unidirectional replication?. Nature Reviews Molecular Cell Biology 2008, 9:177-182.
9. Ivanov D., Nasmyth K. A topological interaction between cohesin rings and a circular minichromosome. Cell 2005, 122:849.
10. Cuylen S., Metz J., Haering C.H. Condensin structures chromosomal DNA through topological links. Nature Structural and Molecular Biology 2011, 18:894-901.
11. Torres-Rosell J., Machin F., Farmer S., Jarmuz A., Eydmann T., Dalgaard J.Z., Aragon L. SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nature Cell Biology 2005, 7:412-419.
12. Lindroos H.B., Strom L., Itoh T., Katou Y., Shirahige K., Sjogren C. Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Molecular Cell 2006, 22:755-767.
13. Tsuyama T., Inou K., Seki M., Seki T., Kumata Y., Kobayashi T., Kimura K., Hanaoka F., Enomoto T., Tada S. Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks. Biochemical and Biophysical Research Communications 2006, 351:935-939.
14. Pebernard S., Schaffer L., Campbell D., Head S.R., Boddy M.N. Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively. EMBO Journal 2008, 27:3011-3023.
15. Behlke-Steinert S., Touat-Todeschini L., Skoufias D.A., Margolis R.L. SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. Cell Cycle 2009, 8:2211-2218.
16. Roy M.A., Siddiqui N., D'Amours D. Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle 2011, 10:690-700.
17. St-Pierre J., Douziech M., Bazile F., Pascariu M., Bonneil E., Sauve V., Ratsima H., D'Amours D. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Molecular Cell 2009, 34:416-426.
18. Sergeant J., Taylor E., Palecek J., Fousteri M., Andrews E.A., Sweeney S., Shinagawa H., Watts F.Z., Lehmann A.R. Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex. Molecular and Cellular Biology 2005, 25:172-184.
19. Duan X., Yang Y., Chen Y.H., Arenz J., Rangi G.K., Zhao X., Ye H. Architecture of the Smc5/6 complex of Saccharomyces cerevisiae reveals a unique interaction between the Nse5-6 subcomplex and the hinge regions of Smc5 and Smc6. Journal of Biological Chemistry 2009, 284:8507-8515.
20. Ghaemmaghami S., Huh W.K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Global analysis of protein expression in yeast. Nature 2003, 425:737-741.
21. Stray J.E., Lindsley J.E. Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA. Journal of Biological Chemistry 2003, 278:26238-26248.
22. Hirano M., Hirano T. Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. EMBO Journal 2002, 21:5733-5744.
23. Wellinger R.J., Wolf A.J., Zakian V.A. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 1993, 72:51-60.
24. Sogo J.M., Lopes M., Foiani M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 2002, 297:599-602.
25. Huertas P. DNA resection in eukaryotes: deciding how to fix the break. Nature Structural and Molecular Biology 2010, 17:11-16.
26. Torres-Rosell J., Sunjevaric I., De Piccoli G., Sacher M., Eckert-Boulet N., Reid R., Jentsch S., Rothstein R., Aragon L., Lisby M. The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nature Cell Biology 2007, 9:923-931.
27. Chiolo I., Minoda A., Colmenares S.U., Polyzos A., Costes S.V., Karpen G.H. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 2011, 144:732-744.