Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant

Journal of Neuroscience

Volumn 31, Issue 49, 2011, Pages 18180-18184

  Erk, Susanne ^a   Meyer Lindenberg, Andreas ^c   von Boberfeld, Carola Opitz ^b   Esslinger, Christine ^g   Schnell, Knut ^h   Kirsch, Peter ^f   Mattheisen, Manuel ^d,j   Mühleisen, Thomas W ^d,e   Cichon, Sven ^d,e,i   Witt, Stephanie H ^c   Rietschel, Marcella ^c   Nöthen, Markus M ^d,e   Walter, Henrik ^a,b,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Division of Medical Psychology   (Germany)

^c Department of Psychiatry and Psychotherapy ^*  (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e Institute of Human Genetics   (Germany)

^f CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^g OTTO VON GUERICKE UNIVERSITY   (Germany)

^h UNIVERSITY OF HEIDELBERG   (Germany)

ⁱ FORSCHUNGSZENTRUM JÜLICH   (Germany)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALZHEIMER DISEASE; ARTICLE; CLU GENE; EPISODIC MEMORY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RISK;

ADULT; BRAIN MAPPING; CLUSTERIN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OXYGEN; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; YOUNG ADULT;

EID: 83055169156     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4960-11.2011     Document Type: Article

References (33)

1. Allen G, Barnard H, McColl R, Hester AL, Fields JA, Weiner MF, Ringe WK, Lipton AM, Brooker M, McDonald E, Rubin CD, Cullum CM (2007) Reduced hippocampal functional connectivity in Alzheimer disease. Arch Neurol 64:1482-1487.
2. Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Yuan Y, Zang Y, Zhu C, Qian Y (2009) Abnormal functional connectivity of hippocampus during episodic memory retrieval processing network in amnestic mild cognitive impairment. Biol Psychiatry 65:951-958.
3. Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV (2007) Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 27:909-918.
4. Bertram L, Tanzi RE (2010) Alzheimer disease: new light on an old CLU. Nat Rev Neurol 6:11-13.
5. Bookheimer S, Burggren A (2009) APOE-4 genotype and neurophysiologi-cal vulnerability to Alzheimer's and cognitive aging. Annu Rev Clin Psy-chol 5:343-362.
6. Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubi-caray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM (2011) Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci 31:6764-6770.
7. Burgess PW, Shallice T (1996) Confabulation and the control of recollection. Memory 4:359-411.
8. Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG (2010) ReplicationofCLU, CR1, and PICALM associations with Alzheimer disease. Arch Neurol 67:961-964.
9. Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, et al. (2010) Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologi-cally verified individuals. Hum Mol Genet 19:3295-3301.
10. Dickerson BC, Sperling RA (2008) Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia 46:1624-1635.
11. Erk S, Meyer-Lindenberg A, Schnell K, Opitz von Boberfeld C, Esslinger C, Kirsch P, Grimm O, Arnold C, Haddad L, Witt SH, Cichon S, Nöthen MM, Rietschel M, Walter H (2010) Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatry 67:803-811.
12. Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F (2011) Evidence for neuronal compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry 68:845-852.
13. Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Arnold C, Haddad L, Mier D, Opitz von Boberfeld C, Raab K, Witt SH, Rietschel M, Cichon S, Meyer-Lindenberg A (2009) Neural mechanisms of a genome-wide supported psychosis variant. Science 324:605.
14. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO (1989) Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 262:2551-2556.
15. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349-1356.
16. Frankland PW, Bontempi B (2005) The organization of recent and remote memories. Nat Rev Neurosci 6:119-130.
17. Friedman L, Glover GH (2006) Report on a multicenter fMRI quality assurance protocol. J Magn Reson Imaging 23:827-839.
18. Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL (2006) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63:168-174.
19. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI (2001) Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 124:739-756.
20. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, et al. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41:1088-1093.
21. Honea RA, Vidoni E, Harsha A, Burns JM (2009) Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study. J Alzheimers Dis 18:553-564.
22. Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, StGeorge-Hyslop P, St George-Hyslop P, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, et al. (2010) Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 67:1473-1484.
23. Kamboh MI, Minster RL, Demirci FY, Ganguli M, Dekosky ST, Lopez OL, Barmada MM (2010) Association of CLU and PICALM variants with Alzheimer's disease. Neurobiol Aging. Advance online publication. Retrieved June 2010. doi:10.1016/j.neurobiolaging.2010.04.015.
24. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combar-ros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41:1094-1099.
25. Lancaster TM, Baird A, Wolf C, Jackson MC, Johnston SJ, Donev R, Thome J, Linden DE (2011) Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene. Eur Neuropsychopharmacol. Advance online publication. Retrieved March 2011. doi:10.1016/j.euroneuro.2011.02.001.
26. Meyer-Lindenberg A (2009) Neural connectivity as an intermediate phenotype: brain networks under genetic control. Hum Brain Mapp 30:1938-1946.
27. Meyer-Lindenberg A, Weinberger DR (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7:818-827.
28. Rempel-Clower NL, Barbas H (2000) The laminar pattern of connections between prefrontal and anterior temporal cortices in the Rhesus monkey is related to cortical structure and function. Cereb Cortex 10:851-865.
29. Schacter DL, Alpert NM, Savage CR, Rauch SL, Albert MS (1996) Conscious recollection and the human hippocampal formation: evidence from positron emission tomography. Proc Natl Acad Sci U S A 93:321-325.
30. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT Jr, Janssens AC, Pank-ratz VS, Dartigues JF, Hollingworth P, Aspelund T, et al. (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. Jama 303:1832-1840.
31. Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D'Angelo G, Liu C, Dixit S, Benzinger T, Fagan A, Goate A, Mintun MA (2010) APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Abeta42. J Neurosci 30:17035-17040.
32. Simons JS, Spiers HJ (2003) Prefrontal and medial temporal lobe interactions in long-term memory. Nat Rev Neurosci 4:637-648.
33. Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C (2010) The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends Genet 26:84-93.