Enhancement of solubility and dissolution property of griseofulvin by nanocrystallization

International Journal of Drug Development and Research

Volumn 3, Issue 2, 2011, Pages 180-191

  Dandagi, Phanchaxari M ^a   Kaushik, Sumit ^a   Telsang, Shaktish ^a  

^a K L E S S COLLEGE OF PHARMACY   (India)

Author keywords

Bioavailability; Dissolution velocity; Griseofulvin; Nanocrystallization; Nanocrystals; Stabilizers

Indexed keywords

BETA CYCLODEXTRIN; GRISEOFULVIN; NANOCRYSTAL;

ARTICLE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; ENVIRONMENTAL TEMPERATURE; PARTICLE SIZE; THERMOSTABILITY; X RAY DIFFRACTION;

EID: 83055163472     PISSN: None     EISSN: 09759344     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Hecq J, Deleers M, Fanara D, Vranckx H, Amighi K. Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. Int J Pharm 2005; 299:167-77.
2. E. Merisko-Liversidge, Nanocrystals: Resolving pharmaceutical formulation issues associated with poorly water-soluble compounds. Paper 45. Particles 2002 April 20-23;Orlando, Florida.
3. Loftsson T, Hreinsdottir D, Masson M. Evaluation of cyclodextrin solubilization of drugs. Int J pharm. 2005; 302:18-28.
4. Loftsson T. Cyclodextrins and the biopharmaceutics classification system of drugs. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2002;44: 637.
5. Hu LD, Tang X, Cui FD. Solid lipid nanoparticles to improve oral bioavailability of poorly soluble drugs. JPP.2004; 15:1527-35.
6. Akkar A, Namsolleck P, Blaut M, Rainer H, Muller. Solubilizing poorly soluble antimitotic agents by emulsification via a solvent free process. AAPS Pahrm Sci Tech 2004; 5(1):1-6.
7. Busharb FM, Muller RH. Nanocrystals of poorly soluble drugs for oral administration. NewDrugs:20-3. Available form: URL:URL http://userpage.fuberlin.de/~mpharm2/Download/pdf/Nanopure.pdf
8. Gao L, Zhang D, Chen M. Drug nanocrystal for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 2008; 10:845-62.
9. Makhlof A, Miyazaki Y, Tozuka Y, Takeuchi H. Cyclodextrins as stabilizers for the preparation of drug nanocrystals by the emulsion solvent diffusion method. Int J Pharm. 2008; 357:280-5.
10. Eerdenburgh BV, Mooter GV, Augustijins P. Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products. Int Jpharm. 2008; 363:64-75.
11. Vyas SP, Khar RK. 2008. Targeted & controlled drug delivery, Novel carrier system. New Delhi, India: CBS publishers & distributors;. p. 344.
12. Waard H, Hinrichs WLJ, Frijlink HW. A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying. J Control Rel. 2008;128:179-83.
13. Tripathi KD. 2008. Essentials of medical pharmacology. New Delhi, India: Jaypee Brothers, Medical publishers (p) Ltd;. p. 760-1.
14. Buckton, G, Beezer, AE. The relationship between particle size and solubility. Int. J. Pharm. 1992; 82:R7-R10.
15. Wenju W, Nancollas, GH. A new understanding of the relationship between solubility and particle size. J. Solution Chem. 1998;27:521-31.
16. Prasad et al. Method of delivering hydrophobic drug via nanocrystal. 2007; United States Patent 0134340.
17. Balakrishnan A, Rege BD, Amidon GL, Polli JE. Surfactant mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity. J Pharm Sci. 2004; 93(8):2064-75.
18. Müller R.H, Akkar A. 2004. Drug nanocrystals of poorly soluble drugs. In: Nalwa, H.S. (Ed.), Encyclopedia of Nanoscience and Nanotechnology. New York: American Scientific Publishers, p. 627-38.