Altered pain responses in abstinent (±)3,4- methylenedioxymethamphetamine (MDMA, "ecstasy") users

Psychopharmacology

Volumn 217, Issue 4, 2011, Pages 475-484

  Mccann, Una D ^a   Edwards, Robert R ^a,b   Smith, Michael T ^a   Kelley, Kristen ^a   Wilson, Michael ^a   Sgambati, Francis ^a   Ricaurte, George ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

MDMA; Neurotoxicity; Pain; Power spectra; Serotonin; Sleep

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; CANNABIS; COCAINE; OPIATE; PSYCHEDELIC AGENT; SEROTONIN;

ADULT; AGE DISTRIBUTION; ARTICLE; COLD PRESSOR TEST; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MECHANICAL STIMULATION; NEUROTOXICITY; NOCICEPTION; NOCICEPTIVE STIMULATION; NONREM SLEEP; NORMAL HUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; REM SLEEP; SLEEP; THERMAL STIMULATION; TOBACCO;

ADULT; BRAIN; FEMALE; HUMANS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROPSYCHOLOGICAL TESTS; NEUROTOXICITY SYNDROMES; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; REGRESSION ANALYSIS; SEROTONIN; SLEEP; SUBSTANCE WITHDRAWAL SYNDROME; YOUNG ADULT;

EID: 82955249229     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2303-7     Document Type: Article

References (56)

1. Aira Z, Buesa I, Salgueiro M, Bilbao J, Aguilera L, Zimmermann M et al (2010) Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience 168:831-841
2. Allen RP, McCann UD, Ricaurte GA (1993) Persistent effects of (+/?) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on human sleep. Sleep 16:560-564 (Pubitemid 23286946)
3. Bair MJ, Wu J, Damush TM, Sutherland JM, Kroenke K (2008) Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom Med 70:890-897
4. Borbely AA (2009) Refining sleep homeostasis in the two-process model. J Sleep Res 18:1-2
5. Buchert R, Thomasius R, Nebeling B, Petersen K, Obrocki J, Jenicke L et al (2003) Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PET. J Nucl Med 44:375-384 (Pubitemid 39586013)
6. Buchert R, Thomasius R, Wilke F, Petersen K, Nebeling B, Obrocki J et al (2004) A voxel-based PET investigation of the long-term effects of "Ecstasy" consumption on brain serotonin transporters. Am J Psychiatry 161:1181-1189 (Pubitemid 38859166)
7. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R (2006) Frequency of headache is related to sensitization: a population study. Pain 123:19-27 (Pubitemid 43833335)
8. Chitour D, Dickenson AH, Le Bars D (1982) Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Res 236 (2):329-337 (Pubitemid 12132555)
9. Curran HV, Travill RA (1997) Mood and cognitive effects of +/?3,4- methylenedioxymethamphetamine (MDMA, 'ecstasy'): weekend 'high' followed by mid-week low. Addiction 92:821-831 (Pubitemid 27326235)
10. Edwards RR (2005) Individual differences in endogenous pain modulation as a risk factor for chronic pain. Neurology 65:437-443 (Pubitemid 41099808)
11. Edwards RR, Almeida DM, Klick B, Haythornthwaite JA, Smith MT (2008) Duration of sleep contributes to next-day pain report in the general population. Pain 137:202-207
12. Edwards RR, Fillingim RB (2001) Effects of age on temporal summation and habituation of thermal pain: clinical relevance in healthy older and younger adults. J Pain 2:307-317 (Pubitemid 34042405)
13. Edwards RR, Fillingim RB, Ness TJ (2003) Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults. Pain 101:155-165 (Pubitemid 36044663)
14. Edwards RR, Grace E, Peterson S, Klick B, Haythornthwaite JA, Smith MT (2009) Sleep continuity and architecture: associations with pain-inhibitory processes in patients with temporomandibular joint disorder. Eur J Pain 13:1043-1047
15. Edwards RR, Haythornthwaite JA, Sullivan MJ, Fillingim RB (2004) Catastrophizing as a mediator of sex differences in pain: differential effects for daily pain versus laboratory-induced pain. Pain 111:335-341 (Pubitemid 39201155)
16. Edwards RR, Sarlani E, Wesselmann U, Fillingim RB (2005) Quantitative assessment of experimental pain perception: multiple domains of clinical relevance. Pain 114:315-319 (Pubitemid 40385870)
17. El-Mallakh RS, Abraham HD (2007) MDMA (Ecstasy). Ann Clin Psychiatry 19:45-52 (Pubitemid 46439721)
18. Feinberg I, Floyd TC (1979) Systematic trends across the night in human sleep cycles. Psychophysiology 16:283-291 (Pubitemid 9186348)
19. First MB, Spitzer RL, Gibbon M, Williams JB (2002) Structured clinical interview for DSM-IV axis I Disorders (SCID-I), Clinician Version.
20. Fischer C, Hatzidimitriou G, Wlos J, Katz J, Ricaurte G (1995) Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/?)3,4- methylenedioxymethamphetamine (MDMA, "ecstasy"). JNeurosci 15:5476-5485
21. GerraG, ZaimovicA, FerriM, Zambelli U, TimpanoM,Neri E et al (2000) Long-lasting effects of (+/?)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans. Biol Psychiatry 47:127-136
22. Gudelsky GA, Yamamoto BK (2008) Actions of 3,4- methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacol Biochem Behav 90:198-207 (Pubitemid 351787346)
23. Hatzidimitriou G, McCann UD, Ricaurte GA (1999) Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/?)3,4-methylenedioxymethamphetamine 7 years previously: factors influencing abnormal recovery. J Neurosci 19:5096-5107 (Pubitemid 29270144)
24. Iber C, Ancoli-Israel S, Chesson AL, Quan SF (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specifications.
25. Kalechstein AD, De La Garza R II, Mahoney JJ III, Fantegrossi WE, Newton TF (2007) MDMA use and neurocognition: a metaanalytic review. Psychopharmacology (Berl) 189:531-537 (Pubitemid 44791222)
26. Kosek E, Hansson P (1997) Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 70:41-51 (Pubitemid 27128296)
27. Lopez-Garcia JA (2006) Serotonergic modulation of spinal sensory circuits. Curr Top Med Chem 6:1987-1996 (Pubitemid 44524472)
28. Malemud CJ (2009) Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome. Clin Exp Rheumatol 27:S86-S91
29. McCann UD, Eligulashvili V, Mertl M, Murphy DL, Ricaurte GA (1999) Altered neuroendocrine and behavioral responses to mchlorophenylpiperazine in 3,4-methylenedioxymethamphetamine(MDMA) users. Psychopharmacology (Berl) 147:56-65 (Pubitemid 30010024)
30. McCann UD, Ridenour A, Shaham Y, Ricaurte GA (1994) Serotonin neurotoxicity after (+/?) 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans. Neuropsychopharmacology 10:129-138
31. McCann UD, Szabo Z, Scheffel U, Dannals RF, Ricaurte GA (1998) Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. Lancet 352:1433-1437 (Pubitemid 28510877)
32. McCann UD, Szabo Z, Seckin E, Rosenblatt P, Mathews WB, Ravert HT et al (2005) Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB. Neuropsychopharmacology 30:1741-1750 (Pubitemid 43086031)
33. McCann UD, Ricaurte GA (2007) Effects of (+/?) 3,4- methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythms. Sci World J 7:231-238 (Pubitemid 350277584)
34. McCann UD, Peterson SC, Ricaurte GA (2007) The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users. Neuropsychopharmacology 32:1695-1706 (Pubitemid 47076382)
35. McCann UD, Szabo Z, Vranesic M, Palermo M, Mathews WB, Ravert HT et al (2008) Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/?) 3,4- methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance. Psychopharmacology (Berl) 200:439-450
36. McCann UD, Wilson MJ, Sgambati FP, Ricaurte GA (2009a) Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users. J Neurosci 29(44):14050-14056
37. McCann UD, Sgambati FP, Schwartz AR, Ricaurte GA (2009b) Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers. Neurology 73(23):2011-2017
38. Morgan MJ (2000) Ecstasy (MDMA) a review of its possible persistent psychological effects. Psychopharmacology (Berl) 152:230-248
39. Murillo-Rodriguez E, Arias-Carrion O, Sanguino-Rodriguez K, Gonzalez-Arias M, Haro R (2009) Mechanisms of sleep-wake cycle modulation. CNS Neurol Disord Drug Targets 8:245-253
40. O'Hearn E, Battaglia G, De Souza E, Kuhar M, Molliver M (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788-2803
41. O'Regan MC, Clow A (2004) Decreased pain tolerance and mood in recreational users of MDMA. Psychopharmacology (Berl) 173:446-451 (Pubitemid 38703821)
42. Parrott AC (2000) Human research on MDMA (3,4- methylenedioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change. Neuropsychobiology 42:17-24 (Pubitemid 30436312)
43. Randall S, Johanson CE, Tancer M, Roehrs T (2009) Effects of acute 3,4-methylenedioxymethamphetamine on sleep and daytime sleepiness in MDMA users: a preliminary study. Sleep 32 (11):1513-1519
44. Reneman L, Booij J, de Bruin K, Reitsma JB, de Wolff FA, Gunning WB et al (2001) Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. Lancet 358:1864-1869 (Pubitemid 34008653)
45. Semple DM, Ebmeier KP, Glabus MF, O'Carroll RE, Johnstone EC (1999) Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users. Br J Psychiatry 175:63-69 (Pubitemid 29307857)
46. Smith MT, Edwards RR, McCann UD, Haythornthwaite JA (2007) The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 30:494-505 (Pubitemid 46668707)
47. Staud R, Robinson ME, Vierck CJ Jr, Cannon RC, Mauderli AP, Price DD (2003) Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome. Pain 105:215-222 (Pubitemid 37162491)
48. Talbot JD, Duncan GH, Bushnell MC (1989) Effects of diffuse noxious inhibitory controls (DNICs) on the sensory-discriminative dimension of pain perception. Pain 36:231-238 (Pubitemid 19045583)
49. Thomasius R, Zapletalova P, Petersen K, Buchert R, Andresen B, Wartberg L et al (2006) Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. J Psychopharmacol 20:211-225
50. Tiede W, Magerl W, Baumgartner U, Durrer B, Ehlert U, Treede RD (2010) Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers. Pain 148:36-42
51. Verkes RJ, Gijsman HJ, Pieters MS, Schoemaker RC, de Visser S, Kuijpers M et al (2001) Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology (Berl) 153:196-202 (Pubitemid 32127887)
52. Woodrow KM, Friedman GD, Siegelaub AB, Collen MF (1972) Pain tolerance: differences according to age, sex and race. Psychosom Med 34:548-556
53. Wu LT, Parrott AC, Ringwalt CL, Yang C, Blazer DG (2009) The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions. Am J Addict 18:452-461
54. Yoshimura M, Furue H (2006) Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. J Pharmacol Sci 101:107-117 (Pubitemid 43938761)
55. Zakzanis KK, Campbell Z, Jovanovski D (2007) The neuropsychology of ecstasy (MDMA) use: a quantitative review. Hum Psychopharmacol 22:427-435 (Pubitemid 47611297)
56. Zhang L, Samet J, Caffo B, Bankman I, Punjabi NM (2008) Power spectral analysis of EEG activity during sleep in cigarette smokers. Chest 133:427-432 (Pubitemid 351272401)