Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

Arthritis Research and Therapy

Volumn 13, Issue 6, 2011, Pages

  Hu, Nan ^a   Westra, Johanna ^a   Rutgers, Abraham ^a   Doornbos Van der Meer, Berber ^a   Huitema, Minke G ^a   Stegeman, Coen A ^a   Abdulahad, Wayel H ^a   Satchell, Simon C ^b   Mathieson, Peter W ^b   Heeringa, Peter ^a   M Kallenberg, Cees G ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; REPARIXIN; TUMOR NECROSIS FACTOR ALPHA; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ARTICLE; BLOOD VESSEL WALL; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLOMERULUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MALE; NEUTROPHIL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; BLOOD; CELL ADHESION; CELL CULTURE; CELL LINE; CELL MEMBRANE; CELL MOTION; DOSE RESPONSE; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; VASCULITIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NEUTROPHILS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS;

EID: 82955246727     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3534     Document Type: Article

References (47)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med 1997, 337:1512-1523. 10.1056/NEJM199711203372106, 9366584.
2. Kallenberg CG, Heeringa P, Stegeman CA. Mechanisms of disease: pathogenesis and treatment of ANCA-associated vasculitides. Nat Clin Pract Rheumatol 2006, 2:661-670. 10.1038/ncprheum0355, 17133251.
3. Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990, 87:4115-4119. 10.1073/pnas.87.11.4115, 54058, 2161532.
4. Savage CO, Pottinger BE, Gaskin G, Pusey CD, Pearson JD. Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 1992, 141:335-342. 1886603, 1323218.
5. Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Maeda N, Falk RJ, Jennette JC. The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 2005, 167:39-45. 10.1016/S0002-9440(10)62951-3, 1603451, 15972950.
6. Murphy PM. Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin Hematol 1997, 34:311-318.
7. Pham CT. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol 2006, 6:541-550. 10.1038/nri1841, 16799473.
8. Abdel-Salam B, Iking-Konert C, Schneider M, Andrassy K, Hansch GM. Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood. Kidney Int 2004, 66:1009-1017. 10.1111/j.1523-1755.2004.00849.x, 15327394.
9. Brachemi S, Mambole A, Fakhouri F, Mouthon L, Guillevin L, Lesavre P, Halbwachs-Mecarelli L. Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies. J Am Soc Nephrol 2007, 18:2330-2339. 10.1681/ASN.2006121309, 17634439.
10. Reumaux D, Vossebeld PJ, Roos D, Verhoeven AJ. Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood 1995, 86:3189-3195.
11. Van Rossum AP, Van Der Geld YM, Limburg PC, Kallenberg CG. Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils. Kidney Int 2005, 68:537-541. 10.1111/j.1523-1755.2005.00431.x, 16014030.
12. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994, 37:187-192. 10.1002/art.1780370206, 8129773.
13. Satchell SC, Tasman CH, Singh A, Ni L, Geelen J, von Ruhland CJ, O'Hare MJ, Saleem MA, van den Heuvel LP, Mathieson PW. Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF. Kidney Int 2006, 69:1633-1640. 10.1038/sj.ki.5000277, 16557232.
14. Hu N, Westra J, Huitema MG, Bijl M, Brouwer E, Stegeman CA, Heeringa P, Limburg PC, Kallenberg CG. Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils. Arthritis Rheum 2009, 60:1548-1557. 10.1002/art.24442, 19404956.
15. Louis NA, Campbell E, Colgan SP. Model systems to investigate neutrophil adhesion and chemotaxis. Neutrophil methods and protocols 2007, 257-272. Totowa: Humana Press, Quinn MT, Deleo FR, Bokoch GM.
16. Zouki C, Beauchamp M, Baron C, Filep JG. Prevention of in vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein. J Clin Invest 1997, 100:522-529. 10.1172/JCI119561, 508218, 9239398.
17. Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E, Martinez FO, Di Bitondo R, Troiani G, Sabbatini V, D'Anniballe G, Anacardio R, Cutrin JC, Cavalieri B, Mainiero F, Strippoli R, Villa P, Di Girolamo M, Martin F, Gentile M, Santoni A, Corda D, Poli G, Mantovani A, Ghezzi P, Colotta F. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci USA 2004, 101:11791-11796. 10.1073/pnas.0402090101, 511013, 15282370.
18. Westra J, Brouwer E, van Roosmalen IA, Doornbos-van der Meer B, van Leeuwen MA, Posthumus MD, Kallenberg CG. Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor. BMC Musculoskelet Disord 2010, 11:61. 10.1186/1471-2474-11-61, 2851671, 20353560.
19. Jonasdottir O, Petersen J, Bendtzen K. Tumour necrosis factor-alpha (TNF), lymphotoxin and TNF receptor levels in serum from patients with Wegener's granulomatosis. APMIS 2001, 109:781-786. 10.1034/j.1600-0463.2001.d01-146.x, 11900058.
20. Ohlsson S, Wieslander J, Segelmark M. Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?. Mediators Inflamm 2004, 13:275-283. 10.1080/09629350400003100, 1781567, 15545059.
21. Tesar V, Masek Z, Rychlik I, Merta M, Bartunkova J, Stejskalova A, Zabka J, Janatkova I, Fucikova T, Dostal C, Becvar R. Cytokines and adhesion molecules in renal vasculitis and lupus nephritis. Nephrol Dial Transplant 1998, 13:1662-1667. 10.1093/ndt/13.7.1662, 9681708.
22. Kumpers P, Hellpap J, David S, Horn R, Leitolf H, Haller H, Haubitz M. Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement. Nephrol Dial Transplant 2009, 24:1845-1850. 10.1093/ndt/gfn755, 19164323.
23. Lemieux C, Maliba R, Favier J, Theoret JF, Merhi Y, Sirois MG. Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood 2005, 105:1523-1530. 10.1182/blood-2004-09-3531, 15498854.
24. Bauer S, Abdgawad M, Gunnarsson L, Segelmark M, Tapper H, Hellmark T. Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol 2007, 81:458-464. 10.1189/jlb.0806514, 17077162.
25. Rose JJ, Foley JF, Murphy PM, Venkatesan S. On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2. J Biol Chem 2004, 279:24372-24386. 10.1074/jbc.M401364200, 15028716.
26. van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P. Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin Exp Immunol 2009, 158:143-153. 10.1111/j.1365-2249.2009.03993.x, 2759069, 19737241.
27. Godaly G, Hang L, Frendeus B, Svanborg C. Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice. J Immunol 2000, 165:5287-5294.
28. Mintz R, Garty BZ, Meshel T, Marcus N, Katanov C, Cohen-Hillel E, Ben Baruch A. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. Immunol Lett 2010, 130:97-106. 10.1016/j.imlet.2009.12.006, 20005258.
29. Olszyna DP, Florquin S, Sewnath M, Branger J, Speelman P, van Deventer SJ, Strieter RM, van der Poll T. CXC chemokine receptor 2 contributes to host defense in murine urinary tract infection. J Infect Dis 2001, 184:301-307. 10.1086/322030, 11443555.
30. Slocombe RF, Malark J, Ingersoll R, Derksen FJ, Robinson NE. Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves. Am J Vet Res 1985, 46:2253-2258.
31. Svensson M, Irjala H, Svanborg C, Godaly G. Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection. Kidney Int 2008, 74:81-90. 10.1038/ki.2008.105, 18401338.
32. Muller Kobold AC, Mesander G, Stegeman CA, Kallenberg CG, Tervaert JW. Are circulating neutrophils intravascularly activated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides?. Clin Exp Immunol 1998, 114:491-499. 10.1046/j.1365-2249.1998.00748.x, 1905131, 9844062.
33. Casilli F, Bianchini A, Gloaguen I, Biordi L, Alesse E, Festuccia C, Cavalieri B, Strippoli R, Cervellera MN, Di Bitondo R, Ferretti E, Mainiero F, Bizzarri C, Colotta F, Bertini R. Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2. Biochem Pharmacol 2005, 69:385-394. 10.1016/j.bcp.2004.10.007, 15652230.
34. Cohen-Hillel E, Yron I, Meshel T, Ben Baruch A. Interleukin 8 and cell migration to inflammatory sites: the regulation of focal adhesion kinase under conditions of migratory desensitization. Isr Med Assoc J 2007, 9:579-583.
35. Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum 2008, 58:2329-2337. 10.1002/art.23622, 18668539.
36. Savage CO, Brooks CJ, Adu D, Richards G, Howie AJ. Cell adhesion molecule expression within human glomerular and kidney organ culture. J Pathol 1997, 181:111-115. 10.1002/(SICI)1096-9896(199701)181:1<111::AID-PATH698>3.0.CO;2-9, 9072012.
37. Lally F, Smith E, Filer A, Stone MA, Shaw JS, Nash GB, Buckley CD, Rainger GE. A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum 2005, 52:3460-3469. 10.1002/art.21394, 3119436, 16255036.
38. Hechtman DH, Cybulsky MI, Fuchs HJ, Baker JB, Gimbrone MA. Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol 1991, 147:883-892.
39. Simonet WS, Hughes TM, Nguyen HQ, Trebasky LD, Danilenko DM, Medlock ES. Long-term impaired neutrophil migration in mice overexpressing human interleukin-8. J Clin Invest 1994, 94:1310-1319. 10.1172/JCI117450, 295217, 7521886.
40. Cockwell P, Brooks CJ, Adu D, Savage CO. Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. Kidney Int 1999, 55:852-863. 10.1046/j.1523-1755.1999.055003852.x, 10027922.
41. Mayet W, Schwarting A, Barreiros AP, Schlaak J, Neurath M. Anti-PR-3 antibodies induce endothelial IL-8 release. Eur J Clin Invest 1999, 29:973-979. 10.1046/j.1365-2362.1999.00555.x, 10583443.
42. Strieter RM, Kunkel SL, Showell HJ, Remick DG, Phan SH, Ward PA, Marks RM. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science 1989, 243:1467-1469. 10.1126/science.2648570, 2648570.
43. Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG. Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. Arthritis Rheum 2008, 58:2196-2205. 10.1002/art.23557, 18576340.
44. Khandaker MH, Mitchell G, Xu L, Andrews JD, Singh R, Leung H, Madrenas J, Ferguson SS, Feldman RD, Kelvin DJ. Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression. Blood 1999, 93:2173-2185.
45. Chan AT, Flossmann O, Mukhtyar C, Jayne DR, Luqmani RA. The role of biologic therapies in the management of systemic vasculitis. Autoimmun Rev 2006, 5:273-278. 10.1016/j.autrev.2006.01.003, 16697969.
46. Huugen D, Xiao H, van Esch A, Falk RJ, Peutz-Kootstra CJ, Buurman WA, Tervaert JW, Jennette JC, Heeringa P. Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha. Am J Pathol 2005, 167:47-58. 10.1016/S0002-9440(10)62952-5, 1603449, 15972951.
47. Noronha IL, Kruger C, Andrassy K, Ritz E, Waldherr R. In situ production of TNF-alpha, IL-1 beta and IL-2R in ANCA-positive glomerulonephritis. Kidney Int 1993, 43:682-692. 10.1038/ki.1993.98, 8455368.