Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti-proteinase 3 antibodies

Journal of the American Society of Nephrology

Volumn 18, Issue 8, 2007, Pages 2330-2339

  Brachemi, Soumeya ^a   Mambole, Agnès ^a   Fakhouri, Fadi ^b   Mouthon, Luc ^c   Guillevin, Loïc ^c   Lesavre, Philippe ^a,b   Halbwachs Mecarelli, Lise ^a,b  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Institut Cochin   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; ENZYME ANTIBODY; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HLA ANTIBODY; HLA ANTIGEN; INTERLEUKIN 8; MONOCLONAL ANTIBODY; MYELOBLASTIN; MYELOBLASTIN ANTIBODY; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEGRANULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY VESICLE; VASCULITIS;

EID: 34547619575     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006121309     Document Type: Article

References (50)

1. Jayne DR, Gaskin G, Pusey CD, Lockwood CM: ANCA and predicting relapse in systemic vasculitis. QJM 88: 127-133, 1995
2. Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, Meijer S, van der Giessen M, van der Hem GK, The TH, et al.: Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Intern Med 149: 2461-2465, 1989
3. Reumaux D, Duthilleul P, Roos D: Pathogenesis of diseases associated with antineutrophil cytoplasm autoantibodies. Hum Immunol 65: 1-12, 2004
4. Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L: Neutrophils: Molecules, functions and pathophysiological aspects. Lab Invest 80: 617-653, 2000
5. Halbwachs-Mecarelli L, Bessou G, Lesavre P, Lopez S, Witko-Sarsat V: Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool. FEBS Lett 374: 29-33, 1995
6. Witko-Sarsat V, Lesavre P, Lopez S, Bessou G, Hieblot C, Prum B, Noel LH, Guillevin L, Ravaud P, Sermet-Gaudelus I, Timsit J, Grunfeld JP, Halbwachs-Mecarelli L: A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J Am Soc Nephrol 10: 1224-1233, 1999
7. Rarok AA, Stegeman CA, Limburg PC, Kallenberg CG: Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. J Am Soc Nephrol 13: 2232-2238, 2002
8. Schreiber A, Luft FC, Kettritz R: Membrane proteinase 3 expression and ANCA-induced neutrophil activation. Kidney Int 65: 2172-2183, 2004
9. Charles LA, Caldas ML, Falk RJ, Terrell RS, Jennette JC: Antibodies against granule proteins activate neutrophils in vitro. J Leukoc Biol 50: 539-546, 1991
10. Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 87: 4115-4119, 1990
11. Keogan MT, Esnault VL, Green AJ, Lockwood CM, Brown DL: Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies. Clin Exp Immunol 90: 228-234, 1992
12. Lu X, Garfield A, Rainger GE, Savage CO, Nash GB: Mediation of endothelial cell damage by serine proteases, but not superoxide, released from antineutrophil cytoplasmic antibody-stimulated neutrophils. Arthritis Rheum 54: 1619-1628, 2006
13. Savage CO, Pottinger BE, Gaskin G, Pusey CD, Pearson JD: Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 141: 335-342, 1992
14. Mayet WJ, Meyer zum Buschenfelde KH: Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells. Clin Exp Immunol 94: 440-446, 1993
15. Radford DJ, Luu NT, Hewins P, Nash GB, Savage CO: Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis Rheum 44: 2851-2861, 2001
16. Buttrum SM, Drost EM, MacNee W, Goffin E, Lockwood CM, Hatton R, Nash GB: Rheological response of neutrophils to different types of stimulation. J Appl Physiol 77: 1801-1810, 1994
17. Tse WY, Nash GB, Hewins P, Savage CO, Adu D: ANCA-induced neutrophil F-actin polymerization: implications for microvascular inflammation. Kidney Int 67: 130-139, 2005
18. Abdel-Salam B, Iking-Konert C, Schneider M, Andrassy K, Hansch GM: Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood. Kidney Int 66: 1009-1017, 2004
19. Ambrose LR, Little MA, Nourshargh S, Pusey CD: Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy. Kidney Int 68: 2912-2913, 2005
20. Van Rossum AP, van der Geld YM, Limburg PC, Kallenberg CG: Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils. Kidney Int 68: 537-541, 2005
21. Rooney CP, Taggart C, Coakley R, McElvaney NG, O'Neill SJ: Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin. Am J Respir Cell Mol Biol 24: 747-754, 2001
22. Esnault VL, Testa A, Audrain M, Roge C, Hamidou M, Barrier JH, Sesboue R, Martin JP, Lesavre P: Alpha 1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis. Kidney Int 43: 1329-1332, 1993
23. Campbell EJ, Campbell MA: Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: Effects of substrate opsonization. J Cell Biol 106: 667-676, 1988
24. Vissers MC, George PM, Bathurst IC, Brennan SO, Winterbourn CC: Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils. J Clin Invest 82: 706-711, 1988
25. Nie J, Pei D: Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. Exp Cell Res 296: 145-150, 2004
26. Bouaouina M, Blouin E, Halbwachs-Mecarelli L, Lesavre P, Rieu P: TNF-induced beta2 integrin activation involves Src kinases and a redox-regulated activation of p38 MAPK. J Immunol 173: 1313-1320, 2004
27. Kettritz R, Jennette JC, Falk RJ: Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils. J Am Soc Nephrol 8: 386-394, 1997
28. Andrew D, Shock A, Ball E, Ortlepp S, Bell J, Robinson M: KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion. Eur J Immunol 23: 2217-2222, 1993
29. Chakrabarti S, Zee JM, Patel KD: Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release. J Leukoc Biol 79: 214-222, 2006
30. Bauer S, Abdgawad M, Gunnarsson L, Segelmark M, Tapper H, Hellmark T: Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol 81: 458-464, 2007
31. von Vietinghoff S, Tunnemann G, Eulenberg C, Wellner M, Cardoso MC, Luft FC, Kettritz R: NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. Blood 109: 4487-4493, 2007
32. Falk RJ, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 318: 1651-1657, 1988
33. Campbell EJ, Campbell MA, Owen CA: Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition. J Immunol 165: 3366-3374, 2000
34. Porges AJ, Redecha PB, Kimberly WT, Csernok E, Gross WL, Kimberly RP: Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa. J Immunol 153: 1271-1280, 1994
35. Mulder AH, Heeringa P, Brouwer E, Limburg PC, Kallenberg CG: Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): A Fc gamma RII-dependent process. Clin Exp Immunol 98: 270-278, 1994
36. Reumaux D, Vossebeld PJ, Roos D, Verhoeven AJ: Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: Relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood 86: 3189-3195, 1995
37. Hewins P, Williams JM, Wakelam MJ, Savage CO: Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fc-gamma receptors and CD18. J Am Soc Nephrol 15: 796-808, 2004
38. Yang JJ, Preston GA, Alcorta DA, Waga I, Munger WE, Hogan SL, Sekura SB, Phillips BD, Thomas RP, Jennette JC, Falk RJ: Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA). Kidney Int 62: 1638-1649, 2002
39. Williams JM, Ben-Smith A, Hewins P, Dove SK, Hughes P, McEwan R, Wakelam MJ, Savage CO: Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab′)2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. J Am Soc Nephrol 14: 661-669, 2003
40. David A, Fridlich R, Aviram I: The presence of membrane proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558. Exp Cell Res 308: 156-165, 2005
41. Fridlich R, David A, Aviram I: Membrane proteinase 3 and its interactions within microdomains of neutrophil membranes. J Cell Biochem 99: 117-125, 2006
42. Witko-Sarsat V, Cramer EM, Hieblot C, Guichard J, Nusbaum P, Lopez S, Lesavre P, Halbwachs-Mecarelli L: Presence of proteinase 3 in secretory vesicles: Evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. Blood 94: 2487-2496, 1999
43. Tosi MF, Zakem H, Berger M: Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 86: 300-308, 1990
44. Durant S, Pederzoli M, Lepelletier Y, Canteloup S, Nusbaum P, Lesavre P, Witko-Sarsat V: Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. J Leukoc Biol 75: 87-98, 2004
45. Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL: Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J Biol Chem 279: 17625-17633, 2004
46. Reumaux D, Hordijk PL, Duthilleul P Roos D: Priming by tumor necrosis factor-alpha of human neutrophil NADPH-oxidase activity induced by antiproteinase-3 or antimyeloperoxidase antibodies. J Leukoc Biol 80: 1424-1433, 2006
47. Seveau S, Lopez S, Lesavre P, Guichard J, Cramer EM, Halbwachs-Mecarelli L: Leukosialin (CD43, sialophorin) redistribution in uropods of polarized neutrophils is induced by CD43 cross-linking by antibodies, by colchicine or by chemotactic peptides. J Cell Sci 110: 1465-1475, 1997
48. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756, 1973
49. Capeillere-Blandin C, Gausson V, Nguyen AT, Descamps-Latscha B, Drueke T, Witko-Sarsat V: Respective role of uraemic toxins and myeloperoxidase in the uraemic state. Nephrol Dial Transplant 21: 1555-1563, 2006
50. Nusbaum P, Laine C, Bouaouina M, Seveau S, Cramer EM, Masse JM, Lesavre P, Halbwachs-Mecarelli L: Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scrambling during neutrophil apoptosis. J Biol Chem 280: 5843-5853, 2005