Novel cycloundecapeptides related to gramicidin S with both high antibiotic activity and low hemolytic activity

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 12, 2011, Pages 1481-1484

  Tamaki, Makoto ^a   Takanashi, Kazumasa ^a   Harada, Takuji ^a   Fujinuma, Kenta ^a   Shindo, Mitsuno ^b   Kimura, Masahiro ^b   Uchida, Yoshiki ^b  

^a TOHO UNIVERSITY   (Japan)

^b OSAKA SHOIN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Cycloundecapeptide; Gramicidin S analogue; High antibiotic activity; Low hemolytic activity; Structure activity relationship

Indexed keywords

ANTIBIOTIC AGENT; CYCLOUNDECAPEPTIDE DERIVATIVE; GRAMICIDIN S; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BETA SHEET; BLOOD CELL; CIRCULAR DICHROISM; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SHEEP; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CIRCULAR DICHROISM; GRAMICIDIN; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; SHEEP;

EID: 82955246146     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1481     Document Type: Article

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