Occupancy of dopamine D 2 and D 3 and serotonin 5-HT 1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography

Psychopharmacology

Volumn 218, Issue 3, 2011, Pages 579-587

  Seneca, Nicholas ^a,b   Finnema, Sjoerd J ^a   Laszlovszky, István ^c   Kiss, Béla ^c   Horváth, Attila ^c   Pásztor, Gabriella ^c   Kapás, Margó ^c   Gyertyán, István ^c   Farkas, Sándor ^c   Innis, Robert B ^b   Halldin, Christer ^a   Gulyás, Balázs ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c GEDEON RICHTER LTD   (Hungary)

Author keywords

Cariprazine; Dopamine D 2; Dopamine D 3; Nonhuman primate brain; Positron emission tomography (PET); Receptor occupancy; Serotonin 5 HT 1A

Indexed keywords

CARIPRAZINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RACLOPRIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RECEPTOR BINDING; LOW DRUG DOSE; MACACA FASCICULARIS; MESENCEPHALON; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAPHE NUCLEUS; RECEPTOR OCCUPANCY;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MACACA FASCICULARIS; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3;

EID: 82955233447     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2343-z     Document Type: Article

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