Cardioprotective effects of Lagenaria siceraria fruit juice on isoproterenol-induced myocardial infarction in wistar rats: A biochemical and histoarchitecture study

Journal of Young Pharmacists

Volumn 3, Issue 4, 2011, Pages 297-303

  Upaganlawar, A ^a   Balaraman, R ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Antioxidant activity; isoproterenol; Lagenaria siceraria; myocardial infarction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA TOCOPHEROL; CALCIUM ION; LACTATE DEHYDROGENASE; LAGENARIA SICERARIA EXTRACT; PLANT EXTRACT; POLYPHENOL; POTASSIUM ION; PROTECTIVE AGENT; SODIUM ION; UNCLASSIFIED DRUG; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FRUIT JUICE; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; HISTOPATHOLOGY; MALE; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TISSUE LEVEL; TREATMENT DURATION; URIC ACID BLOOD LEVEL; VITAMIN BLOOD LEVEL;

EID: 82955228945     PISSN: 09751483     EISSN: 09751505     Source Type: Journal    
DOI: 10.4103/0975-1483.90241     Document Type: Article

References (30)

1. Nadkarni KM. Indian Materica Medica, Vol. 1, A.K. Nadkarni, Popular Prakashan; 1992. p. 722-3.
2. Duke JA. Medicinal plants. Science 1985;229:1036-8.
3. Ghule BV, Ghanta MH, Upaganlawar AB, Yeole PG. Analgesic and anti-inflammatory activities of Lagenaria siceraria Stand. fruit juice extract in rats and mice. Pharmacog Mag 2006a;2:232-8.
4. Ghule BV, Ghante MH, Saoji AN, Yeole PG. Diuretic activity of Lagenaria siceraria fruit extract in rats. Indian J Pharm Sci 2006b;69:817-9.
5. Ghule BV, Ghante MH, Saoji AN, Yeole PG. Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (mol.) fruit extracts. Indian J Exp Biol 2006c;44:905-9. (Pubitemid 44736231)
6. Deshpande JR, Mishra MR, Meghre VS, Wadodkar SG, Dorle AK. Beneficial effects of Lagenaria siceraria (Mol.) Stand. fruit epicarp in animal models. Indian J Exp Biol 2008;40:234-42.
7. Fard MH, Bodhankar SL, Madhumira D. Cardioprotective activity of fruit of Lagenaria siceraria (Molina) Stanley on Doxorubicin induced cardiotoxicity in rats. Int J Pharmacol 2008;4:466-71.
8. Rona G, Chappel CI, Balazs T, Gaudry R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 1959;76:443-5.
9. Adameova A, Abdellatif Y, Dhalla NS. Role of excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease. Can J Physiol Pharmacol 2009;87:493-514.
10. Upaganlawar A, Balaraman R. Protective effects of Lagenaria siceraria (Molina) fruit juice in isoproterenol induced myocardial infarction. Int J Pharmacol 2010;6:645-51.
11. Desai ID. Vitamin E analysis methods for animal tissues. Met Enzymol 1984;66:138-47. (Pubitemid 14165381)
12. Bonting SL. Membrane ion transport. In: Pembroski TM, Schmidt TH, Blumchen G, editors. Bio-Behavioral Base of Coronary Heart Disease, Vol 1. London: Wiley Inter Science; 1970. p. 254-363.
13. Hjerken S, Pan H. Purification and characterization of two form of low affinity calcium ion ATPase from erythrocyte membrane. Biochim Biophys Acta 1983;728:281-8.
14. Ohinishi T, Suzuki T, Suzuki Y, Ozawa K. A Comparative study of plasma membrane Mg 2+ ATPase activities in normal, regenerating and malignant cells. Biochim Biophys Acta 1982;684:67-4. (Pubitemid 12186244)
15. Lowery OH, Rosenbrough NJ, Farr AI, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
16. Devika PT, Prince PSM. (-) Epigallocatechingallate (EGCG) prevents isoproterenol induced cardiac toxicity by stabilizing cardiac marker enzymes and membrane bound ATPases. J Pharm Pharmac 2008a;60:125-33.
17. McKenzie D, Henderson AR. Electrophoresis of lactate dehydrogenase isoenzymes. Clin Chem 1983;29:189-95. (Pubitemid 13167653)
18. Ying W. Deleterious network hypothesis of aging. Med Hypothesis 1997;48:143-8. (Pubitemid 27091229)
19. Wexler BC, Kittinger GN. Myocardial necrosis in rats: Serum enzymes, adrenal steroids and histopathological alterations. Circ Res 1963;13:159-71.
20. Rajadurai M, Prince PSM. Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Toxicology 2007; 230:178-88. (Pubitemid 46109139)
21. Niskanen LK, Laaksonen DE, Nyyssonen K, Alfthan G, Lakka HM, Lakka TA, et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: A prospective cohort study. Arch Intern Med 2004;164:1546-51. (Pubitemid 38970476)
22. McCord JM. Free radicals and myocardial ischemia. Free Radic Biol Med 1988;4:9-14.
23. Prabhu S, Jainu M, Sabiths KE, Devi CS. Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats. J Ethnopharmacol 2006;107:126-33. (Pubitemid 44038820)
24. Upaganlawar A, Gandhi H, Balaraman R. Effect of Vitamin E alone and in combination with lycopene on biochemical and histopathological alterations in isoproterenol induced myocardial infarction in rats. J Pharmacol Pharmacother 2010;1:24-31.
25. Upaganlawar A, Balaraman R. Combined effect of vitamin E and green tea on serum and heart lipids, lipid metabolizing enzymes and histopathological changes in isoproterenol induced myocardial infarction. Scienta Pharmaceutica 2009;77:791-803.
26. Upaganlawar A, Gandhi C, Balaraman R. Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats. Plant Foods Hum Nutr 2009;64:75-80.
27. Subash D, Narinder KK, Nityanand S. Effect of isoprenalin on lipid profile and cardiac enzymes in rats. Indian J Exp Biol 1978;16:376-8. (Pubitemid 8401139)
28. Mourelle M, Franco MT. Erythrocytes defects precede the onset of CCl4 induced liver cirrohsis: Protection of silymarin. Life Sci 1991;48:1083-90.
29. Trofimov GA, Alu B, Polozhentesv SD. Importance of determination of the content of lactate dehydrogenase and its isoenzymes in patients with myocardial infarction complicated by rupture of the heart. Kardiologiia 1975;15:82-4.
30. Priscilla DH, Prince PSM. Cardioprotective effect of gallic acid on cardiac troponon-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. Chem Biol Interact 2009;179:118-24.