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Volumn 24, Issue 1, 2012, Pages 97-102

Myelodysplasia and autoimmunity

Author keywords

Apoptosis; Autoimmunity; Cytokines; Interferon regulatory factor 1; Myelodysplasia

Indexed keywords

APOPTOSIS; AUTOIMMUNITY; BONE MARROW SUPPRESSION; CLINICAL FEATURE; CYTOKINE PRODUCTION; CYTOPENIA; DISEASE COURSE; EFFECTOR CELL; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA; MACROPHAGE; MYELODYSPLASTIC SYNDROME; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PRELEUKEMIA; PRIORITY JOURNAL; PROGNOSIS; REVIEW; T LYMPHOCYTE;

EID: 82955203695     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32834db4ee     Document Type: Review
Times cited : (28)

References (58)
  • 2
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood 2009; 114:937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 5
    • 0028886756 scopus 로고
    • Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: Response to immunosuppressive therapy
    • Enright H, Jacob HS, Vercellotti G, et al. Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: Response to immunosuppressive therapy. Br J Haematol 1995; 91:403-408.
    • (1995) Br J Haematol , vol.91 , pp. 403-408
    • Enright, H.1    Jacob, H.S.2    Vercellotti, G.3
  • 6
    • 0029932589 scopus 로고    scopus 로고
    • Immunological abnormalities in myelodysplastic syndromes
    • Hamblin TJ. Immunological abnormalities in myelodysplastic syndromes. Semin Hematol 1996; 33:150-162. (Pubitemid 26128722)
    • (1996) Seminars in Hematology , vol.33 , Issue.2 , pp. 150-162
    • Hamblin, T.J.1
  • 8
    • 2442534869 scopus 로고    scopus 로고
    • Autoimmune phenomena in myelodysplastic syndromes: A 4-yr prospective study
    • DOI 10.1093/rheumatology/keh136
    • Giannouli S, Voulgarelis M, Zintzaras E, et al. Autoimmune phenomena in myelodysplastic syndromes: A 4-yr prospective study. Rheumatology (Oxford) 2004; 43:626-632. (Pubitemid 38628195)
    • (2004) Rheumatology , vol.43 , Issue.5 , pp. 626-632
    • Giannouli, S.1    Voulgarelis, M.2    Zintzaras, E.3    Tzioufas, A.G.4    Moutsopoulos, H.M.5
  • 10
    • 0141923848 scopus 로고    scopus 로고
    • A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome
    • DOI 10.1182/blood-2002-11-3325
    • Saunthararajah Y, Nakamura R, Wesley R, et al. A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome. Blood 2003; 102:3025-3027. (Pubitemid 37248879)
    • (2003) Blood , vol.102 , Issue.8 , pp. 3025-3027
    • Saunthararajah, Y.1    Nakamura, R.2    Wesley, R.3    Wang, Q.J.4    Barrett, A.J.5
  • 11
    • 0027409958 scopus 로고
    • Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome
    • Yoshida Y. Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome. Leukemia 1993; 7:144-146. (Pubitemid 23048933)
    • (1993) Leukemia , vol.7 , Issue.1 , pp. 144-146
    • Yoshida, Y.1
  • 12
    • 0029020851 scopus 로고
    • Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
    • Raza A, Gezer S, Mundle S, et al. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood 1995; 86:268-276.
    • (1995) Blood , vol.86 , pp. 268-276
    • Raza, A.1    Gezer, S.2    Mundle, S.3
  • 13
    • 18344401654 scopus 로고    scopus 로고
    • Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin
    • DOI 10.1016/S0145-2126(96)00110-5, PII S0145212696001105
    • Hellström-Lindberg E, Kanter-Lewensohn L, Ost A. Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin. Leuk Res 1997; 21:415-425. (Pubitemid 27308236)
    • (1997) Leukemia Research , vol.21 , Issue.5 , pp. 415-425
    • Hellstrom-Lindberg, E.1    Kanter-Lewensohn, L.2    Ost, A.3
  • 14
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa R, Ginzton N, Rott LS, Greenberg PL. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood 1996; 88:4275-4287. (Pubitemid 26399175)
    • (1996) Blood , vol.88 , Issue.11 , pp. 4275-4287
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.S.3    Greenberg, P.L.4
  • 15
    • 0031863816 scopus 로고    scopus 로고
    • Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes
    • DOI 10.1046/j.1365-2141.1998.00708.x
    • Parker JE, Mufti GJ. Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes. Br J Haematol 1998; 101:220-230. (Pubitemid 28261106)
    • (1998) British Journal of Haematology , vol.101 , Issue.2 , pp. 220-230
    • Parker, J.E.1    Mufti, G.J.2
  • 16
    • 0030293115 scopus 로고    scopus 로고
    • The myelodysplastic syndromes in 1996: Complex stem cell disorders confounded by dual actions of cytokines
    • DOI 10.1016/S0145-2126(96)00027-6, PII S0145212696000276
    • Raza A, Gregory SA, Preisler HD. The myelodysplastic syndromes in 1996: Complex stem cell disorders confounded by dual actions of cytokines. Leuk Res 1996; 20:881-890. (Pubitemid 27042321)
    • (1996) Leukemia Research , vol.20 , Issue.11-12 , pp. 881-890
    • Raza, A.1    Gregory, S.A.2    Preisler, H.D.3
  • 17
    • 0032840760 scopus 로고    scopus 로고
    • - hematopoietic progenitor cells by suppressing apoptosis
    • DOI 10.1016/S0301-472X(99)00073-9, PII S0301472X99000739
    • Josefsen D, Myklebust JH, Lynch DH, et al. Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis. Exp Hematol 1999; 27:1451-1459. (Pubitemid 29409464)
    • (1999) Experimental Hematology , vol.27 , Issue.9 , pp. 1451-1459
    • Josefsen, D.1    Myklebust, J.H.2    Lynch, D.H.3    Stokke, T.4    Blomhoff, H.K.5    Smeland, E.B.6
  • 18
    • 0033176431 scopus 로고    scopus 로고
    • Spontaneous down-regulation of Fas-associated phosphatase-1 may contribute to excessive apoptosis in myelodysplastic marrows
    • Mundle SD, Mativi BY, Bagai K, et al. Spontaneous down-regulation of Fas-associated phosphatase-1 may contribute to excessive apoptosis in myelodysplastic marrows. Int J Hematol 1999; 70:83-90.
    • (1999) Int J Hematol , vol.70 , pp. 83-90
    • Mundle, S.D.1    Mativi, B.Y.2    Bagai, K.3
  • 19
    • 73849128091 scopus 로고    scopus 로고
    • A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome
    • Barlow JL, Drynan LF, Hewett DR, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med 2010; 16:59-66.
    • (2010) Nat Med , vol.16 , pp. 59-66
    • Barlow, J.L.1    Drynan, L.F.2    Hewett, D.R.3
  • 20
    • 33947224233 scopus 로고    scopus 로고
    • CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
    • DOI 10.1182/blood-2006-01-030643
    • Sloand EM, Pfannes L, Chen G, et al. CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins. Blood 2007; 109:2399-2405. (Pubitemid 46425880)
    • (2007) Blood , vol.109 , Issue.6 , pp. 2399-2405
    • Sloand, E.M.1    Pfannes, L.2    Chen, G.3    Shah, S.4    Solomou, E.E.5    Barrett, J.6    Young, N.S.7
  • 21
    • 0027525323 scopus 로고
    • Restoration of impaired cytokine secretion from monocytes of patients with myelodysplastic syndromes after in vivo treatment with GM-CSF or IL-3
    • Maurer AB, Ganser A, Buhl R, et al. Restoration of impaired cytokine secretion from monocytes of patients with myelodysplastic syndromes after in vivo treatment with GM-CSF or IL-3. Leukemia 1993; 7:1728-1733. (Pubitemid 23347288)
    • (1993) Leukemia , vol.7 , Issue.11 , pp. 1728-1733
    • Maurer, A.B.1    Ganser, A.2    Buhl, R.3    Seipelt, G.4    Ottmann, O.G.5    Mentzel, U.6    Geissler, R.G.7    Hoelzer, D.8
  • 23
    • 0032972264 scopus 로고    scopus 로고
    • Correlation of tumor necrosis factor α (TNFα) with high Caspase 3-like activity in myelodysplastic syndromes
    • DOI 10.1016/S0304-3835(99)00072-5, PII S0304383599000725
    • Mundle SD, Reza S, Ali A, et al. Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes. Cancer Lett 1999; 140:201-207. (Pubitemid 29251332)
    • (1999) Cancer Letters , vol.140 , Issue.1-2 , pp. 201-207
    • Mundle, S.D.1    Reza, S.2    Ali, A.3    Mativi, B.Y.4    Shetty, V.5    Venugopal, P.6    Gregory, S.A.7    Raza, A.8
  • 24
    • 0037411227 scopus 로고    scopus 로고
    • Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes
    • DOI 10.1016/S0145-2126(02)00095-4, PII S0145212602000954
    • Sawanobori M, Yamaguchi S, Hasegawa M, et al. Expression of TNF receptors and related signalling molecules in the bone marrow from patients with myelodysplastic syndromes. Leuk Res 2003; 27:583-591. (Pubitemid 36398093)
    • (2003) Leukemia Research , vol.27 , Issue.7 , pp. 583-591
    • Sawanobori, M.1    Yamaguchi, S.2    Hasegawa, M.3    Inoue, M.4    Suzuki, K.5    Kamiyama, R.6    Hirokawa, K.7    Kitagawa, M.8
  • 25
    • 38349113450 scopus 로고    scopus 로고
    • Tumour necrosis factor-induced gene expression in human marrow stroma: Clues to the pathophysiology of MDS?
    • Stirewalt DL, Mhyre AJ, Marcondes M, et al. Tumour necrosis factor-induced gene expression in human marrow stroma: Clues to the pathophysiology of MDS? Br J Haematol 2000; 140:444-453.
    • (2000) Br J Haematol , vol.140 , pp. 444-453
    • Stirewalt, D.L.1    Mhyre, A.J.2    Marcondes, M.3
  • 26
    • 0029016931 scopus 로고
    • Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro
    • Maciejewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995; 85:3183-3190.
    • (1995) Blood , vol.85 , pp. 3183-3190
    • Maciejewski, J.1    Selleri, C.2    Anderson, S.3    Young, N.S.4
  • 27
    • 0032519537 scopus 로고    scopus 로고
    • Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon γ to produce erythroid cell apoptosis
    • Dai CH, Price JO, Brunner T, Krantz SB. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood 1998; 91:1235-1242. (Pubitemid 28086876)
    • (1998) Blood , vol.91 , Issue.4 , pp. 1235-1242
    • Dai, C.-H.1    Price, J.O.2    Brunner, T.3    Krantz, S.B.4
  • 28
    • 79960280273 scopus 로고    scopus 로고
    • Effects of thalidomide on longterm bone marrow cultures from patients with myelodysplastic syndromes: Induction of IL-10 expression in the stromal layers
    • Lazarini M, Traina F, Winnischofer SM, et al. Effects of thalidomide on longterm bone marrow cultures from patients with myelodysplastic syndromes: Induction of IL-10 expression in the stromal layers. Leuk Res 2011; 35:1102-1107.
    • (2011) Leuk Res , vol.35 , pp. 1102-1107
    • Lazarini, M.1    Traina, F.2    Winnischofer, S.M.3
  • 30
    • 0035892123 scopus 로고    scopus 로고
    • Expression of tumor necrosis factorrelated apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis
    • Zang DY, Goodwin RG, Loken MR, et al. Expression of tumor necrosis factorrelated apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis. Blood 2001; 98:3058-3065.
    • (2001) Blood , vol.98 , pp. 3058-3065
    • Zang, D.Y.1    Goodwin, R.G.2    Loken, M.R.3
  • 31
    • 54049149411 scopus 로고    scopus 로고
    • Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS
    • Zhou L, Nguyen AN, Sohal D, et al. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood 2008; 112:3434-3443.
    • (2008) Blood , vol.112 , pp. 3434-3443
    • Zhou, L.1    Nguyen, A.N.2    Sohal, D.3
  • 32
    • 66349089112 scopus 로고    scopus 로고
    • Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance
    • Barrett AJ, Sloand E. Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance. Haematologica 2009; 94:449-451.
    • (2009) Haematologica , vol.94 , pp. 449-451
    • Barrett, A.J.1    Sloand, E.2
  • 33
    • 0033973769 scopus 로고    scopus 로고
    • Myelodysplastic syndrome and aplastic anemia: Distinct entities or diseases linked by a common pathophysiology?
    • Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anemia: Distinct entities or diseases linked by a common pathophysiology? Semin Hematol 2000; 37:15-29. (Pubitemid 30080244)
    • (2000) Seminars in Hematology , vol.37 , Issue.1 , pp. 15-29
    • Barrett, J.1    Saunthararajah, Y.2    Molldrem, J.3
  • 34
    • 0036400123 scopus 로고    scopus 로고
    • Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome
    • DOI 10.1046/j.1365-2141.2002.03802.x
    • Melenhorst JJ, Eniafe R, Follmann D, et al. Molecular and flow cytometric characterization of the CD4 and CD8 T cell repertoire in patients with myelodysplastic syndrome. Br J Haematol 2002; 119:97-105. (Pubitemid 35176503)
    • (2002) British Journal of Haematology , vol.119 , Issue.1 , pp. 97-105
    • Melenhorst, J.J.1    Eniafe, R.2    Follmann, D.3    Nakamura, R.4    Kirby, M.5    Barrett, A.J.6
  • 35
    • 0034782479 scopus 로고    scopus 로고
    • Oligoclonal T cell expansion in myelodysplastic syndrome: Evidence for an autoimmune process
    • DOI 10.1016/S0145-2126(01)00083-2, PII S0145212601000832
    • Epperson DE, Nakamura R, Saunthararajah Y, et al. Oligoclonal T cell expansion in myelodysplastic syndrome: Evidence for an autoimmune process. Leuk Res 2001; 25:1075-1083. (Pubitemid 33000488)
    • (2001) Leukemia Research , vol.25 , Issue.12 , pp. 1075-1083
    • Epperson, D.E.1    Nakamura, R.2    Saunthararajah, Y.3    Melenhorst, J.4    Barrett, A.J.5
  • 36
    • 0037376257 scopus 로고    scopus 로고
    • Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia
    • DOI 10.1016/S0145-2126(02)00173-X, PII S014521260200173X
    • Matsutani T, Yoshioka T, Tsuruta Y, et al. Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia. Leuk Res 2003; 27:305-312. (Pubitemid 36071387)
    • (2003) Leukemia Research , vol.27 , Issue.4 , pp. 305-312
    • Matsutani, T.1    Yoshioka, T.2    Tsuruta, Y.3    Shimamoto, T.4    Ohyashiki, J.H.5    Suzuki, R.6    Ohyashiki, K.7
  • 37
    • 0034765667 scopus 로고    scopus 로고
    • Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia
    • DOI 10.1016/S0301-472X(01)00736-6, PII S0301472X01007366
    • Kook H, Zeng W, Guibin C, et al. Increased cytotoxic T cells with effector phenotype in aplastic anemia an myelodysplasia. Exp Hematol 2001; 29:1270-1277. (Pubitemid 33033303)
    • (2001) Experimental Hematology , vol.29 , Issue.11 , pp. 1270-1277
    • Kook, H.1    Zeng, W.2    Guibin, C.3    Kirby, M.4    Young, N.S.5    Maciejewski, J.P.6
  • 38
    • 0037111548 scopus 로고    scopus 로고
    • Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression
    • DOI 10.1182/blood-2002-01-0155
    • Kochenderfer JN, Kobayashi S, Wieder ED, et al. Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression. Blood 2002; 100:3639-3645. (Pubitemid 35303934)
    • (2002) Blood , vol.100 , Issue.10 , pp. 3639-3645
    • Kochenderfer, J.N.1    Kobayashi, S.2    Wieder, E.D.3    Su, C.4    Molldrem, J.J.5
  • 40
    • 69249220181 scopus 로고    scopus 로고
    • A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS
    • Keilholz U, Letsch A, Busse A, et al. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood 2009; 113:6541-6548.
    • (2009) Blood , vol.113 , pp. 6541-6548
    • Keilholz, U.1    Letsch, A.2    Busse, A.3
  • 41
    • 34248572345 scopus 로고    scopus 로고
    • H-17 cells in the circle of immunity and autoimmunity
    • DOI 10.1038/ni0407-345, PII NI0407-345
    • Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007; 8:345-350. (Pubitemid 46745409)
    • (2007) Nature Immunology , vol.8 , Issue.4 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 42
    • 35649018292 scopus 로고    scopus 로고
    • Interplay between pathogenic Th17 and regulatory T cells
    • DOI 10.1136/ard.2007.078527
    • Oukka M. Interplay between pathogenic Th17 and regulatory T cells. Ann Rheum Dis 2007; 66 (Suppl 3):iii87-iii90. (Pubitemid 350032642)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.SUPPL. 3
    • Oukka, M.1
  • 44
    • 61849168098 scopus 로고    scopus 로고
    • IL-17 producing CD4(+) T cells, proinflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome
    • Kordasti SY, Afzali B, Lim Z, et al. IL-17 producing CD4(+) T cells, proinflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome. Br J Haematol 2009; 145:64-72.
    • (2009) Br J Haematol , vol.145 , pp. 64-72
    • Kordasti, S.Y.1    Afzali, B.2    Lim, Z.3
  • 45
    • 0029071829 scopus 로고
    • Immune-mediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features
    • Billström R, Johansson H, Johansson B, Mitelman F. Immune-mediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features. Eur J Haematol 1995; 55:42-48.
    • (1995) Eur J Haematol , vol.55 , pp. 42-48
    • Billström, R.1    Johansson, H.2    Johansson, B.3    Mitelman, F.4
  • 46
    • 0024114474 scopus 로고
    • Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements
    • Fujita T, Sakakibara J, Sudo Y, et al. Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements. EMBO J 1988; 7:3397-3405.
    • (1988) EMBO J , vol.7 , pp. 3397-3405
    • Fujita, T.1    Sakakibara, J.2    Sudo, Y.3
  • 47
    • 0023788435 scopus 로고
    • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements
    • Miyamoto M, Fujita T, Kimura Y, et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 1988; 54:903-913.
    • (1988) Cell , vol.54 , pp. 903-913
    • Miyamoto, M.1    Fujita, T.2    Kimura, Y.3
  • 49
    • 0028007114 scopus 로고
    • Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation
    • Harada H, Kondo T, Ogawa S, et al. Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. Oncogene 1994; 9:3313-3320.
    • (1994) Oncogene , vol.9 , pp. 3313-3320
    • Harada, H.1    Kondo, T.2    Ogawa, S.3
  • 51
    • 77950542157 scopus 로고    scopus 로고
    • Innate immune signaling in the myelodysplastic syndromes
    • This article highlights the prominent role of the innate immune pathway in regulating hematopoiesis. Increased activation of the innate immune pathway may contribute to dysregulated hematopoiesis, dysplasia, and clonal expansion in myelodysplastic syndromes
    • Starczynowski DT, Karsan A. Innate immune signaling in the myelodysplastic syndromes. Hematol Oncol Clin North Am 2010; 24:343-359. This article highlights the prominent role of the innate immune pathway in regulating hematopoiesis. Increased activation of the innate immune pathway may contribute to dysregulated hematopoiesis, dysplasia, and clonal expansion in myelodysplastic syndromes.
    • (2010) Hematol Oncol Clin North Am , vol.24 , pp. 343-359
    • Starczynowski, D.T.1    Karsan, A.2
  • 52
    • 33947255107 scopus 로고    scopus 로고
    • Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes
    • DOI 10.1158/1078-0432.CCR-06-2108
    • Maratheftis CI, Andreakos E, Moutsopoulos HM, Voulgarelis M. Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes. Clin Cancer Res 2007; 13:1154-1160. (Pubitemid 46424055)
    • (2007) Clinical Cancer Research , vol.13 , Issue.4 , pp. 1154-1160
    • Maratheftis, C.I.1    Andreakos, E.2    Moutsopoulos, H.M.3    Voulgarelis, M.4
  • 53
    • 37149013022 scopus 로고    scopus 로고
    • RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II
    • DOI 10.1593/neo.07640
    • Maratheftis CI, Giannouli S, Spachidou MP, et al. RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II. Neoplasia 2007; 9:1012-1020. (Pubitemid 350255348)
    • (2007) Neoplasia , vol.9 , Issue.12 , pp. 1012-1020
    • Maratheftis, C.I.1    Giannouli, S.2    Spachidou, M.P.3    Panayotou, G.4    Voulgarelis, M.5
  • 54
    • 67349111091 scopus 로고    scopus 로고
    • Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)- alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist deficient mice
    • Jung YO, Cho ML, Lee SY, et al. Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)- alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist deficient mice. Immunol Lett 2009; 123:138-143.
    • (2009) Immunol Lett , vol.123 , pp. 138-143
    • Jung, Y.O.1    Cho, M.L.2    Lee, S.Y.3
  • 55
    • 79951996237 scopus 로고    scopus 로고
    • Immunosuppressive therapy for patients with myelodysplastic syndrome: A prospective randomized multicenter phase III trial comparing antithymocyte globulin plus cyclosporine with best supportive care-SAKK 33/99
    • Passweg JR, Giagounidis AA, Simcock M, et al. Immunosuppressive therapy for patients with myelodysplastic syndrome: A prospective randomized multicenter phase III trial comparing antithymocyte globulin plus cyclosporine with best supportive care-SAKK 33/99. J Clin Oncol 2011; 29:303-309.
    • (2011) J Clin Oncol , vol.29 , pp. 303-309
    • Passweg, J.R.1    Giagounidis, A.A.2    Simcock, M.3
  • 56
    • 79955739178 scopus 로고    scopus 로고
    • Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: Implications for immunotherapy
    • Aggarwal S, van de Loosdrecht AA, Alhan C, et al. Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: Implications for immunotherapy. Br J Haematol 2011; 153:568-581.
    • (2011) Br J Haematol , vol.153 , pp. 568-581
    • Aggarwal, S.1    Van De Loosdrecht, A.A.2    Alhan, C.3
  • 57
    • 5744243331 scopus 로고    scopus 로고
    • Immunobiologic therapies for Myelodysplastic syndrome
    • Appelbaum FR. Immunobiologic therapies for Myelodysplastic syndrome. Best Pract Res Clin Haematol 2004; 17:653-656.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 653-656
    • Appelbaum, F.R.1
  • 58
    • 38049188363 scopus 로고    scopus 로고
    • Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    • Rezvani K, Yong AS, Mielke S, et al. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 2008; 111:236-242.
    • (2008) Blood , vol.111 , pp. 236-242
    • Rezvani, K.1    Yong, A.S.2    Mielke, S.3


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