Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine

Biochemistry

Volumn 50, Issue 49, 2011, Pages 10573-10575

  Young, Anthony P ^a   Bandarian, Vahe ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEAL; CARBON ATOMS; IMIDAZOLINES; POTENTIAL SUBSTRATE; PYRUVATES;

BIOCHEMISTRY; RNA;

SUBSTRATES;

4 NORWYOSINE; CARBON; CARBON 13; GUANOSINE DERIVATIVE; IMIDAZOLINE; METHYL GROUP; N METHYLGUANOSINE; PYRUVIC ACID; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; ION PAIR CHROMATOGRAPHY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY ANALYSIS;

CARBON; GUANOSINE; IMIDAZOLINES; METHANOCOCCUS; NUCLEOSIDES; OXIDOREDUCTASES; PYRUVIC ACID; RECOMBINANT PROTEINS; RNA, TRANSFER, PHE; SUBSTRATE SPECIFICITY; TRNA METHYLTRANSFERASES;

EID: 82955169554     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2015053     Document Type: Article

References (14)

1. Rozenski, J., Crain, P. F., and McCloskey, J. A. (1999) The RNA Modification Database: 1999 update Nucleic Acids Res. 27, 196-197 (Pubitemid 29209437)
2. RajBhandary, U. L. and Chang, S. H. (1968) Studies on polynucleotides. LXXXII. Yeast phenylalanine transfer ribonucleic acid: Partial digestion with ribonuclease T-1 and derivation of the total primary structure J. Biol. Chem. 243, 598-608
3. Noma, A., Kirino, Y., Ikeuchi, Y., and Suzuki, T. (2006) Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA EMBO J. 25, 2142-2154
4. Sofia, H. J., Chen, G., Hetzler, B. G., Reyes-Spindola, J. F., and Miller, N. E. (2001) Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: Functional characterization using new analysis and information visualization methods Nucleic Acids Res. 29, 1097-1106 (Pubitemid 32186195)
5. Frey, P. A., Hegeman, A. D., and Ruzicka, F. J. (2008) The Radical SAM Superfamily Crit. Rev. Biochem. Mol. Biol. 43, 63-88 (Pubitemid 351315858)
6. Suzuki, Y., Noma, A., Suzuki, T., Senda, M., Senda, T., Ishitani, R., and Nureki, O. (2007) Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA J. Mol. Biol. 372, 1204-1214 (Pubitemid 47376935)
7. Goto-Ito, S., Ishii, R., Ito, T., Shibata, R., Fusatomi, E., Sekine, S. I., Bessho, Y., and Yokoyama, S. (2007) Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis Acta Crystallogr. D63, 1059-1068 (Pubitemid 47480518)
8. Christian, T. and Hou, Y. M. (2007) Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases J. Mol. Biol. 373, 623-632 (Pubitemid 47488397)
9. Miles, Z. D., McCarty, R. M., Molnar, G., and Bandarian, V. (2011) Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification Proc. Natl. Acad. Sci. U.S.A. 108, 7368-7372
10. Zhou, S., Sitaramaiah, D., Noon, K. R., Guymon, R., Hashizume, T., and McCloskey, J. A. (2004) Structures of two new "minimalist" modified nucleosides from archaeal tRNA Bioorg. Chem. 32, 82-91 (Pubitemid 38251638)
11. Vey, J. L. and Drennan, C. L. (2011) Structural insights into radical generation by the radical SAM superfamily Chem. Rev. 111, 2487-2506
12. Knappe, J., Neugebauer, F. A., Blaschkowski, H. P., and Ganzler, M. (1984) Post-translational activation introduces a free radical into pyruvate formate-lyase Proc. Natl. Acad. Sci. U.S.A. 81, 1332-1335 (Pubitemid 14173463)
13. Layer, G., Kervio, E., Morlock, G., Heinz, D. W., Jahn, D., Retey, J., and Schubert, W. D. (2005) Structural and functional comparison of HemN to other radical SAM enzymes Biol. Chem. 386, 971-980 (Pubitemid 41548729)
14. de Crecy-Lagard, V., Brochier-Armanet, C., Urbonavicius, J., Fernandez, B., Phillips, G., Lyons, B., Noma, A., Alvarez, S., Droogmans, L., Armengaud, J., and Grosjean, H. (2010) Biosynthesis of wyosine derivatives in tRNA: An ancient and highly diverse pathway in Archaea Mol. Biol. Evol. 27, 2062-2077