Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients

Journal of Cardiology

Volumn 58, Issue 3, 2011, Pages 216-225

  Jha, Hem Chandra ^a   Srivastava, Pragya ^a   Vardhan, Harsh ^a   Singh, Laishram Chandreshwor ^a   Bhengraj, Apurb Rashmi ^a   Prasad, Jagdish ^a   Mittal, Aruna ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

Caspase; Human atherosclerosis; Inflammatory cytokines; Lipid; Necrosis; Pre apoptotic

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CHEMOKINE; CYTOKINE RECEPTOR; FLICE INHIBITORY PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 60; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADULT; APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHLAMYDOPHILA PNEUMONIAE; CLINICAL ARTICLE; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DNA MICROARRAY; FEMALE; GENE EXPRESSION; HUMAN; MALE; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; APOPTOSIS; BACTERIAL PROTEINS; CASPASES; CHAPERONIN 60; CHLAMYDOPHILA PNEUMONIAE; CORONARY ARTERY DISEASE; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLAQUE, ATHEROSCLEROTIC; POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 82855175176     PISSN: 09145087     EISSN: 18764738     Source Type: Journal    
DOI: 10.1016/j.jjcc.2011.07.010     Document Type: Article

References (60)

1. Grayston J.T., Kuo C.C., Coulson A.S., Campbell L.A., Lawrence R.D., Lee M.J., Strandness E.D., Wang S. Chlamydia pneumoniae (TWAR) in atherosclerosis of the carotid artery. Circulation 1995, 92:3397-3400.
2. Jha H.C., Vardhan H., Gupta R., Varma R., Prasad J., Mittal A. Higher incidence of persistent chronic infection of Chlamydia pneumoniae among coronary artery disease patients in India is a cause of concern. BMC Infect Dis 2007, 7:48.
3. Maass M., Bartels C., Engel P.M., Mamat U., Sievers H.H. Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease. J Am Coll Cardiol 1998, 31:827-832.
4. Ong G., Thomas B.J., Mansfield A.O., Davidson B.R., Taylor-Robinson D. Detection and widespread distribution of Chlamydia pneumoniae in the vascular system and its possible implications. J Clin Pathol 1996, 49:102-106.
5. Paterson D.L., Hall J., Rasmussen S.J., Timms P. Failure to detect Chlamydia pneumoniae in atherosclerotic plaques of Australian patients. Pathology 1998, 30:169-172.
6. Taylor-Robinson D. Chlamydia pneumoniae in vascular tissue. Atherosclerosis 1998, 140:S21-S24.
7. Hong Y.J., Jeong M.H., Choi Y.H., Ma E.H., Ko J.S., Lee M.G., Park K.H., Kang J.C. Age-related differences in virtual histology-intravascular ultrasound findings in patients with coronary artery disease. J Cardiol 2010, 55:224-231.
8. Johnston S.C., Messina L.M., Browner W.S., Lawton M.T., Morris C., Dean D. C-reactive protein levels and viable Chlamydia pneumoniae in carotid artery atherosclerosis. Stroke 2001, 32:2748-2752.
9. Godzik K.L., O'Brien E.R., Wang S.K., Kuo C.C. In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae. J Clin Microbiol 1995, 33:2411-2414.
10. Kalayoglu M.V., Byrne G.I. A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide. Infect Immun 1998, 66:5067-5072.
11. Sasu S., LaVerda D., Qureshi N., Golenbock D.T., Beasley D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res 2001, 89:244-250.
12. Mandal K., Jahangiri M., Xu Q. Autoimmunity to heat shock proteins in atherosclerosis. Autoimmun Rev 2004, 3:31-37.
13. Streblow N., Orloff S.L., Nelson J.A. Do pathogens accelerate atherosclerosis?. J Nutr 2001, 131:2798S-2804S.
14. Lim S.Y., Bae E.H., Jeong M.H., Kim J.H., Hong Y.J., Sim D.S., Kim Y.S., Kang J.C. The effect of alpha lipoic acid in a porcine in-stent restenosis model. J Cardiol 2009, 54:375-385.
15. Molestina R.E., Miller R.D., Ramirez J.A., Summersgill J.T. Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes. Infect Immun 1999, 67:1323-1330.
16. Zakynthinos E., Pappa N. Inflammatory biomarkers in coronary artery disease. J Cardiol 2009, 53:317-333.
17. Kraaijeveld A.O., de Jager S.C., de Jager W.J., Prakken B.J., McColl S.R., Haspels I., Putter H., van Berkel T.J., Nagelkerken L., Jukema J.W., Biessen E.A. CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. Circulation 2007, 116:1931-1941.
18. KimYH, Choi S.Y., Suh J.H., Kim T.K., Seung K.B., Wang Y.P., Chang K. The effect of Chlamydia pneumoniae on the expression of peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells. Yonsei Med J 2008, 49:230-236.
19. Ricote M., Glass C.K. New roles for PPARs in cholesterol homeostasis. Trends Pharmacol Sci 2001, 22:441-443.
20. Fischer S.F., Schwarz C., Vier J., Hacker G. Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells. Infect Immun 2001, 69:7121-7129.
21. Stenner-Liewen F., Liewen H., Zapata J.M., Pawlowski K., Godzik A., Reed J.C. CADD, a Chlamydia protein that interacts with death receptors. J Biol Chem 2002, 277:9633-9636.
22. Saito Y., Kondo H., Hojo Y. Granzyme B as a novel factor involved in cardiovascular diseases. J Cardiol 2011, 57:141-147.
23. Fischer S.F., Vier J., Kirschnek S., Klos A., Hess S., Ying S., Häcker G. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med 2004, 200:905-916.
24. Yaraei K., Campbell L.A., Zhu X., Liles W.C., Kuo C.C., Rosenfeld M.E. Chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathway. Infect Immun 2005, 73:4315-4322.
25. Jha H.C., Srivastava P., Divya A., Prasad J., Mittal A. Prevalence of Chlamydophila pneumoniae is higher in aorta and coronary artery than in carotid artery of coronary artery disease patients. APMIS 2009, 117:905-911.
26. Hauer A.D., de Vos P., Peterse N., ten Cate H., van Berkel T.J., Stassen F.R., Kuiper J. Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr-/- mice. Cardiovasc Res 2006, 69:280-288.
27. Cho S.H., Jeong M.H., Park I.H., Choi J.S., Yoon H.J., Kim K.H., Hong Y.J., Kang J.C. Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina. J Cardiol 2009, 54:183-191.
28. Jha H.C., Prasad J., Mittal A. High immunoglobulin A seropositivity for combined Chlamydia pneumoniae, Helicobacter pylori infection, and high-sensitivity C-reactive protein in coronary artery disease patients in India can serve as atherosclerotic marker. Heart Vessels 2008, 23:390-396.
29. Kalayoglu M.V., Perkins B.N., Byrne G.I. Chlamydia pneumoniae-infected monocytes exhibit increased adherence to human aortic endothelial cells. Microbes Infect 2001, 3:963-969.
30. Dittrich R., Dragonas C., Mueller A., Maltaris T., Rupp J., Beckmann M.W., Maass M. Endothelial Chlamydia pneumoniae infection promotes oxidation of LDL. Biochem Biophys Res Commun 2004, 319:501-505.
31. Van Gils J.M., Zwaginga J.J., Hordijk P.L. Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 2009, 85:195-204.
32. Kanazawa H. VEGF, angiopoietin-1 and -2 in bronchial asthma: new molecular targets in airway angiogenesis and microvascular remodeling. Recent Pat Inflamm Allergy Drug Discov 2007, 1:1-8.
33. Fan T., Lu H., Hu H., Shi L., McClarty G.A., Nance D.M., Greenberg A.H., Zhong G. Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 1998, 187:487-496.
34. Mosorin M., Surcel H.M., Laurila A., Lehtinen M., Karttunen R., Juvonen J., Paavonen J., Morrison R.P., Saikku P., Juvonen T. Detection of Chlamydia pneumoniae-reactive T lymphocytes in human atherosclerotic plaques of carotid artery. Arterioscler Thromb Vasc Biol 2000, 20:1061-1067.
35. Wahl C., Oswald F., Simnacher U., Weiss S., Marre R., Essig A. Survival of Chlamydia pneumoniae-infected Mono Mac 6 cells is dependent on NF-kappa B binding activity. Infect Immun 2001, 69:7039-7045.
36. Miyairi I., Byrne G.I. Chlamydia and programmed cell death. Curr Opin Microbiol 2006, 9:102-108.
37. Dean D., Powers V.C. Persistent Chlamydia trachomatis infections resist apoptotic stimuli. Infect Immun 2001, 69:2442-2447.
38. Herold M.J., Kuss A.W., Kraus C., Berberich I. Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells. J Immunol 2002, 168:3902-3909.
39. Chandler J.M., Cohen G.M., MacFarlane M. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem 1998, 273:10815-10818.
40. Hippenstiel S., Schmeck B., N'Guessan P.D., Seybold J., Krull M., Preissner K., Eichel-Streiber C.V., Suttorp N. Rho protein inactivation induced apoptosis of cultured human endothelial cells. Am J Physiol Lung Cell Mol Physiol 2002, 283:L830-L838.
41. Bachmaier K., Neu N., delaMaza L.M., Pal S., Hessel A., Penninge J.M. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999, 283:1335-1339.
42. Hansson G.K., Robertson A.K., Soderberg-Naucler C. Inflammation and atherosclerosis. Annu Rev Pathol 2006, 1:297-329.
43. Rossmann A., Henderson B., Heidecker B., Seiler R., Fraedrich G., Singh M., Parson W., Keller M., Grubeck-Loebenstein B., Wick G. T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire. Exp Gerontol 2008, 43:229-237.
44. Halme S., Latvala J., Karttunen R., Palatsi I., Saikku P., Surcel H.M. Cell-mediated immune response during primary Chlamydia pneumoniae infection. Infect Immun 2000, 68:7156-7158.
45. Loomis W.P., Starnbach M.N. T cell responses to Chlamydia trachomatis. Curr Opin Microbiol 2002, 5:87-91.
46. Rengarajan J., Szabo S.J., Glimcher L.H. Transcriptional regulation of Th1/Th2 polarization. Immunol Today 2000, 21:479-483.
47. Gupta R., Vardhan H., Srivastava P., Salhan S., Mittal A. Modulation of cytokines and transcription factors (T-Bet and GATA3) in CD4 enriched cervical cells of Chlamydia trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and C. Reprod Biol Endocrinol 2009, 7:84.
48. Jha H.C., Srivastava P., Sarkar R., Prasad J., Mittal A.S. Association of plasma circulatory markers, Chlamydia pneumoniae, and high sensitive C-reactive protein in coronary artery disease patients of India. Mediators Inflamm 2009, 2009:561532.
49. Gori A.M., Cesari F., Marcucci R., Giusti B., Paniccia R., Antonucci E., Gensini G.F., Abbate R. The balance between pro- and anti-inflammatory cytokines is associated with platelet aggregability in acute coronary syndrome patients. Atherosclerosis 2009, 202:255-262.
50. Haranaga S., Yamaguchi H., Friedman H., Izumi S., Yamamoto Y. Chlamydia pneumoniae infects and multiplies in lymphocytes in vitro. Infect Immun 2001, 69:7753-7759.
51. Mueller A., Meiser A., McDonagh E.M., Fox J.M., Petit S.J., Xanthou G., Williams T.J., Pease J.E. CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. J Leukoc Biol 2008, 83:875-882.
52. Romagnani P., Maggi L., Mazzinghi B., Cosmi L., Lasagni L., Liotta F., Angeli R., Rotondi M., Filì L., Parronchi P., Serio M., Maggi E., Romagnani S., Annunziato F. CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production. J Allergy Clin Immunol 2005, 116:1372-1379.
53. Sierro F., Biben C., Martinez-Munoz L., Mellado M., Ransohoff R.M., Li M., Woehl B., Leung H., Groom J., Batten M., Harvey R.P., Martínez-A C., Mackay C.R., Mackay F. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA 2007, 104:14759-14764.
54. Luster A.D. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 1998, 338:436-445.
55. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995, 374:546-549.
56. Scheller B., Hennen B., Markwirth T., Schieffer H. Evaluation of the role of Chlamydia pneumoniae in the pathogenesis of atherosclerosis - a review. J Clin Basic Cardiol 2000, 3:155-158.
57. Horwitz M.S., Bradley L.M., Harbertson J., Krahl T., Lee J., Sarvetnick N. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 1998, 4:781-785.
58. Blessing E., Kuo C.C., Lin T.M., Campbell L.A., Bea F., Chesebro B., Rosenfeld M.E. Foam cell formation inhibits growth of Chlamydia pneumoniae but does not attenuate Chlamydia pneumoniae-induced secretion of proinflammatory cytokines. Circulation 2002, 105:1976-1982.
59. Gupta S. Chronic infection in the etiology of atherosclerosis - focus on Chlamydia pneumoniae. Atherosclerosis 1999, 143:1-6.
60. Ngeh J., Anand V., Gupta S. Chlamydia pneumoniae and atherosclerosis - what we know and what we don't. Clin Microbiol Infect 2002, 8:2-13.