메뉴 건너뛰기




Volumn 7, Issue 12, 2011, Pages 1424-1433

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction

Author keywords

Atg13; Autophagy; FIP200; Ulk1; Ulk2

Indexed keywords

AUTOPHAGY PROTEIN 13; AUTOPHAGY PROTEIN 5; COMPLEMENTARY DNA; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE FAMILY INTERACTING PROTEIN 200; UNC 51 LIKE KINASE 1; UNC 51 LIKE KINASE 2; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 82855170846     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.7.12.18027     Document Type: Article
Times cited : (109)

References (39)
  • 1
    • 18244394277 scopus 로고    scopus 로고
    • Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy
    • PMID:15743910
    • Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y. Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 2005; 16:2544-53; PMID:15743910; http://dx.doi.org/10.1091/mbc.E04-08-0669
    • (2005) Mol Biol Cell , vol.16 , pp. 2544-2553
    • Kabeya, Y.1    Kamada, Y.2    Baba, M.3    Takikawa, H.4    Sasaki, M.5    Ohsumi, Y.6
  • 2
    • 0034683568 scopus 로고    scopus 로고
    • Tor-mediated induction of autophagy via an Apg1 protein kinase complex
    • PMID:10995454
    • Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000; 150:1507-13; PMID:10995454; http://dx.doi.org/10.1083/jcb.150.6.1507
    • (2000) J Cell Biol , vol.150 , pp. 1507-1513
    • Kamada, Y.1    Funakoshi, T.2    Shintani, T.3    Nagano, K.4    Ohsumi, M.5    Ohsumi, Y.6
  • 3
    • 34548482499 scopus 로고    scopus 로고
    • siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
    • PMID:17595159
    • Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282:25464-74; PMID:17595159; http://dx.doi.org/10.1074/jbc.M703663200
    • (2007) J Biol Chem , vol.282 , pp. 25464-25474
    • Chan, E.Y.1    Kir, S.2    Tooze, S.A.3
  • 4
    • 0032127805 scopus 로고    scopus 로고
    • Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: CDNA cloning, expression, and chromosomal assignment
    • PMID:9693035
    • Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, et al. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. Genomics 1998; 51:76-85; PMID:9693035; http://dx.doi.org/10.1006/geno.1998.5340
    • (1998) Genomics , vol.51 , pp. 76-85
    • Kuroyanagi, H.1    Yan, J.2    Seki, N.3    Yamanouchi, Y.4    Suzuki, Y.5    Takano, T.6
  • 5
    • 0033377776 scopus 로고    scopus 로고
    • A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons
    • PMID:10624947
    • Tomoda T, Bhatt RS, Kuroyanagi H, Shirasawa T, Hatten ME. A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Neuron 1999; 24:833-46; PMID:10624947; http://dx.doi.org/10.1016/S0896-6273(00)81031-4
    • (1999) Neuron , vol.24 , pp. 833-846
    • Tomoda, T.1    Bhatt, R.S.2    Kuroyanagi, H.3    Shirasawa, T.4    Hatten, M.E.5
  • 6
    • 0033592671 scopus 로고    scopus 로고
    • Mouse ULK2, a novel member of the UNC-51-like protein kinases: Unique features of functional domains
    • PMID:10557072
    • Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, et al. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene 1999; 18:5850-9; PMID:10557072; http://dx.doi.org/10.1038/sj.onc.1202988
    • (1999) Oncogene , vol.18 , pp. 5850-5859
    • Yan, J.1    Kuroyanagi, H.2    Tomemori, T.3    Okazaki, N.4    Asato, K.5    Matsuda, Y.6
  • 7
    • 58149473473 scopus 로고    scopus 로고
    • Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
    • PMID:18936157
    • Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009; 29:157-71; PMID:18936157; http://dx.doi.org/10.1128/MCB.01082-08
    • (2009) Mol Cell Biol , vol.29 , pp. 157-171
    • Chan, E.Y.1    Longatti, A.2    McKnight, N.C.3    Tooze, S.A.4
  • 8
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • PMID:18443221
    • Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181:497-510; PMID:18443221; http://dx.doi.org/10.1083/ jcb.200712064
    • (2008) J Cell Biol , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5    Guan, J.L.6
  • 9
    • 51649124519 scopus 로고    scopus 로고
    • Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    • PMID:18539900
    • Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112:1493-502; PMID:18539900; http://dx.doi.org/10.1182/blood-2008-02-137398
    • (2008) Blood , vol.112 , pp. 1493-1502
    • Kundu, M.1    Lindsten, T.2    Yang, C.Y.3    Wu, J.4    Zhao, F.5    Zhang, J.6
  • 10
    • 33947383050 scopus 로고    scopus 로고
    • ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes
    • PMID:17204848
    • Meijer WH, van der Klei IJ, Veenhuis M, Kiel JA. ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 2007; 3:106-16; PMID:17204848
    • (2007) Autophagy , vol.3 , pp. 106-116
    • Meijer, W.H.1    Van Der Klei, I.J.2    Veenhuis, M.3    Kiel, J.A.4
  • 11
    • 70350449062 scopus 로고    scopus 로고
    • mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex
    • PMID:19690328
    • Chan EY. mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. Sci Signal 2009; 2:pe51; PMID:19690328; http://dx.doi.org/ 10.1126/scisignal.284pe51
    • (2009) Sci Signal , vol.2
    • Chan, E.Y.1
  • 12
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • PMID:19225150
    • Chang YY, Neufeld TP. An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 2009; 20:2004-14; PMID:19225150; http://dx.doi.org/10.1091/mbc.E08-12-1250
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 13
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • PMID:19258318
    • Ganley IG. Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284:12297-305; PMID:19258318; http://dx.doi.org/10.1074/jbc.M900573200
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 14
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • PMID:19211835
    • Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981-91; PMID:19211835; http://dx.doi.org/10.1091/mbc.E08-12-1248
    • (2009) Mol Biol Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3    Kishi, C.4    Takamura, A.5    Miura, Y.6
  • 15
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • PMID:19225151
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003; PMID:19225151; http://dx.doi.org/10.1091/mbc.E08-12-1249
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6
  • 16
    • 0030919092 scopus 로고    scopus 로고
    • Analyses of APG13 gene involved in autophagy in yeast
    • PMID:9224892
    • Funakoshi T, Matsuura A, Noda T, Ohsumi Y. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene 1997; 192:207-13; PMID:9224892; http://dx.doi.org/10.1016/S0378-1119(97)00031-0
    • (1997) Saccharomyces Cerevisiae. Gene , vol.192 , pp. 207-213
    • Funakoshi, T.1    Matsuura, A.2    Noda, T.3    Ohsumi, Y.4
  • 17
    • 77949915406 scopus 로고    scopus 로고
    • AMPK-independent induction of autophagy by cytosolic Ca2+ increase
    • PMID:20114074
    • Grotemeier A, Alers S, Pfisterer SG, Paasch F, Daubrawa M, Dieterle A, et al. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. Cell Signal 2010; 22:914-25; PMID:20114074; http://dx.doi.org/10.1016/j.cellsig.2010. 01.015
    • (2010) Cell Signal , vol.22 , pp. 914-925
    • Grotemeier, A.1    Alers, S.2    Pfisterer, S.G.3    Paasch, F.4    Daubrawa, M.5    Dieterle, A.6
  • 18
    • 77952759763 scopus 로고    scopus 로고
    • Role of inositol trisphosphate receptors in autophagy in DT40 cells
    • PMID:20308071
    • Khan MT, Joseph SK. Role of inositol trisphosphate receptors in autophagy in DT40 cells. J Biol Chem 2010; 285:16912-20; PMID:20308071; http://dx.doi.org/10.1074/jbc.M110.114207
    • (2010) J Biol Chem , vol.285 , pp. 16912-16920
    • Khan, M.T.1    Joseph, S.K.2
  • 19
    • 67549135655 scopus 로고    scopus 로고
    • The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
    • PMID:19325567
    • Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L, et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ 2009; 16:1006-17; PMID:19325567; http://dx.doi.org/10.1038/cdd.2009.34
    • (2009) Cell Death Differ , vol.16 , pp. 1006-1017
    • Vicencio, J.M.1    Ortiz, C.2    Criollo, A.3    Jones, A.W.4    Kepp, O.5    Galluzzi, L.6
  • 20
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • PMID:11060023
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8; PMID:11060023; http://dx.doi.org/10.1093/emboj/19.21.5720
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6
  • 21
    • 33846010776 scopus 로고    scopus 로고
    • Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes
    • PMID:16963441
    • Fass E, Shvets E, Degani I, Hirschberg K, Elazar Z. Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem 2006; 281:36303-16; PMID:16963441; http://dx.doi.org/10.1074/jbc.M607031200
    • (2006) J Biol Chem , vol.281 , pp. 36303-36316
    • Fass, E.1    Shvets, E.2    Degani, I.3    Hirschberg, K.4    Elazar, Z.5
  • 22
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • PMID:17534139
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60; PMID:17534139
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 23
    • 79960020908 scopus 로고    scopus 로고
    • The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
    • PMID: 21460635
    • Lee EJ, Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95; PMID: 21460635; http://dx.doi.org/10.4161/auto.7.7.15450
    • (2011) Autophagy , vol.7 , pp. 689-695
    • Lee, E.J.1    Tournier, C.2
  • 24
    • 64349123107 scopus 로고    scopus 로고
    • Autophagy mediates the mitotic senescence transition
    • PMID:19279323
    • Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, et al. Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23:798-803; PMID:19279323; http://dx.doi.org/10.1101/gad.519709
    • (2009) Genes Dev , vol.23 , pp. 798-803
    • Young, A.R.1    Narita, M.2    Ferreira, M.3    Kirschner, K.4    Sadaie, M.5    Darot, J.F.6
  • 25
    • 50249103834 scopus 로고    scopus 로고
    • The cell biology of autophagy in metazoans: A developing story
    • PMID:18567846
    • Meléndez A, Neufeld TP. The cell biology of autophagy in metazoans: a developing story. Development 2008; 135:2347-60; PMID:18567846; http://dx.doi.org/10.1242/dev.016105
    • (2008) Development , vol.135 , pp. 2347-2360
    • Meléndez, A.1    Neufeld, T.P.2
  • 26
    • 33750366092 scopus 로고    scopus 로고
    • Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
    • PMID: 16940348
    • Young AR, Chan EY, Hu XW, Kochl R, Crawshaw SG, High S, et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci 2006; 119:3888-900; PMID: 16940348; http://dx.doi.org/10.1242/jcs.03172
    • (2006) J Cell Sci , vol.119 , pp. 3888-3900
    • Young, A.R.1    Chan, E.Y.2    Hu, X.W.3    Kochl, R.4    Crawshaw, S.G.5    High, S.6
  • 27
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • PMID:20056399
    • Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132-9; PMID:20056399; http://dx.doi.org/10.1016/j. ceb.2009.12.004
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 28
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • PMID:20562859
    • Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010; 466:68-76; PMID:20562859; http://dx.doi.org/10.1038/nature09204
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 29
    • 77950501014 scopus 로고    scopus 로고
    • mTOR regulation of autophagy
    • PMID:20083114
    • Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010; 584:1287-95; PMID:20083114; http://dx.doi.org/10.1016/j.febslet. 2010.01.017
    • (2010) FEBS Lett , vol.584 , pp. 1287-1295
    • Jung, C.H.1    Ro, S.H.2    Cao, J.3    Otto, N.M.4    Kim, D.H.5
  • 30
    • 75749090429 scopus 로고    scopus 로고
    • Tor directly controls the Atg1 kinase complex to regulate autophagy
    • PMID:19995911
    • Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, et al. Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol 2010; 30:1049-58; PMID:19995911; http://dx.doi.org/10.1128/MCB.01344-09
    • (2010) Mol Cell Biol , vol.30 , pp. 1049-1058
    • Kamada, Y.1    Yoshino, K.2    Kondo, C.3    Kawamata, T.4    Oshiro, N.5    Yonezawa, K.6
  • 31
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • PMID:21205641
    • Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331:456-61; PMID:21205641; http://dx.doi.org/10.1126/science.1196371
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 32
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • PMID:21258367
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41; PMID:21258367; http://dx.doi.org/10.1038/ncb2152
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 33
    • 79960585318 scopus 로고    scopus 로고
    • Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
    • PMID:21690395
    • Cheong H, Lindsten T, Wu J, Lu C, Thompson CB. Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci USA 2011; 108:11121-6; PMID:21690395; http://dx.doi.org/10.1073/pnas.1107969108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11121-11126
    • Cheong, H.1    Lindsten, T.2    Wu, J.3    Lu, C.4    Thompson, C.B.5
  • 34
    • 70350128436 scopus 로고    scopus 로고
    • The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy
    • PMID:19805182
    • Stephan JS, Yeh YY, Ramachandran V, Deminoff SJ, Herman PK. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy. Proc Natl Acad Sci USA 2009; 106:17049-54; PMID:19805182; http://dx.doi.org/10.1073/pnas.0903316106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17049-17054
    • Stephan, J.S.1    Yeh, Y.Y.2    Ramachandran, V.3    Deminoff, S.J.4    Herman, P.K.5
  • 35
    • 79953211917 scopus 로고    scopus 로고
    • Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
    • PMID:21383122
    • Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci USA 2011; 108:4788-93; PMID:21383122; http://dx.doi.org/10.1073/pnas.1100844108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4788-4793
    • Shang, L.1    Chen, S.2    Du, F.3    Li, S.4    Zhao, L.5    Wang, X.6
  • 36
    • 0034046944 scopus 로고    scopus 로고
    • Plat-E: An efficient and stable system for transient packaging of retroviruses
    • PMID:10871756
    • Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 2000; 7:1063-6; PMID:10871756; http://dx.doi.org/10.1038/sj.gt.3301206
    • (2000) Gene Ther , vol.7 , pp. 1063-1066
    • Morita, S.1    Kojima, T.2    Kitamura, T.3
  • 37
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • PMID:19150980
    • Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284:8023-32; PMID:19150980; http://dx.doi.org/10.1074/jbc.M900301200
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5    Gao, Y.6
  • 38
    • 77956720984 scopus 로고    scopus 로고
    • Lysozyme activates Enterococcus faecium to induce necrotic cell death in macrophages
    • PMID:20458518
    • Gröbner S, Fritz E, Schoch F, Schaller M, Berger AC, Bitzer M, et al. Lysozyme activates Enterococcus faecium to induce necrotic cell death in macrophages. Cell Mol Life Sci 2010; 67:3331-44; PMID:20458518; http://dx.doi.org/10.1007/s00018-010-0384-9
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3331-3344
    • Gröbner, S.1    Fritz, E.2    Schoch, F.3    Schaller, M.4    Berger, A.C.5    Bitzer, M.6
  • 39
    • 78751653584 scopus 로고    scopus 로고
    • Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1
    • PMID:21248850
    • Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, et al. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 2011; 469:419-23; PMID:21248850; http://dx.doi.org/10. 1038/nature09674
    • (2011) Nature , vol.469 , pp. 419-423
    • Schroeder, B.O.1    Wu, Z.2    Nuding, S.3    Groscurth, S.4    Marcinowski, M.5    Beisner, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.