-
1
-
-
0036090222
-
Primitive, quiescient, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, et al. Primitive, quiescient, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99(1):319-25.
-
(2002)
Blood
, vol.99
, Issue.1
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
Pearson, C.4
Alcorn, M.J.5
Richmond, L.6
-
2
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M, Hamilton A, Elrick LJ, Baird JW, Allan EK, Jordanides N, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006;107(11):4532-9.
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
Baird, J.W.4
Allan, E.K.5
Jordanides, N.6
-
3
-
-
27644569730
-
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
-
Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell. 2005;8(5):355-68.
-
(2005)
Cancer Cell
, vol.8
, Issue.5
, pp. 355-368
-
-
Neviani, P.1
Santhanam, R.2
Trotta, R.3
Notari, M.4
Blaser, B.W.5
Liu, S.6
-
4
-
-
82855166941
-
PP2A Activating Drugs (PAD): Anti-Leukemic and non-toxic activity of two novel and non-immunosuppressive FTY720 derivatives
-
Walker C, Oaks JJ, Neviani P, Harb JG, Santhanam R, Ma Y, et al. PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic Activity of Two Novel and Non-Immunosuppressive FTY720 Derivatives. Blood. (Suppl.) 2010;116(21):2901.
-
(2901)
Blood. (Suppl.)
, vol.116
, Issue.21
, pp. 2010
-
-
Walker, C.1
Oaks, J.J.2
Neviani, P.3
Harb, J.G.4
Santhanam, R.5
Ma, Y.6
-
5
-
-
77954864204
-
Fingolimod is a potential novel therapy for multiple sclerosis
-
Aktas O, Kury P, Kieseier B, Hartung HP. Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol. 2010;6(7):373-82.
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.7
, pp. 373-3382
-
-
Aktas, O.1
Kury, P.2
Kieseier, B.3
Hartung, H.P.4
-
6
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest. 2007;117(9):2408-21.
-
(2007)
J Clin Invest
, vol.117
, Issue.9
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
Eiring, A.M.4
Notari, M.5
Blaser, B.W.6
-
7
-
-
80051756166
-
BCR-ABL1 Kinase activity but not its expression is dispensable for ph+ quiescent stem cell survival which depends on the PP2AControlled Jak2 activation and is sensitive to FTY720 treatment
-
Neviani P, Harb JG, Oaks JJ, Walker C, Santhanam R, Paisie C, et al. BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2AControlled Jak2 Activation and Is Sensitive to FTY720 Treatment. Blood (Suppl.) 2010;116(21):515.
-
(2010)
Blood
, vol.116
, Issue.21 SUPPL.
, pp. 515
-
-
Neviani, P.1
Harb, J.G.2
Oaks, J.J.3
Walker, C.4
Santhanam, R.5
Paisie, C.6
-
8
-
-
82855162186
-
Pharmacologic restoration of PP2A activity and interference with the SET-PP2A interplay by FTY720 and its non-immunosuppressive derivative as a novel and efficient therapy for Ph-negative Myeloproliferative disorders
-
Oaks JJ, Mukhopadhyay A, Santhanam R, Saddoughi SA, Walker C, Neviani P, et al. Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders. Blood (Suppl.) 2010;116 (21):775.
-
(2010)
Blood
, vol.116
, Issue.21 SUPPL.
, pp. 775
-
-
Oaks, J.J.1
Mukhopadhyay, A.2
Santhanam, R.3
Saddoughi, S.A.4
Walker, C.5
Neviani, P.6
-
9
-
-
77954376747
-
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
-
Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, et al. Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res. 2010;70(13):5438-47.
-
(2010)
Cancer Res
, vol.70
, Issue.13
, pp. 5438-5447
-
-
Roberts, K.G.1
Smith, A.M.2
McDougall, F.3
Carpenter, H.4
Horan, M.5
Neviani, P.6
-
10
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 2011;121(1):396-409.
-
(2011)
J Clin Invest
, vol.121
, Issue.1
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
Cortes, J.4
Deininger, M.W.5
Druker, B.J.6
-
11
-
-
64949147229
-
Jak2 inhibition deactivates Lyn kinase through the SET-PP2ASHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
-
Samanta AK, Chakraborty SN, Wang Y, Kantarjian H, Sun X, Hood J, et al. Jak2 inhibition deactivates Lyn kinase through the SET-PP2ASHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. 2009;28(14):1669-81.
-
(2009)
Oncogene
, vol.28
, Issue.14
, pp. 1669-1681
-
-
Samanta, A.K.1
Chakraborty, S.N.2
Wang, Y.3
Kantarjian, H.4
Sun, X.5
Hood, J.6
-
12
-
-
41949088658
-
BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
-
Copland M, Pellicano F, Richmond L, Allan EK, Hamilton A, Lee FY, et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood. 2008;111(5):2843-53.
-
(2008)
Blood
, vol.111
, Issue.5
, pp. 2843-2853
-
-
Copland, M.1
Pellicano, F.2
Richmond, L.3
Allan, E.K.4
Hamilton, A.5
Lee, F.Y.6
-
13
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest. 2009,119(5): 1109-23.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1109-1123
-
-
Bellodi, C.1
Lidonnici, M.R.2
Hamilton, A.3
Helgason, G.V.4
Soliera, A.R.5
Ronchetti, M.6
-
14
-
-
13044279495
-
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha
-
Salgia R, Quackenbush E, Lin J, Souchkova N, Sattler M, Ewaniuk DS, et al. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999;94(12):4233-46.
-
(1999)
Blood
, vol.94
, Issue.12
, pp. 4233-4246
-
-
Salgia, R.1
Quackenbush, E.2
Lin, J.3
Souchkova, N.4
Sattler, M.5
Ewaniuk, D.S.6
-
15
-
-
38349086394
-
CXCR4 upregulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin L, Tabe Y, Konoplev S, Xu Y, Leysath CE, Lu H, et al. CXCR4 upregulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther. 2008;7(1):48-58.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.1
, pp. 48-58
-
-
Jin, L.1
Tabe, Y.2
Konoplev, S.3
Xu, Y.4
Leysath, C.E.5
Lu, H.6
-
16
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009;458(7239):776-9.
-
(2009)
Nature
, vol.458
, Issue.7239
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
Fereshteh, M.4
Abrahamsson, A.5
Blum, J.6
-
17
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P, et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell. 2008;14(3):238-49.
-
(2008)
Cancer Cell
, vol.14
, Issue.3
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
Zirlik, K.4
Stegert, M.R.5
Manley, P.6
-
18
-
-
71949113371
-
Optimising chronic myeloid leukaemia therapy in the face of resistance to tyrosine kinase inhibitors - A synthesis of clinical and laboratory data
-
Irvine DA, Heaney NB, Holyoake TL. Optimising chronic myeloid leukaemia therapy in the face of resistance to tyrosine kinase inhibitors - A synthesis of clinical and laboratory data. Blood Rev. 2010;24(1):1-9
-
(2010)
Blood Rev
, vol.24
, Issue.1
, pp. 1-9
-
-
Irvine, D.A.1
Heaney, N.B.2
Holyoake, T.L.3
-
19
-
-
77958004008
-
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein
-
Jaras M, Johnels P, Hansen N, Agerstam H, Tsapogas P, Rissler M, et al. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. Proc Natl Acad Sci USA. 2010;107(37):16280-5
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.37
, pp. 16280-16285
-
-
Jaras, M.1
Johnels, P.2
Hansen, N.3
Agerstam, H.4
Tsapogas, P.5
Rissler, M.6
-
20
-
-
70350507997
-
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
-
O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009;16(5):401-12.
-
(2009)
Cancer Cell
, vol.16
, Issue.5
, pp. 401-412
-
-
O'Hare, T.1
Shakespeare, W.C.2
Zhu, X.3
Eide, C.A.4
Rivera, V.M.5
Wang, F.6
-
21
-
-
78650159009
-
Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): Lessons for overcoming kinase inhibitor resistance
-
Zhou T, Commodore L, Huang WS, Wang Y, Thomas M, Keats J, et al. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem Biol Drug Des. 2011;77(1):1-11.
-
(2011)
Chem Biol Drug Des
, vol.77
, Issue.1
, pp. 1-11
-
-
Zhou, T.1
Commodore, L.2
Huang, W.S.3
Wang, Y.4
Thomas, M.5
Keats, J.6
-
22
-
-
79251506692
-
Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia
-
O'Hare T, Deininger MW, Eide CA, Clackson T, Druker BJ. Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia. Clin Cancer Res. 2011;17(2):212-21.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.2
, pp. 212-221
-
-
O'Hare, T.1
Deininger, M.W.2
Eide, C.A.3
Clackson, T.4
Druker, B.J.5
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